Pravastatin drug data and news

Pravastatin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Pravastatin
Brand Names/Synonyms CCRIS 7557; Compactin; Elisor; Lipostat; Lovastatin; Mevalotin; Mevastatin; Mevinolin; Oliprevin; Pravachol; Pravaselect; Pravastatin; Pravastatin Sodium; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]; Selectin; Selipran; Vasten
Indication For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.
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Description Not Available
Pharmacology Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation.
Mechanism Of Action Like lovastatin and simvastatin, pravastatin inhibits hydroxymethylglutaryl-CoA (HMG-CoA) reductase. As HMG-CoA is necessary for the intracellular synthesis of cholesterol, its inhibition results in increased clearance of circulating LDL. Pravastatin also inhibits hepatic synthesis of VLDL, the precursor for LDL, reducing circulating cholesterol and LDL cholesterol.
Pravastatin News
(When available)

Acetaminophen May Help Pain but Not Heart after Heart Attack  16 May 2006
...many older people. The first, Pravastatin, is a generic version of the cholesterol-lowering drug Pravachol. The second, Cilostazol ... - SeniorJournal.com,

Women on cholesterol fighters don't raise breast cancer risk  16 May 2006
...hydrophilic statins, which are water-soluble. They include drugs such as Pravastatin and Lipitor. Overall, women in the study taking ... - Newark Star Ledger,

Clinical trial backs Crestor over rival statins  16 May 2006
...products are likely to come under pressure in the latter half of this year with both Zocor and Bristol-Myers Squibb's Pravachol (pravastatin) losing patent ... - Pharma Times (subscription),

FDA Approves First Generic Pravastatin  May 9, 2006
The FDA recently approved the first generic version of Bristol-Myers Squibb's Pravachol (Pravastatin Sodium Tablets), an important step in the agency's effort ... - Pharmaceutical Processing,

The pravastatin chance  Apr 25, 2006
The latest is about pravastatin, a cholesterol reducing blockbuster medication, the patents for which was held by Bristol Myers Squibb till April 20, 2006. ... - Daily News & Analysis,

Teva wins exclusive marketing rights to Pravastatin  Apr 20, 2006
...challenge to Teva's 180 days of marketing exclusivity for the first generic version of Bristol-Myers Squibb's (NYSE:BMY) Pravachol (pravastatin sodium) tablets ... - Globes,

(PRN) - Watson Pharmaceuticals Launches Pravastatin Tablets ... ...  Apr 25, 2006
...(PRN) - 12th Annual Unity Walk is a Catalyst for Hope and Promise for the Parkinson's Disease Community ... [+. PRN) - Intellistrand ... - Bolsamania.com,

FDA Approves First Generic Pravastatin, USA  Apr 27, 2006
The Food and Drug Administration today approved the first generic version of Bristol-Myers Squibb's Pravachol (Pravastatin Sodium Tablets), an important step ... - Medical News Today (press release),

Watson Pharmaceuticals Launches Pravastatin Tablets  Apr 25, 2006
...that under a distribution agreement with Bristol-Myers Squibb Company (NYSE: BMY - News), the Company has initiated shipments of pravastatin sodium tablets in ... - Yahoo! News (press release)

Watson Pharmaceuticals Ships Pravastatin Tablets  Apr 25, 2006
...(WPI) began shipping pravastatin sodium tablets in 10-, 20- and 40-milligram dosages under a distribution agreement with Bristol-Myers Squibb Co. (BMY). ... - Therapeutics Daily (subscription) (press release),

FDA Approves First Generic Pravastatin  Apr 25, 2006
Md., April 24, 2006--The Food and Drug Administration today approved the first generic version of Bristol-Myers Squibb's Pravachol (Pravastatin Sodium Tablets ... - PharmaLive.com (press release),

Watson Pharmaceuticals Launches Pravastatin Tablets  Apr 25, 2006
...announced today that under a distribution agreement with Bristol-Myers Squibb Company , the Company has initiated shipments of pravastatin sodium tablets in ... - PharmaLive.com (press release),

Starting Statins Early During Acute Coronary Syndrome May Improve ...  May 15, 2006
...presentation with ACS. Three of the trials used atorvastatin, 1 used simvastatin, 4 used pravastatin and 1 used fluvastatin. In the ... - DG News

Clinical Data Announces Research Collaboration Agreement with Duke ...  May 15, 2006
...previously announced, the Clinical Data STRENGTH studies involved evaluating the response of 679 patients to atorvastatin, pravastatin, simvastatin, lovastatin ... - GenomicsProteomics.com (press release),

Generic Pravachol Approved  May 10, 2006
The Food and Drug Administration has approved a generic version of the cholesterol-lowering drug pravastatin (brand name Pravachol). ... - Diabetes Self Management

Ranbaxy alone gets exclusivity for 80 mg?  Apr 19, 2006
According to CNBC-TV18, the US FDA ruling may help Teva get exclusivity for Pravastatin from April 20. ... Pravastatin is also one of them. ... - Moneycontrol.com,

Teva Pharma Reveals District Court Of Columbia Vacated Stay Of ...  Apr 20, 2006
...stay of approval of its Abbreviated New Drug Application/ANDA to market its generic version of Bristol-Myers Squibb's Pravachol or Pravastatin Sodium Tablets ... - Trading Markets,

FDA Announces the Approval of First Version of Generic Pravachol  Apr 25, 2006
The Food and Drug Administration (FDA) has announced the approval of the first generic version of Bristol-Myers Squibb’s Pravachol (Pravastatin Sodium Tablets ... - Newsinferno.com,

FDA Approves First Generic Version Of Pravachol  Apr 24, 2006
DC (AHN) - The Food and Drug Administration approves on Monday the first generic version of Bristol-Myers Squibb's Pravachol or Pravastatin Sodium Tablets. ... - All Headline News

Teva receives first FDA approval for generic Pravachol  Apr 25, 2006
...for the company's abbreviated new drug application (ANDA) to market its generic version of Bristol-Myers Squibb's Pravachol (Pravastatin Sodium) Tablets, 10 mg ... - Globes,

Pfizer's 2006 Lipitor sales target seen as difficult  May 8, 2006
...generically. And in April the patent for Bristol-Myers Squibb Co.'s (BMY) Pravachol expired, clearing the way for generic pravastatin. ... - MarketWatch

FDA Approves Generic Version Of Cholesterol Drug  Apr 25, 2006
Pravachol (Pravastatin Sodium Tablets) is indicated for the treatment of individuals with high cholesterol levels or who are at increased risk for ... - Consumer Affairs

Early Statins Disappointing After Acute Coronary Syndrome  May 2, 2006
Six of the studies compared Pravachol (pravastatin) to placebo or usual care; three compared Lipitor (atorvastatin) to placebo or usual care; two compared ... - MedPage Today,

Your health questions answered  May 9, 2006
A. The great majority of people who take statins (simvastatin, pravastatin, atorvastatin, and others) experience no side effects at all. ... - Independent,

2006 Will Bring a Significant Change to the Statin Market as ...  Apr 27, 2006
This report reviews key patent expiries, including the imminent US expiries of pravastatin (Bristol-Myers Squibb's Pravachol) and simvastatin (Merck & Co.'s ... - Genetic Engineering News,

Watson follows Teva with generic Pravachol  Apr 26, 2006
The launch of the 'authorised generic' comes immediately after Teva Pharmaceutical Industries entered the market for generic Pravachol (pravastatin) in the USA ... - Pharma Times (subscription),

Addition Of A Bile Acid Sequestrant (WelChol, Colesevelam HCl) To ...  Apr 19, 2006
...colesevelam hydrochloride) to stable statin therapy (ie Zocor(R) (simvastatin), Lipitor(R) (atorvastatin calcium) or Pravachol(R) (pravastatin sodium)) further ... - Medical News Today (press release),

District Court Denies Apotex's Request to Block Teva's ...  Apr 20, 2006
...challenge to Teva's 180 days of marketing exclusivity for the first generic version of Bristol-Myers Squibb's Pravachol(R) (pravastatin sodium) Tablets in the ... - PharmaLive.com (press release),

First Data to Show Addition of a Bile Acid Sequestrant (WelChol ...  Apr 18, 2006
...colesevelam hydrochloride) to stable statin therapy (ie Zocor® (simvastatin), Lipitor® (atorvastatin calcium) or Pravachol® (pravastatin sodium)) further ... - Market Wire (press release)

FDA Oks Teva's generic version of pravachol  Apr 24, 2006
...(TEVA), based in Kfar Sava, Israel, to sell the drug, known generically as pravastatin, in 10, 20 and 40 milligram strengths. Apotex Inc. ... - MarketWatch

Generic Pharma Firms Stand To Benefit From Patent Expirations ...  May 8, 2006
Brokerage Prudential Financial expects that Teva's earnings would be pushed up by the launch of generic pravastatin in April, followed by Zoloft and Proscar in ... - Trading Markets,

Teva Receives First FDA Approval for Generic Pravachol(R) ...  Apr 25, 2006
...for the Company's Abbreviated New Drug Application (ANDA) to market its generic version of Bristol-Myers Squibb's Pravachol(R) (Pravastatin Sodium) Tablets, 10 ... - Black Enterprise,

Pravochol generics arrive  Apr 26, 2006
Under a distribution agreement with Bristol-Myers Squibb, Watson Pharmaceuticals has initiated shipments of pravastatin sodium tablets, its generic version of ... - Pharmaceutical Business Review

Inexpensive Diuretics Best to Treat High Blood Pressure, Prevent ...  May 3, 2006
...medications supplied by Pfizer, Inc (amlodipine and doxazosin), AstraZeneca (atenolol and lisinopril), and Bristol-Myers Squibb (pravastatin) and financial ... - SeniorJournal.com,

Statin Alternatives  May 8, 2006
...six statins are approved by the FDA: atorvastatin (Lipitor®), fluvastatin (Lescol®), lovastatin (Mevacor®), pravastatin (Pravachol®), rosuvastatin (Crestor ... - WHOI,

Statins do not appear to reduce risk of cancer  Apr 17, 2006
...tract, or melanoma when statins were used." The authors continue, "… the patients in our meta-analysis were primarily treated with simvastatin and pravastatin ... - Xagena.it,

Pharm Exec Q&A: Japanese Wedding  May 2, 2006
He had traveled to Japan to meet with Sankyo and secure a license to Pravachol (pravastatin), one of the first statins, which would later become BMS' biggest ... - PharmExec.com,

Ranbaxy breathes easy, net marginally up at Rs 71.4 crore  Apr 19, 2006
Says IDBI Capitals' Shahina Mukadam, "With two large products going off patent (the $4 billion simvastatin and $2 billion pravastatin), Ranbaxy can look ... - Financial Express,

Growth to come in from new products: Biocon  Apr 20, 2006
All depends on how many players there will be when patents expire. Q: Where are Simvastatin and Pravastatin prices at the moment? ... - Moneycontrol.com,

Use of generic drugs would save billions  Apr 21, 2006
Consumers Reports. The cholesterol-lowering statin Pravachol (pravastatin) is scheduled to go generic this month. Zocor (simvastatin ... - Kansas City Star,

FDA OK's Generic Pravachol  Apr 24, 2006
The drug, pravastatin sodium tablets, is indicated for the treatment of high cholesterol levels or for patients who are at heightened risk for atherosclerosis ... - International News Service,

Teva Provides Update on Generic Pravachol(R)  Apr 21, 2006
...of approval of all Abbreviated New Drug Applications (ANDAs) to market a generic version of Bristol-Myers Squibb's Pravachol(R) (Pravastatin Sodium) Tablets. ... - International News Service,

Teva's ANDA For Pravachol Tablets Wins FDA's Final Nod - Quick ...  Apr 25, 2006
Pravastatin Sodium Tablets, Pravachol, are indicated for the treatment of certain hyperlipidemias and the primary prevention of coronary events, Teva stated. ... - Trading Markets,

US District Court Denies Apotex's Request For Blocking Teva's ...  Apr 19, 2006
At Apotex's request, the Court has ordered the FDA to refrain from issuing a final approval for Teva's ANDA for generic pravastatin 10, 20 and 40 mg strengths ... - Trading Markets,

Scientists uncover gene mutation key to cholesterol control  Apr 20, 2006
...in this group include: Lipitor (atorvastatin); Baycol (cerivastatin); Lescol (fluvastatin); Mevacor (lovastatin); Pravachol (pravastatin); Zocor (simvastatin ... - DrugResearcher.com,

Teva Announces Stay of Approval for Generic Pravachol Lifted  Apr 20, 2006
...of approval of its Abbreviated New Drug Application (ANDA) to market its generic version of Bristol-Myers Squibb's Pravachol(R) (Pravastatin Sodium) Tablets ... - PharmaLive.com (press release),

Pfizer profits soar despite slipping revenues  Apr 20, 2006
...in the latter half of the year as two rival products, Merck & Co's Zocor (simvastatin) and Bristol-Myers Squibb's Pravachol (pravastatin), lose patent ... - Pharma Times (subscription),

Teva Announces FDA Determination That Generic Pravachol ...  Apr 12, 2006
March 16, 2006, the US Food and Drug Administration has denied Apotex's request for an agency determination that 180-day exclusivity for pravastatin 10, 20 ... - Business Wire (press release),

Dosage Forms TABLET
Drug_Category Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA03
Absorption Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.
Interactions [an error occurred while processing this directive]Toxicity Rhabdomyolysis; LD50=mg/kg (orally in rat)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 3,5-dihydroxy-7-[6-hydroxy-2-methyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-heptanoicacid
Chemical Formula C23H36O7
Molecular Weight 424.528 g/mol
Smiles String CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)O
Melting Point 326°C
Water Solubility 2464mg/L
State Solid
LogP/Hphobicity 2.613
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 77 hours
Protein Binding [%] 50%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Pravastatin.html
http://www.rxlist.com/cgi/generic/pravast.htm
Drug Type Approved Drug
Accession No APRD00328
CAS Registry Number 81093-37-0
KEGG Compound ID C01844
PubChem ID SID:192211
PharmGKB ID PA451089
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2247008

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