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Primidone
drug data and news
Primidone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Primidone | ||
| Brand Names/Synonyms | Apo-Primidone; Cyral; Desoxyphenobarbitone; Hexadiona; Hexamidine; Lepimidin; Lepsiral; Liskantin; Majsolin; Medi-Pets; Midone; Milepsin; Misodine; Misolyne; Mizodin; Mizolin; Myidone; Mylepsin; Mylepsinum; Mysedon; Mysoline; NCI-C56360; Neurosyn; Pms Primidone; Prilepsin; Primacione; Primaclone; Primacone; Primakton; Primidon; Primidone; Primidone Methanol Solution; Primoline; Prysoline; Pyrimidone "Medi-Pets"; Pyrimidone &Quot;Medi-Pets&Quot;; Pyrimidone Medi-Pets; Resimatil; Roe 101; Sertan | ||
| Indication | For the treatment of epilepsy | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Primidone is a barbiturate with anticonvulsant properties. Primidone, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Primidone raises electro- or chemoshock seizure thresholds or alters seizure patterns in experimental animals. Primidone per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). In addition to its anticonvulsant activity, Primidone potentiates that of phenobarbital in experimental animals. | ||
| Mechanism Of Action | Primidone is a GABA receptor agonist. The mechanism of Primidone's antiepileptic action is not known. | ||
| Primidone News (When available) |
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| Dosage Forms | TABLET; CHEWABLE TABLETS; Oral suspension | ||
| Drug_Category | Anticonvulsants; Barbiturates; ATC:N03AA03 | ||
| Absorption | 90 to 100% | ||
| Interactions |
Interactions for Primidone: No information provided. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione | ||
| Chemical Formula | C12H14N2O2 | ||
| Molecular Weight | 218.252 g/mol | ||
| Smiles String | CCC1(C(=O)NCNC1=O)C2=CC=CC=C2 | ||
| Melting Point | 281.5 °C | ||
| Water Solubility | 500 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.713 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 3-23 hours | ||
| Protein Binding [%] | 70% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Primidone.html http://www.rxlist.com/cgi/generic2/primid.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00549 | ||
| CAS Registry Number | 125-33-7 | ||
| KEGG Compound ID | C07371 | ||
| PubChem ID | SID:173378 | ||
| PharmGKB ID | PA451105 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 396761 |
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