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Proflavine
drug data and news
Proflavine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Proflavine
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| Brand Names/Synonyms |
Isoflav Base; Pro-Gen; Proflavin; Proflavine; Profoliol; Profoliol-B; Proformiphen; Profundol; Profura; Progarmed; Progesic |
| Indication |
For the treatment of superficial injuries |
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Description |
Not Available |
| Pharmacology |
Proflavine is an acriflavine derivative which is a disinfectant bacteriostatic against many gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds. |
| Mechanism Of Action |
Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction. |
Proflavine News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Anti-Infectives, local; ATC:D08AA02 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Not Available |
| Chemical IUPAC Name |
acridine-3,6-diamine |
| Chemical Formula |
C13H11N3 |
| Molecular Weight |
209.247 g/mol |
| Smiles String |
C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N |
| Melting Point |
285 °C |
| Water Solubility |
5E+005 mg/L |
| State |
Solid |
| LogP/Hphobicity |
2.007 |
| Isoelectric Point |
8.06 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00535 |
| CAS Registry Number |
92-62-6 |
| KEGG Compound ID |
C11181 |
| PubChem ID |
SID:13362 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
http://www.hc-sc.gc.ca/drug2/dc/product/p5323.html
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