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Pegademase bovine
drug data and news
Pegademase bovine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Pegademase bovine
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| Brand Names/Synonyms |
Adenosine deaminase;Adenosine aminohydrolase; Adagen (Enzon Inc.) |
| Indication |
For treatment of adenosine deaminase deficiency |
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Description |
Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life |
| Pharmacology |
Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adensoine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function. |
| Mechanism Of Action |
Converts adenosine (toxic) to inosine (less toxic) by deamination. Also converts 2'-deoxyadenosine to 2’-deoxyinosine via deamination. |
Pegademase bovine News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Enzyme replacement |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
bovine adenosine deaminase (PEGylated) |
| Chemical Formula |
C1821H2834N484O552S14 |
| Molecular Weight |
40788.2 |
| Smiles String |
Not Available |
| Melting Point |
MacQuarrie R, Buel E. Physical and catalytic properties of the isozymes of adenosine deaminase from human red blood cells. Mol Cell Biochem. 1982 Oct 18;48(2):121-6 |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.428 |
| Isoelectric Point |
5.33 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.rxlist.com/cgi/generic2/pegademase.htm |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00100 |
| CAS Registry Number |
9026-93-1 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA450832 |
| SwissProt ID |
ADA_BOVIN (P56658) |
| GenBank ID |
AF280603 |
| Drug ID Number [DIN] |
Not Available
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