Phenylbutazone drug data and news

Phenylbutazone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Phenylbutazone

Brand Names/Synonyms

'Esteve'; A 7514; Alindor; Alka Butazolidin; Alkabutazona; Alqoverin; Ambene; Anerval; Anpuzone; Antadol; Anuspiramin; Apo-Phenylbutazone; Arthrizon; Artizin; Artrizin; Artrizone; Artropan; Azdid; Azobutyl; Azolid; B.T.Z.; Benzone; Betazed; Bizolin; Bizolin 200; Bunetzone; Busone; Buta Phen; Butacompren; Butacote; Butadion; Butadiona; Butadione; Butagesic; Butalan; Butalgina; Butalidon; Butaluy; Butapirazol; Butapirazole; Butapyrazole; Butarecbon; Butartril; Butartrina; Butatron; Butazina; Butazolidin; Butazolidine; Butazona; Butazone; Bute; Butidiona; Butiwas-Simple; Butone; Butoz; Butylpyrin; Buvetzone; Buzon; Chembutazone; Cotylbutazone; DA-192; Digibutina; Diossidone; Diozol; Diphebuzol; Diphenylbutazone; Ecobutazone; Elmedal; Equi Bute; Equipalazone; Eributazone; Exrheudon N; Febuzina; Fenartil; Fenibutal; Fenibutasan; Fenibutazona; Fenibutol; Fenilbutazona; Fenilbutina; Fenilbutine; Fenilidina; Fenotone; Fenylbutazon; Flexazone; G 13, 871; Ia-But; Intalbut; Intrabutazone; Intrazone; Ipsoflame; Kadol; Lingel; Malgesic; Mepha-Butazon; Mephabutazon; Mephabutazone; Merizone; NCI-C55414; Nadazone; Nadozone; Neo-Zoline; Novophenyl; PBZ; Phebuzin; Phebuzine; Phenbutazol; Phenbutazone; Phenopyrine; Phenyl-Mobuzon; Phenylbutaz; Phenylbutazone; Phenylbutazonum; Phenyzene; Phenyzone; Pirarreumol &Quot;B&Quot;; Pirarreumol B; Praecirheumin; Pyrabutol; Pyrazolidin; Rectofasa; Reudo; Reudox; Reumasyl; Reumazin; Reumazol; Reumune; Reumuzol; Reupolar; Robizon-V; Robizone; Robizone-V; Rubatone; Scanbutazone; Schemergin; Shigrodin; Tazone; Tencodyne; Tetnor; Tevcodyne; Therazone; Ticinil; Todalgil; Usaf Ge-15; Uzone; VAC-10; Wescozone; Zolaphen; Zolidinum; Zorane

Indication

For the treatment of backache and ankylosing spondylitis

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Description

Not Available

Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Mechanism Of Action

Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Phenylbutazone News
(When available)

NSAIDs: Pain Relief or Pain in the Gut? May 2, 2006
The NSAIDs most commonly used in horses include phenylbutazone ("Bute"), meclofenamic acid (Arquel), flunixin meglumine (Banamine), ketoprofen (Ketofen), and ... - TheHorse.com,

Wound care for sales horses May 9, 2006
It's also important to give an anti-inflammatory, such as Bute [phenylbutazone] or steroids, in moderation, because in some cases this can prevent some of the ... - Thoroughbred Times,

24 hours till 'go' time May 7, 2006
The private veterinarian who works for a trainer will go to the stall and give the horse an injection, most commonly phenylbutazone or "bute.". ... - Louisville Courier-Journal,

Rolex Talk Highlights Performance Horse Issues May 3, 2006
Phenylbutazone is just as good in moderation- Oklahoma State University researchers have determined that a four gram dose of Bute gives no additional benefit ... - TheHorse.com,

Kentucky Issues Advisory on Naproxen Use Apr 20, 2006
...the time the horse is to race. The three NSAIDS are phenylbutazone, flunixin, and ketoprofen. The rule also states that all other ... - TheHorse.com,

Dosage Forms

BOLUS; LIQUID; PASTE; POWDER; SOLUTION; TABLET

Drug_Category

Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:M01AA01; ATC:M02AA01

Absorption

Not Available

Interactions

Not Available

Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione

Chemical Formula

C19H20N2O2

Molecular Weight

308.374 g/mol

Smiles String

CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

Melting Point

105 °C

Water Solubility

47.5 mg/L

State

Solid

LogP/Hphobicity

4.214

Isoelectric Point

4.5

Biotransformation

Not Available

Half Life

Not Available

Protein Binding [%]

Not Available

RxList Link

Not Available>RXlist

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Drug Reference

http://www.drugs.com/cons/Phenylbutazone.html

Drug Type

Approved Drug

Accession No

APRD00409

CAS Registry Number

50-33-9

KEGG Compound ID

C07440

PubChem ID

SID:9644

PharmGKB ID

PA450932

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

596701