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Picrotoxin
drug data and news
Picrotoxin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Picrotoxin
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| Brand Names/Synonyms |
COCCULINE; Cocculin; Cocculus; Coques Du Levant; Fish Berry; Indian Berry; Oriental Berry; PICROTOXIN; Picrotoxin; Picrotoxin of Fishberries; Picrotoxinin |
| Indication |
For the treatment of respiratory distress |
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Description |
Not Available |
| Pharmacology |
Picrotoxin is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABAA receptors and thus a convulsant. Picrotoxin blocks the research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates. |
| Mechanism Of Action |
Binds to the GABAA and GABA-C receptors and blocks the action of the receptors. |
Picrotoxin News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Anti-barbituates; Stimulants; |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
LD50=15 mg/kg (mice) |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Not Available |
| Chemical Formula |
C30H34O13 |
| Molecular Weight |
602.583 g/mol |
| Smiles String |
CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O |
| Melting Point |
203.5 °C |
| Water Solubility |
2900 mg/L |
| State |
Solid |
| LogP/Hphobicity |
-0.91 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://yosemite.epa.gov/oswer/CeppoEHS.nsf/Profiles/124-87-8?OpenDocument |
| Drug Type |
Non-Approved Drug |
| Accession No |
APRD00269 |
| CAS Registry Number |
124-87-8 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:19294 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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