Nortriptyline drug data and news

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Brain white-matter hyperintensities and treatment outcome in major ...  Feb 8, 2006
...at Massachusetts General Hospital for a clinical trial in people with treatment-resistant depression, beginning with open-label nortriptyline (Nierenberg et al ... - British Journal of Psychiatry (subscription),

STAR*D Preliminary Findings Provide Clearer Picture of Major ...  Feb 27, 2006
...after two adequate trials with antidepressants could proceed to Level 3. Options at Level 3 were mirtazapine (Remeron) or nortriptyline (Aventyl, Pamelor) as ... - Psychiatric Times,

Hepatitis C Treatment for People With Severe Mental Illness  Feb 28, 2006
Goldman LS: Successful treatment of interferon alfa-induced mood disorder with nortriptyline. Psychosomatics 1994; 35:412–413[Medline]. ... - Psychosomatics (subscription)

Antidepressants: Are they safe during pregnancy?  Feb 22, 2006
These older antidepressants — including amitriptyline and nortriptyline (Aventyl, Pamelor) — are generally discouraged during pregnancy in favor of newer ... - MayoClinic.com

Health Tip: Drugs to Avoid While Breast-Feeding  Feb 16, 2006
Amitriptyline, Amoxapine, Bupropion, Clomipramine, Desipramine, Dothiepin, Doxepin, Fluoxetine, Fluvoxamine, Imipramine, Nortriptyline, Paroxetine, Sertraline ... - Forbes

Consumer Reports Medical Guide Addresses Differing Side Effects of ...  Feb 10, 2006
Medical Guide can access detailed information about the safe use of drugs addressed in the report including fluoxetine (Prozac), nortriptyline (Aventyl, Pamelor ... - U.S. Newswire (press release),

Six Months of Treatment for Depression: Outcome and Predictors of ...  Jan 24, 2006
Patients were initially randomly assigned to fluoxetine or nortriptyline. ... At 6 weeks the mean nortriptyline dose was 93.5 mg/day (range=50–175). ... - Am J Psychiatry (subscription)

Comorbid Tobacco Dependence and Psychiatric Disorders  Jan 23, 2006
Nortriptyline (Aventyl, Pamelor) (Hall et al., 1998) and bupropion (Hayford et al., 1999) have shown promise as smoking cessation aids while SSRIs do not ... - Psychiatric Times,

Ask the Clinician: Answers to Readers' Questions  Jan 9, 2006
The neurologist has given me nortriptyline in a progression from 10 - 40 mg daily as a preventative... Do you know if nortriptyline has any impact on cortisol? ... - About - News & Issues,

Jaw malady continues to be poorly understood  Jan 29, 2006
...participants from 18 to 65 who have had TMJ pain for at least three months randomly are assigned to take either the antidepressant nortriptyline – which has ... - Fort Wayne Journal Gazette,

Brief Reports: Patterns of Psychotropic Medication Use by Race ...  Jan 25, 2006
Tricyclics included ami-triptyline, amitriptyline pamoate, clomi-pramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine, and ... - Psychiatric Services (subscription)

Income may influence antidepressant response  Jan 13, 2006
...between socioeconomic status and treatment response in 248 depressed adults participating in trials of the antidepressants Pamelor (nortriptyline) or Paxil ... - Reuters.uk,

Six Months of Treatment for Depression: Outcome and Predictors of ...  Jan 24, 2006
Patients were initially randomly assigned to fluoxetine or nortriptyline. Those who responded were encouraged to continue taking their drugs for the 6 months. ... - Am J Psychiatry (subscription)

An open and shut case  Dec 10, 2005
...participants from 18 to 65 who have had TMJ pain for at least three months randomly are assigned to take either the antidepressant nortriptyline — which has ... - Seattle Times,

ABC News' Dr. Tim Answers Questions About Smoking  Nov 11, 2005
There are three other medications that can be used: nortriptyline, clonidine, and mecamylamine. Like Zyban, Nortriptyline is also ... - ABC News

Evaluation of Reboxetine, a Noradrenergic Antidepressant, for the ...  Sep 23, 2005
...an acceptable duration at the maximum tolerated dose) of several antidepressant medications, including fluoxetine, paroxetine, nortriptyline, and amitryptyline ... - Psychosomatics (subscription)

Prevalence and Treatment of Depression in Parkinson’s Disease  Sep 24, 2005
...these receptors. The TCAs include the following: amitriptyline, nortriptyline, imipramine, desipramine, and doxepine. These medications ... - Journal of Neuropsychiatry (subscription)

Impact of Cluster C Personality Disorders on Outcomes of Acute and ...  Sep 24, 2005
Acute treatment included weekly interpersonal psychotherapy (IPT) 14 and nortriptyline (steady-state target level of 80 mg/ml –120 mg/ml). ... - Am J Geriatric Psychiatry (subscription)

Breaking the Teeth -- Grinding Habit  Sep 22, 2005
They include the benzodiazepine drug clonazepam (Klonopin, others) and tricyclic antidepressants such as nortriptyline (Aventyl, Pamelor, others). ... - Newswise (press release)

Many meds don't mix with the sun  Sep 21, 2005
...fluvoxamine (Luvox), imipramine (To-franil), maprotiline (Ludiomil), mirtazapine (Remeron), nefazo-done (Serzone), nortriptyline (Pamelor), paroxetine (Paxil ... - Pioneer Press,

Evaluation of Reboxetine, a Noradrenergic Antidepressant, for the ...  Sep 6, 2005
...an acceptable duration at the maximum tolerated dose) of several antidepressant medications, including fluoxetine, paroxetine, nortriptyline, and amitryptyline ... - Psychosomatics (subscription)

Prognosis of Depression in Old Age Compared to Middle Age: A ...  Aug 31, 2005
We identified one inception cohort study that involved ECT, one that used pharmacotherapy, and one that compared nortriptyline with interpersonal psychotherapy ... - Am J Psychiatry (subscription)

Seizures After a Bier Block with Clonidine and Lidocaine: Is ...  Aug 22, 2005
...the likely cause of seizure in this case is multifactorial, as we pointed out in the report, including the possible role of nortriptyline, potentially lowering ... - Anesthesia & Analgesia (subscription),

Best Treatments for Lasting Shingles Pain  Jul 25, 2005
Those shown effective for postherpetic neuralgia include nortriptyline (Pamelor), desipramine (Norpramin), and amitriptyline (Elavil, Endep). Strong opioids. ... - WebMD

What to Do With a Patient Who Smokes  Jul 26, 2005
Service has recommended as second-line agents for cessation 2 centrally active medications currently used for other conditions: nortriptyline, a tricyclic ... - Journal of American Medical Association (subscription)

Palliative Pain Management: When Both Pain and Suffering Hurt  Jul 15, 2005
...pain. She had stable major depression treated with nortriptyline, and an anxiety disorder treated for a long time with alprazolam. ... - RedNova.com

Acute Akathisia Associated With Quetiapine Use  Jul 6, 2005
53 There have been multiple case reports of akathisia induced by nortriptyline, 53 imipramine, 54 and desipramine. 54 A review by Vandel et al. ... - Psychosomatics (subscription)

Heat has its own set of medical problems  Jul 26, 2005
...channel blockers, water pills), laxatives, diet pills, medicine for bladder incontinence, sedatives and some older antidepressants (amitriptyline, nortriptyline ... - Auburn Citizen

Antidepressants: 1st Choice for Nerve Pain  Jul 19, 2005
...relief. These include medications such as amitriptyline, imipramine, clomipramine, desipramine, and nortriptyline. Anticonvulsant ... - FOX News

Easing The Pain  Jul 18, 2005
Worried about taking too much over-the-counter medication, however, she turned to a neurologist who prescribed nortriptyline, an antidepressant, to treat the ... - New York Sun (subscription) <**results**>

Acute Akathisia Associated With Quetiapine Use  Jul 6, 2005
53 There have been multiple case reports of akathisia induced by nortriptyline, 53 imipramine, 54 and desipramine. 54 A review by Vandel et al. ... - Psychosomatics (subscription)

Pharmac denies attack over critical articles  Jun 28, 2005
Dr Moodie said that to help people stop smoking, Pharmac already funded nicotine patches and gum, and nortriptyline, a drug with similar effectiveness to ... - New Zealand Herald

Improving the Rates of Quitting Smoking for Veterans With ...  Jun 30, 2005
This possibility is supported by evidence showing that sertraline reduces nicotine withdrawal symptoms (53) and that nortriptyline alleviates postcessation ... - Am J Psychiatry (subscription)

Advances in Pharmacogenomics Reduce Side Effects and Save Lives  Jul 5, 2005
...be randomly assigned to one of two antidepressant treatments (the SSRI escitalopram [Lexapro] or the tricyclic antidepressant nortriptyline [Pamelor, Aventyl ... - Psychiatric Times

A continuing headache  Jul 2, 2005
Worried about taking too much over-the-counter medication, she turned to a neurologist, who prescribed nortriptyline, an antidepressant, to treat the pain ... - Malaysia Star

Symptoms of Late-Life Depression Frequency and Change During ...  Jun 14, 2005
In that study the association of individual symptom change and response was presented for 21 patients treated with nortriptyline. ... - Am J Geriatric Psychiatry (subscription)

Steady-state serum concentrations of tricyclic antidepressants are reported to fluctuate significantly when cimetidine is either added or deleted from the drug regimen. Serious anticholinergic symptoms (severe dry mouth, urinary retention, blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressants when cimetidine is added to the drug regimen. In addition, higher-than expected steady-state serum concentrations of tricyclic antidepressants have been observed when therapy is initiated in patients already taking cimetidine.

In well-controlled patients undergoing concurrent therapy with cimetidine, a decrease in the steady-state serum concentrations of tricyclic antidepressants may occur when cime-tidine therapy is discontinued. The therapeutic efficacy of tricyclic antidepressants may be compromised in these patients when cimetidine is discontinued. Several of the tricyclic antidepressants have been cited in these reports.

There have been greater than 2-fold increases in previously stable plasma levels of other antidepressants, including nortriptyline, when fluoxetine hydrochloride has been administered in combination with these agents. Fluoxetine and its active metabolite, norfluoxe-tine, have long half-lives (4 to 16 days for norfluoxetine), that may affect strategies during conversion from one drug to the other.

Administration of reserpine during therapy with a tricyclic antidepressant has been shown to produce a ìstimulatingî effect in some depressed patients. Close supervision and careful adjustment of the dosage are required when nortriptyline hydrochloride is used with other anticholinergic drugs or sympathomimetic drugs.

The patient should be informed that the response to alcohol may be exaggerated.

Drugs Metabolized by P450IID6 óA subset (3% to 10%) of the population has reduced activity of certain drug metabolizing enzymes such as the cytochrome P450 isoenzyme P450IID6. Such individuals are referred to as ìpoor metabolizersî of drugs such as debrisoquin, dextromethorphan, and the tricyclic antidepressants. These individuals may have higher than expected plasma concentrations of tricyclic antidepressants when given usual doses. In addition, certain drugs that are metabolized by this isoenzyme, including many antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, and others), may inhibit the activity of this isoenzyme, and thus may make normal metab-olizers resemble poor metabolizers with regard to concomitant therapy with other drugs metabolized by this enzyme system, leading to drug interactions.

Concomitant use of tricyclic antidepressants with other drugs metabolized by cytochrome P450IID6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Therefore, co-administration of tricyclic antidepressants with other drugs that are metabolized by this isoenzyme, including other antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (eg, propafenone, flecainide, and encainide), or that inhibit this enzyme (eg, quinidine), should be approached with caution.