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OspA lipoprotein
drug data and news
OspA lipoprotein drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
OspA lipoprotein
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| Brand Names/Synonyms |
Outer surface protein A precursor; LYMErix (SmithKline Beecham) |
| Indication |
For prophylactic treatment of Lyme Disease |
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Description |
Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli. Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded to the N terminus. It is conjugated with alum (aluminum hydroxide) as an adjuvant. |
| Pharmacology |
Not Available |
| Mechanism Of Action |
Not Available |
OspA lipoprotein News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Vaccine |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Borrelia outer surface protein A (OspA) |
| Chemical Formula |
C1198H2012N322O422S2 |
| Molecular Weight |
27743.1 |
| Smiles String |
Not Available |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.652 |
| Isoelectric Point |
6.72 |
| Biotransformation |
Not Available |
| Half Life |
1.2 hours (mammalian reticulocytes, in vitro). |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00054 |
| CAS Registry Number |
Not Available |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
Not Available |
| SwissProt ID |
OSPA1_BORBU (P14013) |
| GenBank ID |
X16467 |
| Drug ID Number [DIN] |
Not Available
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