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Phenprocoumon
drug data and news
Phenprocoumon drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Phenprocoumon
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| Brand Names/Synonyms |
4oh-Coumarin Deriv.; Falithiom; Falithrom; Fencumar; Fenprocumone [Dcit]; Liquamar; Marcoumar; Marcumar; PHENPROCOUMON; Phenprocoumarol; Phenprocoumarole; Phenprocoumon Ala-Nh Deriv.; Phenprocumone; Phenprocumonum |
| Indication |
Used in the management of thromboembolic disorders |
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Description |
Not Available |
| Pharmacology |
Phenprocoumon, a coumarin anticoagulant, is a racemic mixture of two active isomers. It is used in the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF). |
| Mechanism Of Action |
inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. |
Phenprocoumon News
(When available) |
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| Dosage Forms |
TABLETS |
| Drug_Category |
Anticoagulants; ATC:B01AA04 |
| Absorption |
Bioavailability is close to 100% |
| Interactions |
Not Available |
| Toxicity |
50=500 mg/kg |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-hydroxy-3-(1-phenylpropyl)chromen-4-one |
| Chemical Formula |
C18H16O3 |
| Molecular Weight |
280.318 g/mol |
| Smiles String |
CCC(C1=CC=CC=C1)C2=C(OC3=CC=CC=C3C2=O)O |
| Melting Point |
179.5 °C |
| Water Solubility |
12.9 mg/L |
| State |
Solid |
| LogP/Hphobicity |
4.59 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Primarily hepatic |
| Half Life |
2.5-3.5 days |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00228 |
| CAS Registry Number |
435-97-2 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:153131 |
| PharmGKB ID |
PA450921 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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