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Nitrofurazone
drug data and news
Nitrofurazone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Nitrofurazone | ||
| Brand Names/Synonyms | Actin-N; Aldomycin; Alfucin; Amifur; Babrocid; Becafurazone; Biofuracina; Biofurea; Chemofuran; Chixin; Cocafurin; Coxistat; Dermofural; Dymazone; Dynazone; Eldezol; Eldezol F-6; Fedacin; Flavazone; Fracine; Furacilin; Furacillin; Furacin; Furacin Soluble Dressing; Furacin Topical Cream; Furacin Topical Solution; Furacin-E; Furacin-Hc; Furacine; Furacinetten; Furacoccid; Furacort; Furacycline; Furaderm; Furagent; Furalcyn; Furaldon; Furalone; Furametral; Furan-Ofteno; Furaplast; Furaseptyl; Furaskin; Furatsilin; Furaziline; Furazin; Furazina; Furazol W; Furazone; Furazyme; Furesol; Furfurin; Furosem; Fuvacillin; Hemofuran; Ibiofural; Mammex; Mastofuran; Monafuracin; Monafuracis; Monofuracin; NF; NF-7; NFS; NFZ; NSC-2100; Nefco; Nfz Mix; Nifucin; Nifurid; Nifuzon; Nitrofural; Nitrofuraldehyde Semicarbazone; Nitrofuran; Nitrofurane; Nitrofurazan; Nitrofurazone; Nitrofurol; Nitrozone; Otofural; Otofuran; Sanfuran; Spray-Dermis; Spray-Foral; U-6421; Usaf Ea-4; Vabrocid; Vadrocid; Veterinary Nitrofurazone; Yatrocin | ||
| Indication | For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Nitrofurazone is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria. | ||
| Mechanism Of Action | The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase. | ||
| Nitrofurazone News (When available) |
EU rapid alert finds PSP toxins in live mussels from Spain Feb 7, 2006 | ||
| Dosage Forms | OINTMENT | ||
| Drug_Category | Trypanocidal Agents; Anti-Infectives | ||
| Absorption | Well absorbed. | ||
| Interactions | Not Available | ||
| Toxicity | Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated. | ||
| Organisms Affected | Gram negative and gram positive bacteria | ||
| Chemical IUPAC Name | 1-amino-N-[(5-nitro-2-furyl)methylideneamino]methanamide | ||
| Chemical Formula | C6H6N4O4 | ||
| Molecular Weight | 198.136 g/mol | ||
| Smiles String | C1=C(OC(=C1)[N+](=O)[O-])C=NNC(=O)N | ||
| Melting Point | 238 °C | ||
| Water Solubility | 210 mg/L (Approximately 50%) | ||
| State | Solid | ||
| LogP/Hphobicity | 0.517 | ||
| Isoelectric Point | 10 | ||
| Biotransformation | Nitrofurans, including nitrofural, undergo metabolic reduction at the nitro group to generate reactive species which can covalently bind to cellular macromolecules (Polnaszek et al., 1984; Kutcher & McCalla, 1984; McCalla 1979; McCalla et al., 1975). | ||
| Half Life | 5 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Nitrofurazone.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00050 | ||
| CAS Registry Number | 59-87-0 | ||
| KEGG Compound ID | C08042 | ||
| PubChem ID | SID:10242 | ||
| PharmGKB ID | PA450642 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 575011 |
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