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Piperazine
drug data and news
Piperazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Piperazine | ||
| Brand Names/Synonyms | Anatensol; Antepan; Antepar; Antiren; Asca-Trol No. 3; Bryrel; Dapotum; Diethylenediamine; Diethyleneimine; Dispermine; Entacyl; Eraverm; Fluphenazine Dihydrochloride; Hexahydropyrazine; Lumbrical; Lyogen; Moditen; Multifuge; Omca; Pacinol; Permitil; Piperazidine; Piperazin; Piperazine; Piperazine Anhydrous; Piperazine Citrate; Piperazine, Anhydrous; Pipersol; Prolixin Decanoate; Pyrazine Hexahydride; Pyrazine, Hexahydro-; Siqualone; Tasnon; Tensofin; UN 2579; Upixon; Uvilon; Valamina; Vermex; Vermidol; Worm-Away; Wurmirazin | ||
| Indication | Used as alternative treatment for ascariasis caused by Ascaris lumbricoides(roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Piperazine is an antinematodal agent indicated as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). Piperazine is especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. | ||
| Mechanism Of Action | Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis. | ||
| Piperazine News (When available) |
ImQuest Pharmaceuticals Licenses Piperazine Series of Anti-Cancer ... Apr 26, 2006 Side-effect warning on BZP-based ‘party pills’ Apr 17, 2006 ImQuest licenses anticancer compounds from Samjin Apr 27, 2006 | ||
| Dosage Forms | CAPSULE; DROPS; LIQUID; POWDER; POWDER FOR SOLUTION; SOLUTION; SUSPENSION; SYRUP; TABLET | ||
| Drug_Category | Antinematodal Agents; Anthelmintics; ATC:P02CB01; ATC:R03DA09 | ||
| Absorption | Rapidly absorbed from the gastrointestinal tract | ||
| Interactions | Not Available | ||
| Toxicity | LD50 = 5 g/kg (Human, oral) | ||
| Organisms Affected | Parasitic nematodes and other roundworms | ||
| Chemical IUPAC Name | piperazine | ||
| Chemical Formula | C4H10N2 | ||
| Molecular Weight | 86.1357 g/mol | ||
| Smiles String | C1CNCCN1 | ||
| Melting Point | 106 °C | ||
| Water Solubility | 150 mg/mL | ||
| State | Solid | ||
| LogP/Hphobicity | -0.836 | ||
| Isoelectric Point | 9.73 | ||
| Biotransformation | About 25% is metabolized in the liver | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 60-70% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Piperazine.html http://www.pharmgkb.org/views/index.jsp?objId= | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00225 | ||
| CAS Registry Number | 110-85-0 | ||
| KEGG Compound ID | C07973 | ||
| PubChem ID | SID:261079 | ||
| PharmGKB ID | PA450977 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 97128 |
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