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Pipobroman
drug data and news
Pipobroman drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Pipobroman
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| Brand Names/Synonyms |
A 1803; A-8103; Amedel; NSC-25154; Pipobroman; Pipobroman [Usan:Inn]; Pipobromanum [Inn-Latin]; Vercyte |
| Indication |
For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia. |
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Description |
Not Available |
| Pharmacology |
Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia. |
| Mechanism Of Action |
The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death. |
Pipobroman News
(When available) |
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| Dosage Forms |
TABLET (25 mg) |
| Drug_Category |
Antineoplastic Agents; ATC:L01AX02 |
| Absorption |
Well absorbed from the GI tract. |
| Interactions |
Not Available |
| Toxicity |
Symptoms of overdose include hematologic toxicity, especially with chronic overdosage. |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]-propan-1-one |
| Chemical Formula |
C10H16Br2N2O2 |
| Molecular Weight |
356.054 g/mol |
| Smiles String |
C1CN(CCN1C(=O)CCBr)C(=O)CCBr |
| Melting Point |
> 300 °C |
| Water Solubility |
2490 mg/L |
| State |
Solid |
| LogP/Hphobicity |
0.256 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00693 |
| CAS Registry Number |
54-91-1 |
| KEGG Compound ID |
C07362 |
| PubChem ID |
SID:148729 |
| PharmGKB ID |
PA450982 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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