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Prilocaine
drug data and news
Prilocaine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Prilocaine
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| Brand Names/Synonyms |
Astra 1512; Astra 1515; Citanest; Citanest Forte; Citanest Plain; Emla; L 67; Prilocaine; Propitocaine |
| Indication |
Used as a local anaesthetic |
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Description |
Not Available |
| Pharmacology |
Prilocaine, a hydantoin anticonvulsant, is used alone or with phenobarbital or other anticonvulsants to manage tonic-clonic seizures, psychomotor seizures, neuropathic pain syndromes including diabetic neuropathy, digitalis-induced cardiac arrhythmias, and cardiac arrhythmias associated with QT-interval prolongation. |
| Mechanism Of Action |
Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. |
Prilocaine News
(When available) |
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| Dosage Forms |
SOLUTION |
| Drug_Category |
Anesthetics; Local Anesthetics; ATC:N01BB04 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
N-(2-methylphenyl)-2-propylamino-propanamide |
| Chemical Formula |
C13H20N2O |
| Molecular Weight |
220.311 g/mol |
| Smiles String |
CCCNC(C)C(=O)NC1=CC=CC=C1C |
| Melting Point |
37-38 °C |
| Water Solubility |
541 mg/L |
| State |
Solid |
| LogP/Hphobicity |
2.423 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
98% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Prilocaine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00180 |
| CAS Registry Number |
721-50-6 |
| KEGG Compound ID |
C07531 |
| PubChem ID |
SID:9734 |
| PharmGKB ID |
PA451101 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
519235
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