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Phenoxybenzamine
drug data and news
Phenoxybenzamine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Phenoxybenzamine | ||
| Brand Names/Synonyms | 688A; A 688; B019; Bensylyt; Bensylyt Nen; Bensylyte; Benzylyt; Blocadren; CCRIS 505; CHEMBANK1395; Dibenylin; Dibenyline; Dibenzylene; Dibenzyline; Dibenzyline Hydrochloride; Dibenzyran; Fenossibenzamina [Dcit]; Fenoxibenzamina [Inn-Spanish]; HSDB 4005; Phenoxybenzamine; Phenoxybenzamine Hcl; Phenoxybenzamine Hydrochloride; Phenoxybenzaminum [Inn-Latin]; Phenyoxybenzaminehydrochloride; Pob Hcl | ||
| Indication | Phaeochromocytoma (malignant);Benign prostatic hypertrophy;Malignant essential hypertension | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure. | ||
| Mechanism Of Action | Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. | ||
| Phenoxybenzamine News (When available) |
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| Dosage Forms | Not Available | ||
| Drug_Category | Vasodilator Agents; Antihypertensive Agents; ATC:C04AX02 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Phenoxybenzamine: Dibenzyline (phenoxybenzamine hydrochloride) may interact with compounds that stimulate both alpha- and beta- adrenergic receptors (i.e., epinephrine) to produce an exaggerated hypotensive response and tachycardia. Dibenzyline blocks hyperthermia production by levarterenol, and blocks hypothermia production by reserpine. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N-benzyl-N-(2-chloroethyl)-1-phenoxy-propan-2-amine | ||
| Chemical Formula | C18H22ClNO | ||
| Molecular Weight | 303.826 g/mol | ||
| Smiles String | CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2 | ||
| Melting Point | 39 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 4.601 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 24 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Phenoxybenzamine.html http://www.rxlist.com/cgi/generic3/phenoxybenz.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00651 | ||
| CAS Registry Number | 59-96-1 | ||
| KEGG Compound ID | C07435 | ||
| PubChem ID | SID:9639 | ||
| PharmGKB ID | PA450919 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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