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Progabide
drug data and news
Progabide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Progabide
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| Brand Names/Synonyms |
Gabren; Gabrene; Halogabide; Progabida [Inn-Spanish]; Progabide; Progabide [Usan:Ban:Inn]; Progabidum [Inn-Latin] |
| Indication |
Indicated for the treatment of epilepsy. |
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Description |
Not Available |
| Pharmacology |
Progabide, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy. |
| Mechanism Of Action |
Progabide binds to both GABAA and GABAB receptors located on the terminals of primary afferent fibers. Binding to GABAA results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Activation of the GABAB receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters. |
Progabide News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Antiparkinson Agents; Antidyskinetics; Antidepressants; Anticonvulsants; ATC:N03AG05 |
| Absorption |
Well absorbed with a bioavailability of 60% |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
4-[(4-chlorophenyl)-(5-fluoro-2-hydroxy-phenyl)-methylidene]aminobutanamide |
| Chemical Formula |
C17H16ClFN2O2 |
| Molecular Weight |
334.772 g/mol |
| Smiles String |
C1=CC(=CC=C1C(=NCCCC(=O)N)C2=C(C=CC(=C2)F)O)Cl |
| Melting Point |
133-135 °C |
| Water Solubility |
70.9 mg/L |
| State |
Solid |
| LogP/Hphobicity |
3.586 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Hepatic |
| Half Life |
4 hours |
| Protein Binding [%] |
95% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00072 |
| CAS Registry Number |
62666-20-0 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:184378 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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