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Phenylephrine
drug data and news
Phenylephrine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Phenylephrine | ||
| Brand Names/Synonyms | Adrianol; Ak-Dilate; Ak-Nefrin; Alcon Efrin; Alconefrin Nasal Drops 12; Alconefrin Nasal Drops 25; Alconefrin Nasal Drops 50; Alconefrin Nasal Spray 25; Biomydrin; Dilatair; Dimetane; Dionephrine; Doktors; Duration; Fenilefrina [Inn-Spanish]; HSDB 3383; I-Phrine; Isophrim; Isophrin; Isopto Frin; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; M-Sympathol; M-Sympatol; M-Synephrine; Mesaton; Mesatone; Mesatonum; Metaoxedrin; Metaoxedrine; Metaoxedrinum; Metasympatol; Metasynephrine; Metsatonum; Mezaton; Minims Phenylephrine; Mydfrin; Neo-Synephrine; Neo-Synephrine Nasal Drops; Neo-Synephrine Nasal Jelly; Neo-Synephrine Nasal Spray; Neofrin; Neophryn; Neosynephrine; Nostril; Nostril Spray Pump; Nostril Spray Pump Mild; Ocu-Phrin Sterile Eye Drops; Ocugestrin; Phenoptic; Phenylephrine; Phenylephrine, I-; Phenylephrine, L-; Phenylephrinhydrochlorid; Phenylephrinum [Inn-Latin]; Prefrin; Prefrin Liquifilm; Pyracort D; Relief Eye Drops for Red Eyes; Rhinall; Spersaphrine; Vicks Sinex; Visadron | ||
| Indication | For the treatment of ophthalmic disorders (hyperaemia of conjunctiva, posterior synechiae, acute atopic), nasal congestion, hemorrhoids, hypotension, shock, hypotension during spinal anesthesia, paroxysmal supraventricular tachycardia. It is also used as an aid in the diagnosis of heart murmurs and for prolongation of spinal anesthesia | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Phenylephrine is a powerful vasoconstrictor. It is used as a mydriatic, nasal decongestant, and cardiotonic agent. Phenylephrine is a postsynaptic alpha-receptor stimulant with little effect on the beta receptors of the heart. Parenteral administration of Phenylephrine causes a rise in systolic and diastolic pressures, cardiac output is slightly decreased and peripheral resistance is considerably increased, most vascular beds are constricted; renal, splanchnic, cutaneous, and limb blood flows are reduced but coronary blood flow is increased. Pulmonary vessels are constricted, and pulmonary arterial pressure is raised. This alpha receptor sympathetic agonist is also used locally because its vasoconstrictor and mydriatic action. | ||
| Mechanism Of Action | Phenylephrine produces its ophthalmic and systemic actions by acting on alpha 1 adrenergic receptors in the pupillary dilator muscle and the vascular smooth musle, resulting in contraction of the dilator muscle and contraction of the smooth muscle in the arterioles of the conjunctiva and peripheral vasoconstriction. Phenylephrine decreases nasal congestion by acting on alpha 1 adrenergic receptors in the arterioles of the nasal mucosa to produce constriction. | ||
| Phenylephrine News (When available) |
Federal, state laws prompt decongestant reformulation May 8, 2006 Pseudoephedrine getting harder to find May 9, 2006 Madeleine Brindley, Western Mail May 7, 2006 Springtime allergies: Solutions for a problem in full bloom May 5, 2006 Relief from allergies is confusing Apr 30, 2006 Anti-meth legislation cuts into Perrigo's bottom line Apr 28, 2006 | ||
| Dosage Forms | Ophthalmic Solution; Nasal Solution; Solution (IM, IV, IV infusion and subcutaneous); Gel; Cream; Ointment; Suppository | ||
| Drug_Category | Adrenergic alpha-Agonists; Cardiotonic Agents; Nasal Decongestants; Sympathomimetics; Vasoconstrictor Agents; Mydriatics; ATC:C01CA06; ATC:R01AA04; ATC:R01AB01; ATC:R01BA03; ATC:S01FB01; ATC:S01GA05 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Phenylephrine: Vasopressors, particularly metaraminol, may cause serious cardiac arrhythmias during halothane anesthesia and therefore should be used only with great caution or not at all. MAO Inhibitors The pressor effect of sympathomimetic pressor amines is markedly potentiated in patients receiving monoamine oxidase inhibitors (MAOI). Therefore, when initiating pressor therapy in these patients, the initial dose should be small and used with due caution. The pressor response of adrenergic agents may also be potentiated by tricyclic antidepressants. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-(1-hydroxy-2-methylamino-ethyl)phenol | ||
| Chemical Formula | C9H13NO2 | ||
| Molecular Weight | 167.205 g/mol | ||
| Smiles String | CNCC(C1=CC(=CC=C1)O)O | ||
| Melting Point | 140-145 °C | ||
| Water Solubility | Freely soluble in water | ||
| State | Solid | ||
| LogP/Hphobicity | 0.63 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 95% binding-plasma proteins | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Phenylephrine.html http://www.rxlist.com/cgi/generic3/phenyleph.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00365 | ||
| CAS Registry Number | 59-42-7 | ||
| KEGG Compound ID | C07441 | ||
| PubChem ID | SID:9645 | ||
| PharmGKB ID | PA450935 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2238400 |
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