Prednisone drug data and news

Prednisone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Prednisone
Brand Names/Synonyms &Laquo;Delta&Raquo; E.; &Laquo;Delta&Raquo;-Cortelan; &Laquo;Delta&Raquo;-Cortisone; &Laquo;Delta&Raquo;-Cortone; &Laquo;Delta&Raquo;-Dome; &Laquo;Delta&Raquo;-E; .Delta. E; .Delta.-Cortelan; .Delta.-Cortisone; .Delta.-Cortone; .Delta.-E; .Delta.Sone; Adasone; Ancortone; Apo-Prednisone; Betapar; Bicortone; CCRIS 2646; Cartancyl; Colisone; Cortan; Cortancyl; Cortidelt; Cotone; DRG-0227; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dehydrocortisone; Dekortin; Delcortin; Dellacort; Dellacort A; Delta Cortelan; Delta E; Delta E.; Delta-Cortelan; Delta-Cortisone; Delta-Dome; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltison; Deltisona; Deltisone; Deltra; Di-Adreson; Diadreson; Econosone; Encorton; Encortone; Enkorton; Fernisone; Fiasone; HSDB 3168; Hostacortin; In-Sone; Incocortyl; Juvason; Liquid Pred; Lisacort; Me-Korti; Metacortandracin; Meticorten; Nisona; Nizon; Novoprednisone; Nurison; Orasone; Origen Prednisone; PRD; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicen-M; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisona [Inn-Spanish]; Prednisone; Prednisone Intensol; Prednisone [Ban:Inn]; Prednisonum [Inn-Latin]; Prednitone; Prednizon; Prednovister; Presone; Pronison; Rectodelt; Reserpine; Reserpine Base; Reserpine Puriss; Retrocortine; Servisone; Sk-Prednisone; Sone; Sterapred; Supercortil; U 6020; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid; Zenadrid [Veterinary]
Indication For the treatment of primary or secondary adrenocortical insufficiency. Also used in the treatment of several other conditions, including rheumatic disorders, collagen diseases, and dermatological diseases.
Sponsored links
Description Not Available
Pharmacology Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has very little mineralocorticoid activity.
Mechanism Of Action Prednisone is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Prednisone News
(When available)

Self-tanning creams spark rashes, itching  16 May 2006
Q. I am on daily low-dose prednisone. Because this drug can weaken bones, I am supposed to take Actonel to prevent osteoporosis. ... - Charlotte Observer,

People's Pharmacy: Alternative arthritis treatments  May 13, 2006
She prescribed prednisone, which helped the rash for a while and even eased the arthritis pain. ... Now my doctor wants me to take more prednisone. ... - Bryan College Station Eagle,

Cell Genesys Receives Fast Track Status for GVAX(R) Immunotherapy ...  May 10, 2006
...chemotherapy naïve, asymptomatic patients without cancer-related pain and will compare GVAX cancer immunotherapy to Taxotere chemotherapy plus prednisone. ... - Yahoo! News (press release)

FDA Grants Fast Track Designation For Cell Genesys' GVAX ...  May 10, 2006
Each Phase 3 trial is expected to enroll 600 patients and is designed to demonstrate a survival benefit compared to Taxotere plus prednisone. ... - Trading Markets,

Pets deal with allergy season also  May 7, 2006
Antihistamines and various forms of cortisone such as "Prednisone" are used individually or in combination to manage allergic itching in pets. ... - Tri-Valley Herald,

Cell Genesys up on FDA GVAX fast track  May 10, 2006
...cancer treatment before. The trial will compare GVAX to Sanofi-Aventis SA's Taxotere chemotherapy plus the steroid prednisone. In the ... - BusinessWeek

Cell Genesys Cancer Drug Gets FDA Fast-Track Status  May 10, 2006
The first trial will compare GVAX to Taxotere chemotherapy plus prednisone. The second trial will compare GVAX plus Taxotere chemotherapy ... - Wall Street Journal,

Bisphosphonate-Associated Mandibular Osteonecrosis  May 10, 2006
SUMMARY: A 66-year-old man with multiple myeloma treated with zoledronic acid, melphalan, and prednisone after a tooth extraction developed severe ... - AJNR (subscription),

Allergy sufferers beware  May 8, 2006
Or, you can use medication such as antihistamines, nose spray or Singular. If you are totally miserable, Prednisone, a steroid, can help. ... - Janesville Gazette,

Help for Eye Disease  Apr 16, 2006
...scleritis. Johns Hopkins University ophthalmologist Jennifer Thorne, MD, says the steroid prednisone is a common treatment. "It's ... - ABC30.com,

Rituxan® Improves Outcomes of Young Patients with Good-Prognosis ...  May 1, 2006
Trial (MInT) Group have reported that Rituxan (rituximab) added to six cycles of CHOP-21 (cyclophosphamide, doxorubicin, oncovin, and prednisone) or other CHOP ... - Cancer Consultants (press release),

Teen deserves a gold medal for guts, too  May 12, 2006
...of today's event, Joanne Nichols confesses the lengths to which her son will go to play hockey: "Sometimes when Andrew has to take Prednisone and Vincristine ... - Winnipeg Free Press (subscription),

Exposure to tear gas  May 9, 2006
...on medications that weaken the immune system, (ie: chemotherapy, Lupus, HIV, radiation, or long-term corticosteroids such as prednisone) risk exacerbation of ... - The Daily Star,

Christopher's first birthday  May 10, 2006
Poof! Gone! So, I went to the doctor on Friday and was prescribed six days of Prednisone. It's starting to help, but is taking way longer than I'd prefer. ... - WDBJ7.com,

Steroid Treatment for Cardiac Function in Duchenne Muscular ...  May 1, 2006
Of the 48 treated patients, 29 received prednisone, and 19 received deflazacort (a derivative of prednisolone reported to cause less weight gain). ... - AAP Grand Rounds (subscription),

Bandages of Honor  May 10, 2006
It took more than a week of prednisone and Benadryl to get it under control and return me to planting out the peas, with few days to enjoy that brief, innocent ... - Washington Post,

High-Dose Corticosteroids Tied to Increased Risk of Atrial ...  May 9, 2006
However, only high-dose corticosteroid use -- defined as oral or parenteral steroid at a daily dose of 7.5 mg/day or more of prednisone equivalents -- was ... - Medscape (subscription)

GPC Biotech's SPARC study gets DMB OK  Apr 26, 2006
Germany's GPC Biotech says that the independent data monitoring board for the Phase III Satraplatin and Prednisone Against Refractory Cancer study (SPARC), has ... - Therapeutics Daily (subscription) (press release),

Cell Genesys Reports First Quarter 2006 Financial Results  May 8, 2006
...previously published median survival of 18.9 months for metastatic HRPC patients treated with Taxotere(R) (docetaxel) chemotherapy plus prednisone, the current ... - International News Service,

High-Dose Steroids Linked to Risk of Atrial Fibrillation  May 8, 2006
A daily dose of at least 7.5 mg of prednisone equivalents was associated with a sixfold increase in risk of new onset atrial fibrillation, Cornelis S. van der ... - MedPage Today,

What does mentally ill mean anyway? Can we be part of the cure?  May 4, 2006
She was extremely sick and after the 5th trip to the hospital the Dr decided to give her a drug known as prednisone to help her breathe,. ... - ProgressiveU.org,

Asthma should not rule out activity  May 4, 2006
Parents just have to manage their condition.'. "A doctor would probably write a prescription for Prednisone to be used in extreme emergencies," she says. ... - Toronto Star,

Balloon Therapy  May 4, 2006
...life. Despite four courses of antibiotics and a course of prednisone, three months later her sinuses were still inflamed. Stumped ... - Forbes

Spectrum Pharmaceuticals Reports First Quarter 2006 Financial ...  May 8, 2006
The independent Data Monitoring Board (DMB) for the SPARC (Satraplatin and Prednisone Against Refractory Cancer) Phase 3 registrational trial in second-line ... - Yahoo! News (press release)

Getting the most from calcium  Apr 30, 2006
In addition to foods, says nutritionist Tamara Swett, other factors decrease calcium absorption, like prednisone and other medications and loss of estrogen. ... - Seattle Times,

Biogen Idec Reports First Quarter 2006 Results  Apr 26, 2006
...with low-grade or follicular, CD20-positive, B-cell non-Hodgkin's lymphoma in combination with CVP (cyclophosphamide, vincristine and prednisone) or CHOP ... - Genetic Engineering News,

Independent Data Monitoring Board Recommends to Continue ...  Apr 25, 2006
GPC; TecDAX index; Nasdaq: GPCB) today announced that the independent Data Monitoring Board (DMB) for the SPARC (Satraplatin and Prednisone Against Refractory ... - International News Service,

INDEPENDENT DATA MONITORING BOARD RECOMMENDS THAT SATRAPLATIN ...  Apr 25, 2006
...the independent Data Monitoring Board (DMB) for GPC Biotech's satraplatin Phase 3 registrational trial SPARC (Satraplatin and Prednisone Against Refractory ... - ITNews,

Michelle Rodriguez Agrees to Jail Time  Apr 25, 2006
...allergies. She said she's allergic to dust and cockroach feces. "Prednisone and cortisone steroid -- that was hardcore," she said. "I ... - KHNL-TV/KHBC/KOGG,

Sweeney unveils airport funding  Apr 21, 2006
Sweeney is recovering from vasculitis, or swollen blood vessels, in his brain, for which he is taking Prednisone, a steroid. "I'm feeling good. ... - Albany Times Union,

Case 13-2006 — A 50-Year-Old Man with a Painful Bone Mass and ...  Apr 26, 2006
A 10-day course of prednisone and a trial of rofecoxib resulted in no improvement over a period of 6 weeks. Two and a . . . [Full Text of this Article]. - New England Journal of Medicine (subscription),

Kitchen Chief  Apr 17, 2006
..."She says there's a need there.". Schultz, who takes prednisone for her lupus, soldiers on in pain from her arthritis. "Sometimes I hurt really bad," she said. ... - Press-Enterprise (subscription),

Dose-Dense R-CHOP-14 Can Be Safely Administered to NHL Patients ...  Apr 25, 2006
...patients with diffuse large B-cell lymphoma (DLBCL) receiving dose-dense R-CHOP-14 (rituximab-cyclophosphamide, doxorubicin, oncovin and prednisone) every 14 ... - Cancer Consultants (press release),

What Would You Do?  Apr 20, 2006
But after college, when a doctor prescribed prednisone, a steroid/anti-inflammatory, to relieve gout pain, I took the medication without questioning the doctor ... - ESPN

Dose-Dense Therapy for NHL Safely Administered with Support of ...  Apr 18, 2006
...for the safe administration of the dose-dense treatment regimen R-CHOP-14 (rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone, given every 14 ... - Cancer Consultants (press release),

Independent Data Monitoring Board Recommends that GPC Biotech ...  Apr 25, 2006
...that the independent Data Monitoring Board (DMB) for the satraplatin Phase 3 registrational trial SPARC (Satraplatin and Prednisone Against Refractory Cancer ... - Yahoo! News (press release)

Dosage Forms Tablets, Ointments, creams, oral liquids
Drug_Category Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A07EA03; ATC:H02AB07; ATC:H02AB15
Absorption readily absorbed from the gastro-intestinal tract
Interactions Interactions for Prednisone:

The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.

Toxicity LD50=mg/kg (orally in rat)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
Chemical Formula C21H26O5
Molecular Weight 358.428 g/mol
Smiles String CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
Melting Point 233 - 235 °C
Water Solubility 312 mg/L
State Solid
LogP/Hphobicity 1.471
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 2 to 3 hours
Protein Binding [%] extensively bound to plasma proteins
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Prednisone.html
http://www.rxlist.com/cgi/generic/pred.htm
Drug Type Approved Drug
Accession No APRD00340
CAS Registry Number 53-03-2
KEGG Compound ID C07370
PubChem ID SID:148670
PharmGKB ID PA451100
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 868426

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