|
|
|
|
|
Palifermin
drug data and news
Palifermin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Palifermin | ||
| Brand Names/Synonyms | Keratinocyte growth factor precursor;KGF;Fibroblast growth factor- 7;FGF-7;HBGF-7; Kepivance (Amgen Inc) | ||
| Indication | For treatment of mucositis (mouth sores) | ||
| Sponsored links | Description | Human keratinocyte growth factor (KGF), 140 residues long, expressed in E. coli. First 23 residues removed to improve stability. | |
| Pharmacology | Used in the prevention or treatment of oral mucoscitis (mouth ulcers arising from chemotherapy), Kepivance binds to the human keratinocyte growth factor (KGF) receptor on buccal cell surfaces. Kepivance acts as both a cell growth and survival factor by stimulating epithelial cell proliferation, differentiation, and migration around the tongue and mouth. The KGF receptor is found on many tissues particularly around the tongue, esophagus, salivary gland and other gastro-intestinal tract organs. | ||
| Mechanism Of Action | Kepivance binds to the human keratinocyte growth factor (KGF) receptor found on buccal cell surfaces. The binding activates a Ras-MapK (Map kinase) signaling pathway which leads to the transcriptional activation of many proteins important for cell growth and survival. | ||
| Palifermin News (When available) |
Kepivance™ Improves Patient-Assessed Oral Mucositis Following ... Apr 21, 2006 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Antimucositis Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human keratinocyte growth factor | ||
| Chemical Formula | C721H1142N202O204S9 | ||
| Molecular Weight | 16192.7 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.65 | ||
| Isoelectric Point | 9.47 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | Not Available | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00042 | ||
| CAS Registry Number | 162394-19-6 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | FGF7_HUMAN (P21781) | ||
| GenBank ID | M60828 | ||
| Drug ID Number [DIN] | Not Available |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |