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Pegaspargase
drug data and news
Pegaspargase drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Pegaspargase | ||
| Brand Names/Synonyms | Putative L-asparaginase precursor;L-asparagine amidohydrolase; Oncaspar (Enzon Inc) | ||
| Indication | For treatment of acute lymphoblastic leukemia | ||
| Sponsored links | Description | Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life. | |
| Pharmacology | In a significant number of patients with acute leukemia, the malignant cells are dependent on an exogenous source of asparagine for survival. Normal cells, however, are able to synthesize asparagine and thus are affected less by the rapid depletion produced by treatment with the enzyme asparaginase. Oncaspar exploits a metabolic defect in asparagine synthesis of some malignant cells. | ||
| Mechanism Of Action | Asparaginase converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death. | ||
| Pegaspargase News (When available) |
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| Dosage Forms | LIQUID | ||
| Drug_Category | Antineoplastic Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Pegylated E. coli L-asparagine amidohydrolase | ||
| Chemical Formula | C1377H2208N382O442S17 | ||
| Molecular Weight | 31731.9 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | 0.059 | ||
| Isoelectric Point | 4.67 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Pegaspargase.html http://www.rxlist.com/cgi/generic2/pegaspargase.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00079 | ||
| CAS Registry Number | 130167-69-0 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA450833 | ||
| SwissProt ID | ASGX_ECOLI (P37595) | ||
| GenBank ID | U00096 | ||
| Drug ID Number [DIN] | 2236849 |
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