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Phentolamine
drug data and news
Phentolamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Phentolamine | ||
| Brand Names/Synonyms | Phenotolamine; Phentalamine; Phentolamine Mesilate; Phentolamine Mesylate; Phentolamine Mesylate [Usan]; Phentolamine Methanesulfonate; Phentolamine Methanesulphonate; Phentolamine, Methyl Sulfonate; Regitin; Regitin Methanesulphonate; Regitine; Regitine Mesylate; Regitine Methanesulfonate; Regitipe; Rogitine | ||
| Indication | Female sexual dysfunction | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phentolamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phentolamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure. | ||
| Mechanism Of Action | Phentolamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. | ||
| Phentolamine News (When available) |
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| Dosage Forms | LIQUID | ||
| Drug_Category | Antihypertensive Agents; Sympatholytics; ATC:C04AB01; ATC:G04BE05 | ||
| Absorption | Not Available | ||
| Interactions | Interactions for Phentolamine: Diagnosis of pheochromocytoma - phentolamine blocking test. The test is most reliable in detecting pheochromocytoma in patients with sustained hypertension and least reliable in those with paroxysmal hypertension. False-positive tests may occur in patients with hypertension without pheochromocytoma. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)-amino]phenol | ||
| Chemical Formula | C17H19N3O | ||
| Molecular Weight | 281.352 g/mol | ||
| Smiles String | CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O | ||
| Melting Point | 174.5 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 2.551 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 19 minutes | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Phentolamine.html http://www.rxlist.com/cgi/generic3/phentol.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00615 | ||
| CAS Registry Number | 50-60-2 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:381231 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2243737 |
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