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Phytonadione
drug data and news
Phytonadione drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Phytonadione | ||
| Brand Names/Synonyms | Phylloquinone; VITAMIN K1; Mephyton (TN); Phytonadione (JP14/USP); AquaMEPHYTON; Aquamephyton; Konakion; M.V.I. Pediatric; Mephyton; Phytonadione; Vitamin K1; Vitaped; α-Phylloquinone; 1,4-Naphthoquinone, 2-methyl-3-phytyl-; 2', 3'-trans-Vitamin K1; 2-Methyl-3-phythyl-1,4-naphthochinon; 3-Phytylmenadione; Antihemorrhagic vitamin; Aqua-Mephytin; Combinal K1; K-Ject; Kativ N; Kephton; Kinadion; Menadione; Mono-Kay; Monodion; Phyllochinon; Phythyl-menadion; Phythyl-menadion (GERMAN); Phytomenadione; Phytylmenadione; Synthex P; Vitamin K; Vitamin K1 (VAN) | ||
| Indication | For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X). | ||
| Mechanism Of Action | Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II, VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phytonadione results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria. | ||
| Phytonadione News (When available) |
France bans vitamin K1 from cosmetic products Apr 26, 2006 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Antifibrinolytic Agents; Vitamins (Vitamin K); | ||
| Absorption | Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues. | ||
| Interactions | Interactions for Phytonadione: Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used. If relatively large doses have been employed, it may be necessary when reinstituting anticoagulant therapy to use somewhat larger doses of the prothrombin-depressing anticoagulant, or to use one which acts on a different principle, such as heparin sodium. Laboratory Tests Prothrombin time should be checked regularly as clinical conditions indicate. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione | ||
| Chemical Formula | C31H46O2 | ||
| Molecular Weight | 450.696 g/mol | ||
| Smiles String | CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C | ||
| Melting Point | -20 °C | ||
| Water Solubility | Insoluble in water | ||
| State | Liquid | ||
| LogP/Hphobicity | 8.841 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Phytonadione.html http://www.rxlist.com/cgi/generic3/phytonadione.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00464 | ||
| CAS Registry Number | 84-80-0 | ||
| KEGG Compound ID | C02059 | ||
| PubChem ID | SID:5148 | ||
| PharmGKB ID | PA450961 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 243876 |
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