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Phentermine
drug data and news
Phentermine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Phentermine | ||
| Brand Names/Synonyms | Adipex-P; Alpha,Alpha-Dimethylphenethylamine; Duromine; Fastin; Inoamin; Ionamin; Linyl; Lipopill; Lonamin; Mirapront; Normephentermine; Obenix; Obestin-30; Oby-Trim; Omnibex; Ona Mast; Ona-Mast; Phentercot; Phentermine; Phentermine Hcl; Phentermine Hydrochloride; Phentermine Resin 30; Phentride; Pre-Sate; Pro-Fast; Rcra Waste Number P046; Teramine; Tora; Uritone; Wilpo; Wyamine Sulfate; Zantryl | ||
| Indication | Indicated for the treatment and management of obesity. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. | ||
| Mechanism Of Action | Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage. | ||
| Phentermine News (When available) |
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| Dosage Forms | CAPSULE | ||
| Drug_Category | Adrenergic Agents; Appetite Depressants; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:A08AA01; ATC:C01CA11 | ||
| Absorption | Phentermine is rapidly absorbed after oral ingestion. | ||
| Interactions |
Interactions for Phentermine: Concomitant use of alcohol with phentermine hydrochloride may result in an adverse drug interaction. | ||
| Toxicity | Adult monkeys have an LD50 of 15 to 20 mg/kg. Delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, circulatory collapse. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 2-methyl-1-phenyl-propan-2-amine | ||
| Chemical Formula | C10H15N | ||
| Molecular Weight | 149.233 g/mol | ||
| Smiles String | CC(C)(CC1=CC=CC=C1)N | ||
| Melting Point | Not Available | ||
| Water Solubility | Very soluble | ||
| State | Solid | ||
| LogP/Hphobicity | 2.194 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 16 to 31 hours | ||
| Protein Binding [%] | ~96.3% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Phentermine.html http://www.rxlist.com/cgi/generic/phenterm.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00093 | ||
| CAS Registry Number | 122-09-8 | ||
| KEGG Compound ID | C07438 | ||
| PubChem ID | SID:9642 | ||
| PharmGKB ID | PA450923 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 891770 |
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