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Pentolinium
drug data and news
Pentolinium drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Pentolinium
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| Brand Names/Synonyms |
Ansolysen; Pentolinium; Pentolinium Tartrate; Pentolonium; Pentolonum |
| Indication |
Used to produce controlled hypotension during surgical procedures and in hypertensive crises. |
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Description |
Not Available |
| Pharmacology |
Acts as a ganglionic blocking agent. Pentolinium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously. |
| Mechanism Of Action |
Binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton. |
Pentolinium News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Antihypertensive Agents |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg. |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
1-methyl-1-[5-(1-methyl-2,3,4,5-tetrahydropyrrol-1-yl)pentyl]-2,3,4,5-tetrahydropyrrole |
| Chemical Formula |
C15H32N2 |
| Molecular Weight |
240.428 g/mol |
| Smiles String |
C[N+]1(CCCC1)CCCCC[N+]2(CCCC2)C |
| Melting Point |
213 oC (tartarate salt) |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
Not Available |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00038 |
| CAS Registry Number |
52-62-0 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:741991 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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