Progesterone drug data and news

Progesterone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Progesterone
Brand Names/Synonyms Agolutin; Amen; Bio-Luton; CCRIS 533; Colprosterone; Corlutin; Corlutina; Corluvite; Corporin; Corpus Luteum Hormone; Crinone; Crinone Progesterone Gel; Curretab; Cyclogest; Cyclogesterin; Cycrin; Delalutin; Depo-Provera; Depo-Subq Provera 104; Flavolutan; Fologenon; Gesterol; Gesterol 100; Gesterol 50; Gestiron; Gestone; Gestormone; Gestron; Glanducorpin; Gynlutin; Gynoluton; Gynolutone; HSDB 3389; Hormoflaveine; Hormoluton; Hydroxyprogesterone Caproate; Lingusorbs; Lipo-Lutin; Lucorteum; Lucorteum Sol; Luteal Hormone; Luteine; Luteinique; Luteocrin Normale; Luteodyn; Luteogan; Luteohormone; Luteol; Luteopur; Luteosan; Luteostab; Luteovis; Lutex; Lutidon; Lutin; Lutociclina; Lutocuclin M; Lutocyclin; Lutocyclin M; Lutocylin; Lutocylol; Lutoform; Lutogyl; Lutren; Lutromone; MPA; Medroxyprogesterone Acetate; Membrettes; Methylpregnone; NSC 64377; NSC-9704; Nalutron; PROGESTERONE; Percutacrine; Percutacrine Luteinique; Piaponon; Pranone; Pregnenedione; Prempro/Premphase; Primolut; Prochieve; Progekan; Progestasert; Progesterol; Progesterona [Inn-Spanish]; Progesterone; Progesterone [Ban:Inn:Jan]; Progesterone [Progestins]; Progesteronum; Progesteronum [Inn-Latin]; Progestin; Progestogel; Progestol; Progeston; Progestone; Progestosol; Progestron; Progestronol; Projestaject; Prolets; Prolidon; Prolutin; Proluton; Prolutone; Prometrium; Protormone; Provera; Syngesterone; Syngestrets; Synovex S; Syntolutan; Thiuram E; Thiuranide; Utrogestan
Indication For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used as a female contraceptive.
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Description Not Available
Pharmacology Progesterone is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Progesterone tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.
Mechanism Of Action Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
Progesterone News
(When available)

Abortion Foes Want RU-486 Pill Pulled  16 May 2006
The drug blocks production of the hormone progesterone, which nourishes the fetus, and, when the drug is taken in conjunction with a medication that induces ... - Washington Post,

The biggest boobs  16 May 2006
...estrogen. Taking estrogen-progesterone birth-control pills (classified as "highly carcinogenic" by the World Health Organization). - WorldNetDaily,

Lesbians like men -- with major difference  16 May 2006
In a study of lesbians who smelled a derivative of progesterone found in male sweat and an estrogen-like steroid found in female urine, the female compound ... - United Press International

Self-tanning creams spark rashes, itching  16 May 2006
Although plant-based estrogen and progesterone resemble human hormones, the American College of Obstetricians and Gynecologists says there is no evidence that ... - Charlotte Observer,

Progesterone and Daily Home Uterine Activity Monitoring Prevent ...  May 11, 2006
Charleston, South Carolina, reported the findings of his study, which compared the efficacy of home uterine activity monitoring or progesterone injections for ... - DG News

Columbia Laboratories Added to NASDAQ Biotechnology Index  May 15, 2006
Columbia markets Prochieve(R) 8% (progesterone gel) for progesterone supplementation as part of an Assisted Reproductive Technology treatment for infertile ... - Business Wire (press release),

AMPK activation modulates progesterone secretion in granulosa ...  Apr 27, 2006
In the absence of FSH, AICAR treatment increased progesterone, P450scc and StAR productions in both F3/4 and F1 granulosa cells. ... - Journal of Endocrinology

Seniors recognized for completion of Honors Degrees  May 13, 2006
Sarah Veeder, a psychology major from Avon, NY, completed "Role of Estrogen and Progesterone on Escape Learning in the Rat (Rattus norvegicus)" under the ... - SBU Campus News,

Women's health: contraception  May 13, 2006
As with all pills combining estrogen and progesterone, side effects can include breast tenderness, bleeding, nausea, bloating, headaches, and moodiness. ... - The Journal News.com,

The dangers of hormone replacement  May 12, 2006
Anahad O’Connor says, “A popular cream that eases the symptoms of menopause exposes women to higher levels of the hormone progesterone than has been ... - SheKnows.com,

Redesigning the biological computer -- alternatives to hormone ...  May 12, 2006
...it is natural or not, actually causes the body to slow down the production of its own natural hormones, including melatonin, DHEA, progesterone and human ... - SheKnows.com,

Oxytocin and Maternal Recognition of Pregnancy  May 11, 2006
The CL begins secreting progesterone. The CL secretes progesterone for about two weeks, whether or not mating has occurred and whether ... - TheHorse.com,

Columbia Laboratories Reports First Quarter 2006 Financial Results  May 9, 2006
Banc of America Securities LLC acted as placement agent. -- Enrollment in the Phase III study of Prochieve(R) 8% (progesterone gel) for the prevention of ... - PharmaLive.com (press release),

Long-Term Estrogen Use Linked to Breast Cancer Risk  May 15, 2006
Women who took estrogen for at least 15 years had a higher risk of developing breast cancer with estrogen and progesterone receptors. ... - ACS News Center,

Baby dolphin expected at BC aquarium  May 9, 2006
Blood tests revealing high progesterone levels -- the main hormone of pregnancy -- indicate Hana, an 11-year-old Pacific white-sided dolphin, is pregnant. ... - Guelph Mercury (subscription),

HRT: the fears, the facts  May 3, 2006
...not to take HRT? An increasingly popular alternative is natural progesterone cream, made from wild yam and soy. The late Dr John ... - Saga Health News,

Hormone Use Also Increases Risk of Breast Cancer in Black Women  May 1, 2006
Researchers affiliated with the Black Women’s Health Study have reported that the use estrogen alone or estrogen plus progesterone is associated with an ... - Cancer Consultants (press release),

Long term Estrogen use increases Breast Cancer Risk  May 9, 2006
To avert this risk, HRT for women with a uterus balances estrogen with progesterone. However, adding progesterone to estrogen multiplies ... - Live Punjab,

Insurers Won't Cover $75 Shot That Could Prevent Preterm Births  May 12, 2006
The drug is 17 alphahydroxy progesterone caproate, or 17-P. It is given to women who have already had at least one preterm delivery. ... - KETV.com,

It's hard to detect ovarian cancer  May 14, 2006
The ovaries are paired organs, about the size of an olive, deep in the pelvic area. They produce eggs and the female hormones progesterone and estrogen. ... - Orlando Sentinel,

Reduce sodium, boost calcium to help relieve PMS symptoms  May 9, 2006
The exact cause is unknown. Medical experts believe fluctuating levels of hormones like estrogen and progesterone play a role. According ... - Jackson Clarion Ledger,

NDA submitted for Gestiva for the prevention of preterm delivery  May 5, 2006
Gestiva is a long-acting, naturally occurring form of progesterone. ... Currently, this form of progesterone is prepared solely by compounding pharmacies. ... - RxPG NEWS,

Long-term Estrogen Therapy Linked To Breast Cancer Risk  May 12, 2006
Tumors were classified as positive or negative for estrogen receptor or progesterone receptor based on how they responded to specific hormonal therapies. ... - Medical News Today (press release),

NCSU Researchers Receive $328,500 Grant To Combat Epilepsy  May 9, 2006
Reddy and NCSU researchers have discovered that the hormone progesterone provides some protection against the seizures. Progesterone ... - WRAL.com,

Menopause a natural, not embarrassing, process  May 4, 2006
A: The use of estrogen plus progesterone therapy is associated with small increases in the risk of venous thromboembolic disease, breast cancer, stroke ... - SunHerald.com,

AN INTERVIEW WITH DR. NEAL ROUZIER author of "How To Achieve ...  May 2, 2006
Provera is prescribed to replace progesterone which has recently been shown to protect against cancer. Every woman should be taking progesterone; not Provera. ... - Book Catcher,

Pheromones Point to Sexual Orientation  May 9, 2006
...found the same brain region -- the anterior hypothalamus -- was activated in homosexual men and heterosexual women when exposed to the progesterone derivative 4 ... - Forbes

Lesbians React To Pheromones In A Unique Way  May 9, 2006
...at heterosexual and homosexual men, the researchers found that the Anterior Hypothalamus brain area was activated when exposed to AND (progesterone derivative 4 ... - Medical News Today,

10 Years of Estrogen Alone Increases Breast Cancer Risk  May 8, 2006
...with duration of unopposed estrogen among longer-term users and especially in tumors that were estrogen-receptor positive and progesterone-receptor positive ... - MedPage Today,

Estrogen-Only HRT Safe for 15 Years  May 8, 2006
To avoid this risk, HRT for women with a uterus balances estrogen with progesterone. But adding progesterone to estrogen increases the risk of breast cancer. ... - WebMD

Gay or Straight? The Nose Knows  May 9, 2006
Potential candidates include AND, a progesterone-derived molecule found in men's sweat, and EST, which is related to estrogen and found in pregnant women's ... - Science Now,

Panel's message: Little still known about abortion-pill deaths  May 12, 2006
Mifepristone, sold under the brand name Mifeprex, blocks the action of the hormone progesterone, which is needed to sustain a pregnancy. ... - Oxford Press,

Health Journal: New study emerges on long-term estrogen use  May 9, 2006
The investigators noted that among cancers that have hormone receptors for both estrogen and progesterone, which account for 44 percent of the cases studied ... - Pittsburgh Post Gazette,

Experts find physiological difference in lesbians  May 9, 2006
One steroid was a derivative of the hormone progesterone, called AND, which is detected in human sweat 10 times higher in men than women; the second was an ... - eTaiwan News,

Birth control study alerts older users  May 1, 2006
...hormones? Birth-control pills and menopause drugs both contain hormones that mimic the estrogen and progesterone in a woman's body. ... - Rocky Mountain News,

Lesbian, straight women react differently to sex hormones  May 9, 2006
Researchers tested reactions to the pheromones AND, a progesterone derivative found in men's sweat, and EST, an estrogen-like substance found in the urine of ... - PhysOrg.com,

» This Holy Hand Grenade's a Dud  May 9, 2006
After all, even if Plan B did, in rare cases, prevent implantation, it could do so only by temporarily increasing a woman's level of progesterone -- the same ... - Media girl,

Intrauterine device as satisfactory as surgery for treating heavy ...  May 11, 2006
In the United States, oral drugs for heavy menstrual bleeding include birth control pills, progesterone analogs and nonsteroidal anti-inflammatory drugs. ... - News-Medical.net,

Aquarium getting maternity ward ready for baby dolphin  May 9, 2006
Veterinarian Dr. Dave Huff says blood tests show Hana's progesterone levels are high, suggesting she's pregnant. An ultrasound next ... - CKNW,

Adeza to Present at the Bank of America 2006 Health Care ...  May 11, 2006
May 2006, Adeza announced the submission of a New Drug Application (NDA) with the FDA for Gestiva(TM), a form of a naturally occurring progesterone to prevent ... - Genetic Engineering News,

Breast Cancer Survival Better With Extensive Axillary Disease Than ...  May 1, 2006
Most tumors were estrogen receptor positive (81%) and progesterone receptor positive (60%), while 19% were human epithelial growth factor receptor (HER2 ... - DG News

Health studies' mixed messages  May 9, 2006
...says. HRT studies vary depending on the type of hormone, progesterone or estrogen, and at what age it should begin or end. That ... - The Capital Times,

Treating Breast Cancer: Hormone Therapy  May 11, 2006
Female hormones estrogen and progesterone occur naturally in the body where they control the growth and activity of normal cells. ... - KFDM-TV News,

Integrative way: Breast cancer risk  May 7, 2006
This differed from the data on the estrogen-plus-progesterone combination, which did show an increased risk of breast cancer in women who took it for four ... - Sacramento Bee,

Green Light in Europe for Schering's New Low-Dose Contraceptive  May 10, 2006
...that triggers the positive effects of Yasminelle is called drospirenone, the only synthetic progestogen with a close similarity to progesterone, the female ... - DG News

Gene amplification could guide treatment for high-risk breast ...  May 11, 2006
...breast cancer treatment is being personalized based on the presence of molecular markers, such as HER2, and estrogen and progesterone receptors," said Jorma ... - News-Medical.net,

Dosage Forms CAPSULE; GEL; IMPLANT; LIQUID; SOLUTION
Drug_Category Contraceptives; Progestins; ATC:G03AC06; ATC:G03DA02; ATC:G03DA03; ATC:G03DA04; ATC:L02AB02
Absorption Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.
Interactions -->Interactions for Progesterone:

Drug/Laboratory Test Interactions

The following laboratory results may be altered by the use of estrogen-progestin combination drugs:

  • Increased sulfobromophthalein retention and other hepatic function tests.
  • Coagulation tests: increase in prothrombin factors VII, VIII, IX and X.
  • Metyrapone test.
  • Pregnanediol determination.
  • Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.

Fasting and 2-hour plasma insulin and glucose levels following an oral glucose tolerance test (OGTT) and figrinogen levels were measured in patients receiving PROMETRIUM® Capsules at a dose of 200 mg/day for 12 days per 28 day cycle in combination with conjugated estrogens 0.625 mg/day (n-120). Table 6 summarizes this data. Plasma insulin levels 2 hours post-OGTT were decreased from baseline. The fasting plasma glucose and fasting plasma insulin levels were also decreased from baseline. Glucose levels 2 hours post-OGTT were increased slightly. There was no effect on fibrinogen levels.

For information on changes in lipid profile, see the CLINICAL PHARMACOLOGY, Clinical Studies subsection, Table 5.

Table 6

Mean Changes from Baseline in Insulin and Glucose Levels After 36 Months of Treatment

Parameter
Treatment Group Mean
(Mean % Change)

Conjugated Estrogens 0.625 mg + PROMETRIUM 200mg (cyclical)a

Conjugated Estrogens 0. 625 mg (only)

Placebo

N= 173 to 176b N=170 to 172b N=171

mean

mean % change

mean

mean % change

mean

mean % change

OGTT Insulin
(pmol/L)
Fasting
2 hour
-2.2
-45.2
-6.2
 -14.5
-1.1
 -23.9
-3.2
 -7.9
5.1
 -29.7
14.2
 -9.1
Glucose(mg/dL)
 Fasting
2 hour
-3.0
 3.6
-2.9
 5.2
-2.7
5.0
-2.7
7.8
-1.0
2.1
-0.9
3.9

a There are no significant changes (p<0.05) from conjugated estrogens values
b Number of subjects (N) varies by parameter

Also see CLINICAL PHARMACOLOGY.

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
Chemical Formula C21H30O2
Molecular Weight 314.462 g/mol
Smiles String CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Melting Point 121 °C
Water Solubility 8.81 mg/L
State Solid
LogP/Hphobicity 4.036
Isoelectric Point Not Available
Biotransformation Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones.
Half Life 34.8-55.13 hours
Protein Binding [%] 96%-99%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Progesterone.html
http://www.rxlist.com/cgi/generic/progesterone.htm
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/pro1670.shtml
Drug Type Approved Drug
Accession No APRD00700
CAS Registry Number 57-83-0
KEGG Compound ID C00410
PubChem ID SID:148842
PharmGKB ID PA451123
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2240605

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