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Procaine
drug data and news
Procaine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Procaine | ||
| Brand Names/Synonyms | Allocaine; Chloroprocaine Hcl; Diethylaminoethyl P-Aminobenzoate; Duracaine; Duracillin A.S.; Gerovital; Gerovital H-3; Jenacain; Jenacaine; Neocaine; Nesacaine; Nissocaine; Norocaine; Novocain; Novocaine; P-Aminobenzoyldiethylaminoethanol; Penicillin G Procaine; Pfizerpen-As; Procain; Procaine; Procaine Hcl; Procaine Hydrochloride; Procaine, Base; Scurocaine; Spinocaine; Vitamin H3 | ||
| Indication | Used as a local anesthetic primarily in oral surgery | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine. | ||
| Mechanism Of Action | Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex. | ||
| Procaine News (When available) |
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| Dosage Forms | LIQUID | ||
| Drug_Category | Anesthetics; Local Anesthetics; ATC:C05AD05; ATC:D04AB03; ATC:J01CE09; ATC:N01BA02; ATC:N01BA04; ATC:S01HA02; ATC:S01HA05 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-diethylaminoethyl4-aminobenzoate | ||
| Chemical Formula | C13H20N2O2 | ||
| Molecular Weight | 236.31 g/mol | ||
| Smiles String | CCN(CC)CCOC(=O)C1=CC=C(C=C1)N | ||
| Melting Point | 61 °C | ||
| Water Solubility | 9450 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.845 | ||
| Isoelectric Point | 8.05 | ||
| Biotransformation | Hydrolysis by plasma esterases to PABA | ||
| Half Life | 7.7 minutes | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Procaine.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00650 | ||
| CAS Registry Number | 59-46-1 | ||
| KEGG Compound ID | C07375 | ||
| PubChem ID | SID:9579 | ||
| PharmGKB ID | PA451110 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2241979 |
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