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Paroxetine
drug data and news
Paroxetine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Paroxetine | ||
| Brand Names/Synonyms | Aropax; FG 7051; Paroxetina [Inn-Spanish]; Paroxetine; Paroxetine Hcl; Paroxetine [Usan:Ban:Inn]; Paroxetinum [Inn-Latin]; Paxil; Paxil Cr; Pexeva; Seroxat | ||
| Indication | For the treatment of depression, depression accompanied by anxiety, obsessive compulsive disorder and panic attacks | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Paroxetine, an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type, has no active metabolites and has the highest specificity for serotonin receptors of all the SSRIs. It is used to treat depression resistant to other antidepressants, depression complicated by anxiety, panic disorder, social and general anxiety disorder, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder, premature ejaculation, and hot flashes of menopause in women with breast cancer. | ||
| Mechanism Of Action | Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the neuronal membrane, enhances serotonergic neurotransmission by reducing turnover of the neurotransmitter, therefore it prolongs its activity at synaptic receptor sites and potentiates 5-HT in the CNS; paroxetine is more potent than both sertraline and fluoxetine in its ability to inhibit 5-HT reuptake. Compared to the tricyclic antidepressants, SSRIs have dramatically decreased binding to histamine, acetylcholine, and norepinephrine receptors. | ||
| Paroxetine News (When available) |
ABILIFY (Aripiprazole) Demonstrated Efficacy as Maintenance ... 16 May 2006 Treatment options are limited 16 May 2006 Paroxetine: increased risk of suicidal behavior in young adults May 13, 2006 Warning: Antidepressant Paxil may raise suicide risk in young ... May 15, 2006 Paxil/Paxil CR and Recent Meta-Analysis of Paroxetine Showed a ... May 12, 2006 Combined Psychotherapy and Pharmacotherapy for Mood and Anxiety ... May 15, 2006 Paxil increases suicidal attempts in adults May 13, 2006 FDA: Paxil linked to increased suicide risk in young adults May 13, 2006 GlaxoSmithKline, FDA Warn Paxil May Increase Suicide Risk In Young ... May 13, 2006 Implications of Research in Cognitive Neuroscience for ... May 15, 2006 Paxil Suicide Risk in Young Adults May 12, 2006 Patient Management Exercise FOR PSYCHOTHERAPY May 15, 2006 FDA Requires Makers of Paxil to Include Warning of Suicide Risks ... May 12, 2006 Suicidal acts cited in adults on Glaxo's Paxil May 12, 2006 Paxil's maker, FDA warn of suicide risk May 13, 2006 US cites suicidal acts on Paxil May 13, 2006 Across the nation May 13, 2006 Alternatives to Estrogen for Treatment of Hot Flashes May 2, 2006 Tuesday, May 2, 2006, 4:54 pm May 2, 2006 GlaxoSmithKline warns Paxil may raise suicide risk May 12, 2006 Antidepressant linked to suicide risk in adults May 12, 2006 Paxil Linked to Increased Suicidal Behavior in Young Adults May 12, 2006 Paxil and the risk of birth defects May 10, 2006 Nation briefs May 12, 2006 SkyePharma PLC - Preliminary Results Announcement for the Year ... Apr 19, 2006 UPDATE:GlaxoSmithKline Warns Paxil May Raise Suicide Risk May 12, 2006 GlaxoSmithKline,FDA Notify Doctors Of Paxil Suicide Risk May 12, 2006 Antidepressants: Weighing the Decision Apr 20, 2006 Nonhormonal Drugs Ease Hot Flashes, Study Says May 2, 2006 Some non-estrogen therapies may relieve hot flashes May 3, 2006 Study lukewarm on non-hormone drugs against hot flashes May 3, 2006 Study Finds Few Therapies Work Well on Hot Flashes May 3, 2006 Non-Hormone Therapies Offer Some Hot-Flash Relief May 2, 2006 Hot flashes, cold facts May 8, 2006 Study favors hormones for hot flashes May 7, 2006 Nonhormonal Therapies May Offer Relief From Hot Flashes, With ... May 3, 2006 Many Hot Flash Remedies a Flash in the Pan May 2, 2006 Lundbeck files application for approval of Cipralex for the ... Apr 28, 2006 Popular antidepressants may affect fetus Apr 20, 2006 | ||
| Dosage Forms | Tablet | ||
| Drug_Category | Antidepressants; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB05 | ||
| Absorption | completely absorbed after oral dosing | ||
| Interactions | [an error occurred while processing this directive]Toxicity | LD50=500mg/kg (orally in mice); Coma, dizziness, drowsiness, facial flushing, nausea, sweating, tremor, vomiting | |
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)-piperidine | ||
| Chemical Formula | C19H20FNO3 | ||
| Molecular Weight | 329.365 g/mol | ||
| Smiles String | C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4 | ||
| Melting Point | 129-131 °C | ||
| Water Solubility | Not Available | ||
| State | odorless, off-white powder | ||
| LogP/Hphobicity | 3.369 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 24 hours | ||
| Protein Binding [%] | 95% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Paroxetine.html http://www.rxlist.com/cgi/generic/parox.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00364 | ||
| CAS Registry Number | 61869-08-7 | ||
| KEGG Compound ID | C07415 | ||
| PubChem ID | SID:9619 | ||
| PharmGKB ID | PA450801 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2262746 |
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