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Phensuximide
drug data and news
Phensuximide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Phensuximide
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| Brand Names/Synonyms |
Epimid; Fenosuccimide; Fensuccimide [DCIT]; Fensuximida [INN-Spanish]; Lifene; Methylphenylsuccinimide; Milontin; Milonton; Mirontin; Mirotin; PM 334; Phenosuccimide; Phensuximid; Phensuximide; Phensuximide [BAN:INN]; Phensuximidum [INN-Latin]; Phenylsuximide; Succitimal; (+/-)-N-Methyl-2-phenylsuccinimide; 1-Methyl-3-Phenylsuccinimide; EINECS 201-664-6; Milontin (TN); N-Methyl-alpha-phenolsuccinimide; N-Methyl-alpha-phenylsuccinimide; N-Methyl-2-phenylsuccinimide; N-Methyl-alpha-phenolsuccinimide; N-Methyl-alpha-phenylsuccinimide; Phensuximide (USP); Succinimide, N-methyl-2-phenyl- |
| Indication |
For the treatment of epilepsy |
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Description |
Not Available |
| Pharmacology |
Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. |
| Mechanism Of Action |
Phensuximide's mechanism of action not understood, but may act in inhibitory neuronal systems that are important in the generation of the three per second rhythm |
Phensuximide News
(When available) |
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| Dosage Forms |
CAPSULES |
| Drug_Category |
Anticonvulsants; Antiepileptic Agents; ATC:N03AD02 |
| Absorption |
Rapid and complete |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
1-methyl-3-phenyl-pyrrolidine-2,5-dione |
| Chemical Formula |
C11H11NO2 |
| Molecular Weight |
189.211 g/mol |
| Smiles String |
CN1C(=O)CC(C1=O)C2=CC=CC=C2 |
| Melting Point |
72 °C |
| Water Solubility |
7020 mg/L |
| State |
Solid |
| LogP/Hphobicity |
1.079 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Hepatic |
| Half Life |
Not Available |
| Protein Binding [%] |
21% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00496 |
| CAS Registry Number |
86-34-0 |
| KEGG Compound ID |
C07437 |
| PubChem ID |
SID:9641 |
| PharmGKB ID |
PA450922 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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