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Procyclidine
drug data and news
Procyclidine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Procyclidine
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| Brand Names/Synonyms |
Arpicolin; CHEMBANK1057; Elorine; Kemadrin; Kemadrine; Lergine; Metanin; Osnervan; Prociclidina [Inn-Spanish]; Procidlidina; Procyclid; Procyclidine; Procyclidinum [Inn-Latin]; Procyklidin; Prosyklidin; Spamol; Triciclidina; Triciloid; Tricoloid; Tricyclamol; Vagosin |
| Indication |
For the treatment of Parkinson's Disease (especially drug induced) |
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Description |
Not Available |
| Pharmacology |
Procyclidine has an atropine-like action. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents. |
| Mechanism Of Action |
The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. |
Procyclidine News
(When available) |
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| Dosage Forms |
TABLET; ELIXIR |
| Drug_Category |
Antiparkinson Agents; Antidyskinetics; Antiparkinson Agents; Muscarinic Antagonists; ATC:N04AA04 |
| Absorption |
Not Available |
| Interactions |
Drug Interactions:
Procyclidine can interact with the follwing drugs:
amantadine or rimantadine, narcotic analgesics, amitriptyline (Elavil, Endep), doxepin (Sinequan), or
clomipramine (Anafranil), quinidine (Quinora, Quinaglute, Quinidex, Cardioquin), some antiarrhythmics,
antihistamines (diphenhydramine, chlorpheniramine, triprolidine, brompheniramine, clemastine, etc),
Atenolol, Cholinergic agents (tacrine and donepezil), Digoxin, Levodopa, phenothiazines, chlorpromazine
(Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine
(Mellaril), promazine (Sparine), trifluoperazine, and haloperidol.
Drugs other than listed here may also have interactions with Procyclidine.
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| Toxicity |
LD50=60 mg/kg (IV in mice) |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol |
| Chemical Formula |
C19H29NO |
| Molecular Weight |
287.44 g/mol |
| Smiles String |
C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O |
| Melting Point |
86 °C |
| Water Solubility |
Moderately soluble in water, ~ 30 mg/ml |
| State |
Solid |
| LogP/Hphobicity |
4.37 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
~100%-albumin |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Procyclidine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00383 |
| CAS Registry Number |
77-37-2 |
| KEGG Compound ID |
C07378 |
| PubChem ID |
SID:9582 |
| PharmGKB ID |
PA451117 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
587354
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