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Prochlorperazine
drug data and news
Prochlorperazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Prochlorperazine | ||
| Brand Names/Synonyms | 6140 R.P.; 6140 RP; Bayer a 173; Buccastem; COMPAZINE; Capazine; Chlormeprazine; Chlorperazine; Combid; Compazine; Compro; Emelent; Emetiral; Eskatrol; Kronocin; Meterazin; Meterazin Maleate; Meterazine; Nipodal; Novamin; Pasotomin; Prochloroperazine; Prochlorpemazine; Prochlorperazin; Prochlorperazine; Prochlorperazine Edisylate; Prochlorperazine Maleate; Prochlorpromazine; Procloperazine; Proclorperazine; RP-6140; SKF 4657; Stemetil; Tementil; Temetid; Vertigon | ||
| Indication | For control of severe nausea and vomiting, also used in management of the manifestations of psychotic disorders | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Prochlorperazine, a piperazine phenothiazine related to high-potency neuroleptics such as perphenazine, is used as an antiemetic and antipsychotic agent in the management of nausea and vomiting. It shares many of the actions and adverse effects of the antipsychotics. | ||
| Mechanism Of Action | Prochlorperazine blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. The antiemetic effects of prochlorperazine can be attributed to dopamine blockade in the chemoreceptor trigger zone. Prochlorperazine also blocks anticholinergic and alpha-adrenergic receptors, the blockade of alpha(1)-adrenergic receptors resulting in sedation, muscle relaxation, and hypotension. | ||
| Prochlorperazine News (When available) |
Alexza Reports First Quarter Financial Results and Updates Its ... May 15, 2006 | ||
| Dosage Forms | Tablets, Spansule, capsules, Vials, Suppositories, Syrup | ||
| Drug_Category | Antipsychotics; Antiemetics; Phenothiazines; ATC:N05AB04 | ||
| Absorption | rapidly absorbed following oral administration | ||
| Interactions |
Interactions for Prochlorperazine: Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. Antihypertensive effects of guanethidine and related compounds may be counteracted when phenothiazines are used concomitantly. Concomitant administration of propranolol with phenothiazines results in increased plasma levels of both drugs. . | ||
| Toxicity | Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine | ||
| Chemical Formula | C20H24ClN3S | ||
| Molecular Weight | 373.943 g/mol | ||
| Smiles String | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl | ||
| Melting Point | 228°C | ||
| Water Solubility | Very slightly soluable | ||
| State | Solid | ||
| LogP/Hphobicity | 4.99 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 6 to 8 hours | ||
| Protein Binding [%] | 91-99% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Prochlorperazine.html http://www.rxlist.com/cgi/generic/prochlr.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00624 | ||
| CAS Registry Number | 58-38-8 | ||
| KEGG Compound ID | C07403 | ||
| PubChem ID | SID:312699 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 753637 |
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