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Pirenzepine
drug data and news
Pirenzepine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Pirenzepine
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| Brand Names/Synonyms |
Bisvanil; CHEMBANK786; Gasteril; Gastrozepin; LS-519; Leblon; P114; Pirenzepin; Pirenzepina [Inn-Spanish]; Pirenzepine; Pirenzepine Gastrozepin; Pirenzepinum [Inn-Latin]; Tabe; Ulcosan |
| Indication |
For the treatment of peptic ulcer; Gastric ulcer; Duodenal ulcer |
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Description |
Not Available |
| Pharmacology |
Pirenzepine belongs to a group of medications called antispasmodics/anticholinergics. These medications are used to relieve cramps or spasms of the stomach, intestines, and bladder. Pirenzepine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness. |
| Mechanism Of Action |
Pirenzepine is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. |
Pirenzepine News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Anti-ulcer Agents; Antimuscarinics; Antispasmodics; ATC:A02BX03 |
| Absorption |
Not Available |
| Interactions |
Drug Interactions:
Pirenzepine may interact with the following drugs, which may affect the effect of Pirenzepine or whose effects may be affected.
- Antacids
- Diarrhea medicine containing kaolin or attapulgite
- Ketoconazole
- Central nervous system (CNS) depressants
- Other anticholinergics
- Tricyclic antidepressants (e.g., Elavil, Asendin, Anafranil, Pertofrane, Sinequan, Tofranil, Aventyl, Surmontil)
- Potassium chloride (e.g., Kay Ciel)
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| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Not Available |
| Chemical Formula |
C19H21N5O2 |
| Molecular Weight |
351.403 g/mol |
| Smiles String |
CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4 |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
0.413 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Pirenzepine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00515 |
| CAS Registry Number |
28797-61-7 |
| KEGG Compound ID |
C07508 |
| PubChem ID |
SID:9711 |
| PharmGKB ID |
PA10159 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
608998
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