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Oxytetracycline
drug data and news
Oxytetracycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Oxytetracycline | ||
| Brand Names/Synonyms | Oxytetracycline; Oxytetracycline Anhydrous; Oxytetracycline Hcl; Terramycin | ||
| Indication | Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Oxytetracycline, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Oxytetracycline is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections. | ||
| Mechanism Of Action | Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. | ||
| Oxytetracycline News (When available) |
Club Feet Apr 24, 2006 | ||
| Dosage Forms | DRUG PREMIX | ||
| Drug_Category | Anti-bacterial Agents; Tetracyclines; ATC:D06AA03; ATC:G01AA07; ATC:J01AA06; ATC:S01AA04 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Oxytetracycline: No Information Provided | ||
| Toxicity | Not Available | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 2-(amino-hydroxy-methylidene)-4-dimethylamino-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione | ||
| Chemical Formula | C22H24N2O9 | ||
| Molecular Weight | 460.434 g/mol | ||
| Smiles String | CC1(C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O)O | ||
| Melting Point | 183 °C | ||
| Water Solubility | 0.6 mg/mL (6.9 mg/mL as HCl salt) | ||
| State | Solid | ||
| LogP/Hphobicity | -2.078 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Oxytetracycline.html http://www.rxlist.com/cgi/generic2/oxytetracycline.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00019 | ||
| CAS Registry Number | 79-57-2 | ||
| KEGG Compound ID | C06624 | ||
| PubChem ID | SID:8850 | ||
| PharmGKB ID | PA450757 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 719315 |
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