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Papaverine
drug data and news
Papaverine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Papaverine | ||
| Brand Names/Synonyms | Alapav; Artegodan; Cardiospan; Cardoverina; Cepaverin; Cerebid; Cerespan; Chlorhydrate de Papaverine; Delapav; Dilaves; Dispamil; Drapavel; Durapav; Dynovas; Forpavin; Genabid; HSDB 3147; Myobid; Optenyl; PAPAVERINE; Pameion; Pamelon; Panergon; Pap H; Papacon; Papalease; Papanerin; Papanerin-Hcl; Papanerine; Papavarine Chlorhydrate; Papaverin; Papaverine Chlorohydrate; Papaverine Hcl; Papaverine Hydrochloride; Papaverine Monohydrochloride; Papaverine, Hydrochloride; Papaverinium Chloride; Papaversan; Papital T.R.; Paptial T.R.; Pavabid; Pavabid Hp; Pavacap; Pavacels; Pavacen; Pavacot; Pavadel; Pavagen; Pavakey; Pavarine; Pavased; Pavatest; Pavatine; Pavatym; Paverolan; Paveron; Pavnell; Qua Bid; Ro-Papav; Robaxapap; Spasmo-Nit; Therapav; Vasal; Vaso-Pav; Vasospan | ||
| Indication | Impotence | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system. Papaverine relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries. | ||
| Mechanism Of Action | Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy. | ||
| Papaverine News (When available) |
Love’sa step ahead of MS Apr 24, 2006 Vanilla's Value Apr 25, 2006 | ||
| Dosage Forms | LIQUID | ||
| Drug_Category | Vasodilator Agents; Vasodilator Agents; ATC:A03AD01; ATC:G04BE02 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Papaverine: No information provided. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline | ||
| Chemical Formula | C20H21NO4 | ||
| Molecular Weight | 339.385 g/mol | ||
| Smiles String | COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 3.72 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 0.5-2 hours | ||
| Protein Binding [%] | ~90% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Papaverine.html http://www.rxlist.com/cgi/generic/papaverine.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00628 | ||
| CAS Registry Number | 61-25-6 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:65854 | ||
| PharmGKB ID | PA450779 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 9881 |
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