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Oxybutynin
drug data and news
Oxybutynin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Oxybutynin | ||
| Brand Names/Synonyms | CCRIS 1923; CHEMBANK1678; Ditropan; Ditropan Xl; Ditropan Xl;; HSDB 3270; Oxibutinina [Inn-Spanish]; Oxibutyninum; Oxybutinin; Oxybutynin; Oxybutynin Base; Oxybutynin Chloride; Oxybutynin Hydrochloride; Oxybutynine [Inn-French]; Oxybutyninum [Inn-Latin]; Oxytrol | ||
| Indication | For the treatment of overactive bladder | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Oxybutynin is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Oxybutynin relaxes bladder smooth muscle. Oxybutynin exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. Antimuscarinic activity resides predominantly in the R-isomer. | ||
| Mechanism Of Action | Oxybutynin exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects). | ||
| Oxybutynin News (When available) |
Antares Pharma Reports First Quarter 2006 Financial Results May 15, 2006 Watson Pharmaceuticals Reports First Quarter 2006 Results May 9, 2006 Report Shows Popular Birth Control Pill, Ortho Tri-Cyclen(R) LO ... May 11, 2006 CAN WATER TAKE WEIGHT OFF? Apr 19, 2006 Weight loss probably not due to drinking gallons of water Apr 20, 2006 Utah patent filings Apr 18, 2006 | ||
| Dosage Forms | PATCH; SYRUP; TABLET; TABLET (EXTENDED-RELEASE) | ||
| Drug_Category | Anticholinergic Agents; Antispasmodics; Genitourinary Smooth Muscle Relaxants; ATC:G04BD04 | ||
| Absorption | Rapidly absorbed from gastrointestinal tract. | ||
| Interactions |
-->Interactions for Oxybutynin: The concomitant use of oxybutynin with other anticholinergic drugs or with other agents which produce dry mouth, constipation, somnolence (drowsiness), and/or other anticholinergic-like effects may increase the frequency and/or severity of such effects. Anticholinergic agents may potentially alter the absorption of some concomitantly administered drugs due to anticholinergic effects on gastrointestinal motility. This may be of concern for drugs with a narrow therapeutic index. Mean oxybutynin chloride plasma concentrations were approximately 2 fold higher when DITROPAN XL was administered with ketoconazole, a potent CYP3A4 inhibitor. Other inhibitors of the cytochrome P450 3A4 enzyme system, such as antimycotic agents (e.g., itraconazole and miconazole) or macrolide antibiotics (e.g., erythromycin and clarithromycin), may alter oxybutynin mean pharmacokinetic parameters (i.e., Cmax and AUC). The clinical relevance of such potential interactions is not known. Caution should be used when such drugs are co-administered. Concurrent ingestion of antacid (20 mL of antacid containing aluminum hydroxide, magnesium hydroxide, and simethicone) did not significantly affect the exposure of oxybutynin or desethyloxybutynin. | ||
| Toxicity | Oral (rats) LD50: 1220 mg/kg (Goldenthal) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 4-diethylaminobut-2-ynyl2-cyclohexyl-2-hydroxy-2-phenyl-ethanoate | ||
| Chemical Formula | C22H31NO3 | ||
| Molecular Weight | 357.486 g/mol | ||
| Smiles String | CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O | ||
| Melting Point | 129-130 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 4.683 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic, primarily by CYP3A4 | ||
| Half Life | 12.4-13.2 hours | ||
| Protein Binding [%] | 91%-93% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dit1143.shtml http://www.drugs.com/cons/Oxybutynin.html http://www.rxlist.com/cgi/generic/ditropan.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00427 | ||
| CAS Registry Number | 5633-20-5 | ||
| KEGG Compound ID | C07360 | ||
| PubChem ID | SID:164556 | ||
| PharmGKB ID | PA450737 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2260751 |
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