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Proguanil
drug data and news
Proguanil drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Proguanil
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| Brand Names/Synonyms |
Chloroguanide; Paludrine; Proguanil |
| Indication |
For the treatment of antimalarial drug prophylaxis |
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Description |
Not Available |
| Pharmacology |
Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil pamoate. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria. However it is slower compared to 4-aminoquinolines. |
| Mechanism Of Action |
Proguanil inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver. |
Proguanil News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Antimetabolites; Antimalarials; ATC:P01BB01 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
1-[amino-(1-methylethylimino)methyl]imino-N-(4-chlorophenyl)-methanediamine |
| Chemical Formula |
C11H16ClN5 |
| Molecular Weight |
253.731 g/mol |
| Smiles String |
CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl |
| Melting Point |
129 °C |
| Water Solubility |
156 mg/L |
| State |
Solid |
| LogP/Hphobicity |
2.558 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
~20 hours . |
| Protein Binding [%] |
~75% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Proguanil.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00188 |
| CAS Registry Number |
500-92-5 |
| KEGG Compound ID |
C07631 |
| PubChem ID |
SID:66102 |
| PharmGKB ID |
PA451124 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2043068
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