| Generic name |
Phenacemide
|
| Brand Names/Synonyms |
A-1348; Acetylureum; Carbamide Phenylacetate; Carbanmide; Cetylureum; Comitiadone; Eferon; Efron; Epheron; Epiclase; Felurea; Fenacemid; Fenacemide; Fenacetamide; Fenacetil-Karbamide; Fenilep; Fenised; Fenostenyl; Fenural; Fenurea; Fenurone; Fenylacetylmocovina; Fenytan; Neophedan; Neophenal; PA; Phacetur; Phenacalum; Phenacemide; Phenacereum; Phenacetur; Phenacetylcarbamide; Phenacetylurea; Phenarone; Phenicarb; Phenuron; Phenurone; Phenutal; Phenylacetylurea; Phenylacetyluree; Phenyrit; Phetylureum; Trioxanona |
| Indication |
Used to control certain seizures in the treatment of epilepsy. |
|
Sponsored links
|
|
Description |
Not Available |
| Pharmacology |
Phenacemide is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures, refractory to other anticonvulsants. Phenacemide elevates the threshold for minimal electroshock convulsions and abolishes the tonic phase of maximal electroshock seizures. It also prevents or modifies seizures induced by pentylenetetrazol or other convulsants. |
| Mechanism Of Action |
Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures. |
Phenacemide News
(When available) |
[an error occurred while processing this directive] |
| Dosage Forms |
TABLET |
| Drug_Category |
Anticonvulsants; ATC:N03AX07 |
| Absorption |
Almost completely absorbed. |
| Interactions |
Not Available |
| Toxicity |
Oral, mouse: LD50 = 987 mg/kg; Oral, rabbit: LD50 = 2500 mg/kg; Oral, rat: LD50 = 1600 mg/kg |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
N-carbamoyl-2-phenyl-ethanamide |
| Chemical Formula |
C9H10N2O2 |
| Molecular Weight |
178.188 g/mol |
| Smiles String |
C1=CC=C(C=C1)CC(=O)NC(=O)N |
| Melting Point |
215 °C |
| Water Solubility |
1.02E+004 mg/L |
| State |
Solid |
| LogP/Hphobicity |
1.07 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation. |
| Half Life |
22-25 hours. |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
|
Sponsored links
|
|
| Drug Reference |
http://www.drugs.com/cons/Phenacemide.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00089 |
| CAS Registry Number |
63-98-9 |
| KEGG Compound ID |
C07428 |
| PubChem ID |
SID:9632 |
| PharmGKB ID |
PA450896 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
|
