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Pancrelipase
drug data and news
Pancrelipase drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Pancrelipase | ||
| Brand Names/Synonyms | Pancreatic alpha-amylase precursor;PA;1,4-alpha-D- glucan glucanohydrolase; Pancrease (Ortho-McNeil); Cotazym (Organon); Ku-Zyme (Koichi); Ultrase (Axcan Scandipharm); Zymase (Organon) | ||
| Indication | For treatment of cystic fibrosis, chronic pancreatitis, pancreatic duct blockage | ||
| Sponsored links | Description | Protein mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. Contains 3 enzymes, amylase, lipase and a protease (chymotrypsin). | |
| Pharmacology | Used in the treatment of cystic fibrosis or pancreatic dysfunction, pancrelipase helps improve fat digestion in the small intestine. Specifically, the lipase, protease and amylase components break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. Pancreatic enzymes are used to correct maldigestion, malabsorption and pain associated with pancreatic insufficiency. The major maldigestion/malabsorption problems arise from incomplete fat digestion. Exogenous pancrelipase reduces the amount of nitrogen and fat excreted in the stool. | ||
| Mechanism Of Action | The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. | ||
| Pancrelipase News (When available) |
Axcan announces record revenue of $72.8 million for the second ... May 4, 2006 | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Enzyme replacement; enzymes (44:00.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | C5850H8902N1606O1739S49 >pancreatic triacylglycerol lipase >chymotrypsin B | ||
| Molecular Weight | 131125.6 | ||
| Smiles String | Not Available | ||
| Melting Point | 48-50 oC (Vinogradov, A.A. et al., Protein Eng. 14:683-689 (2001)). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | 6.44 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Pancrelipase.html http://www.rxlist.com/cgi/generic2/pancrel.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00067 | ||
| CAS Registry Number | 53608-75-6 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA450770 | ||
| SwissProt ID | AMYP_HUMAN (P04746) | ||
| GenBank ID | M18785 | ||
| Drug ID Number [DIN] | 783382 |
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