Nifedipine drug data and news

Nifedipine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Nifedipine
Brand Names/Synonyms Adalat; Adalat 10; Adalat 20; Adalat 5; Adalat Cc; Adalat Cr; Adalat Crono; Adalat Ft; Adalat Gits; Adalat Gits 30; Adalat La; Adalat Lp; Adalat Oros; Adalat Pa; Adalat Retard; Adalate; Adapine; Adapress; Alat; Aldipin; Alfadal; Alonix; Alonix S; Alpha-Nifedipine Retard; Angipec; Anifed; Anpine; Apo-Nifed; Aprical; BAY 1040; Bay a 1040; Bay-a 1040; Bonacid; CCRIS 6074; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardilate; Cardionorm; Chronadalate; Chronadalate Lp; Citilat; Coracten; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dilcor; Dipinkor; Duranifin; Ecodipi; Ecodipin; Ecodipin E; Fedcor; Fedcor Retard; Fenamon; Fenamon Sr; Fenihidin; Fenihidine; Glopir; Hadipin; Hexadilat; Introcar; Kordafen; Macorel; Megalat; Myogard; N1fedilat; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifedicor; Nifedin; Nifedine; Nifedipine; Nifedipine Retard; Nifedipres; Nifedirex Lp; Nifelan; Nifelat; Nifelat Q; Nifelate; Nifensar Xl; Nificard; Nifidine; Nifipen; Niphedipine; Orix; Oxcord; Pidilat; Procardia; Procardia Xl; Sepamit; Tibricol; Zenusin
Indication For the management of vasospastic angina, chronic stable angina and hypertension
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Description Not Available
Pharmacology Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.
Mechanism Of Action Nifedipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Nifedipine News
(When available)

Industry report  Feb 6, 2006
...to control cholesterol, as well as what it cost to buy a five-pack of Lipitor, Altace for high blood pressure, Celebrex for joint pain, Nifedipine for chest ... - Detroit Free Press,

Medicare Price Hike  Feb 16, 2006
That includes the cost of premiums and deductibles. Consumers Union looked at prices for five drugs: Lipitor, Celebrex, Altace, Nifedipine and Zoloft. ... - Syracuse Post Standard,

Medicare Rx survey: Some plans raise prices  Feb 5, 2006
...cholesterol drug Lipitor, as well as what it cost to buy a five-pack of Lipitor; Altace for high blood pressure; Celebrex for joint pain; Nifedipine for chest ... - Arizona Daily Star,

Use Of A Microsponge in Drug Delivery Systems  Feb 6, 2006
References: A. Barkai, YV Pathak, S. Benita, Polyacrylate (Eudragit retard) microspheres for oral controlled release of nifedipine. I ... - Pharmaceutical Processing,

Industry report  Feb 6, 2006
...to control cholesterol, as well as what it cost to buy a five-pack of Lipitor, Altace for high blood pressure, Celebrex for joint pain, Nifedipine for chest ... - Detroit Free Press,

Medicare Rx survey: Some plans raise prices  Feb 5, 2006
...cholesterol drug Lipitor, as well as what it cost to buy a five-pack of Lipitor; Altace for high blood pressure; Celebrex for joint pain; Nifedipine for chest ... - Arizona Daily Star,

Use Of A Microsponge in Drug Delivery Systems  Feb 6, 2006
References: A. Barkai, YV Pathak, S. Benita, Polyacrylate (Eudragit retard) microspheres for oral controlled release of nifedipine. I ... - Pharmaceutical Processing,

EMEA - Committee For Medicinal Products For Human Use - 23-26 ...  Jan 29, 2006
The Committee concluded a referral procedure for Nifedipine Pharmamatch retard 30 and 60 mg (nifedipine), from Pharmamatch BV, with a recommendation to grant a ... - Medical News Today (press release),

The pain of panic attacks  Jan 17, 2006
I was prescribed low-level anti-depressants, drugs to control acid production in my stomach and Nifedipine - which alleviates angina symptoms. ... - Independent,

Boca drug firm gets FDA approval for pill  Nov 30, 2005
United States. The Food and Drug Administration approved Osmotica's nifedipine last week after more than a year of review. The drug ... - Palm Beach Post,

Secondary Mania in Older Adults  Nov 13, 2005
...episode. Her usual medications included extended-release nifedipine (60 mg/day), ticlopidine (250 mg tid), and benazepril (20 mg/day). ... - Am J Psychiatry (subscription)

Drinking alcohol isn't right for everyone  Nov 30, 2005
...practical. Doctors sometimes prescribe blood pressure medicines like prazosin or nifedipine. Pentoxifylline may also improve circulation. ... - Daily Press,

Vasodilators Don't Delay Need for Aortic Valve Replacement  Sep 29, 2005
...function for a mean of seven years, and found that the rate of valve replacement was similar among patients who took either nifedipine, Vasotec (enalapril ... - MedPage Today,

Artery-Opening Drugs Don't Help Valve Problem  Sep 28, 2005
But a study of 95 people with severe aortic regurgitation found that two widely used vasodilators, nifedipine and enalapril, did nothing of the sort. ... - ABC News

Long-Term Vasodilator Therapy in Patients with Severe Aortic ...  Sep 30, 2005
We randomly assigned 95 patients with asymptomatic severe aortic regurgitation and normal left ventricular function to receive open-label nifedipine (20 mg ... - New England Journal of Medicine (subscription),

Post-carotid endarterectomy cerebral hyperperfusion syndrome  Oct 3, 2005
...occluded. One dose of nifedipine (5 mg sublingual) was administered for control of postoperative hypertension in the recovery area. ... - Journal of the Royal Society of Medicine

New Research: Sticky Liquids Could Help Treat Gut Problems  Sep 26, 2005
The next step assessed whether adding nifedipine and isosorbide dinitrate to the emulsion affected the adhesion, and also whether the drugs were able to ... - PR Newswire UK (press release),

Why should I take a vitamin for my health?  Sep 20, 2005
...chemotherapy; birth control pills (it may reduce their effectiveness); the blood pressure and heart disease medications nifedipine and diltiazem; Coumadin, a ... - MSNBC

Strategies to Prevent Type 2 Diabetes  Aug 12, 2005
INSIGHT)15 showed that, after almost 5 years, 5.4% of the non-diabetic, hypertensive patients randomized to the nifedipine gastrointestinal transport system ... - RedNova.com,

Shilpa Medicare secures WHO, GMP Certification for 14 API`s  Aug 11, 2005
The products are Ambroxol HCL, Buflomedil HCL, Lamivudine, Nifedipine, Sildenafil Citrate, Ticlopidine, Bicalutamide, Cisplatin, Carboplatin, Docetaxel ... - Myiris.com,

Proprietary Chinese medicine recalled  Aug 5, 2005
Five of the six ingredients - morphine, codeine, theophylline, diclofenac and nifedipine - are prescription-only drugs and should be used only under medical ... - News.gov.hk <**results**>

FDA Review of BiDil Shows Genes Matter  Jun 15, 2005
Among the report's findings: * A study of the cardiovascular drug Nifedipine found blood levels of the drug for Mexicans was three times higher than for the US ... - Yahoo News (press release)

The Treatment of Bipolar Disorder – Medications for Mania  Jun 8, 2005
This class of drugs (of which Verapamil, Diltiazem, Nifedipine and Nimodipine are examples) is only used to a very minor degree in managing the symptoms of ... - bipolar.about.com

FDA Review of BiDil Shows Genes Matter  Jun 15, 2005
Among the report's findings: * A study of the cardiovascular drug Nifedipine found blood levels of the drug for Mexicans was three times higher than for the US ... - Yahoo News (press release)

The Contraction of Smooth Muscle Cells of Intrapulmonary ...  May 31, 2005
The 5-HT–induced Ca 2+ oscillations and contractions occurred in the absence of extracellular Ca 2+ and were resistant to Ni 2+ and nifedipine but were ... - Journal of General Physiology

The Frequency of Calcium Oscillations Induced by 5-HT, ACH, and ...  May 31, 2005
KCl-induced responses were resistant to neurotransmitter blockers but were abolished by Ni 2+ or nifedipine and the absence of extracellular Ca 2+ . Caffeine ... - Journal of General Physiology

The Treatment of Bipolar Disorder – Medications for Mania  Apr 14, 2005
This class of drugs (of which Verapamil, Diltiazem, Nifedipine and Nimodipine are examples) is only used to a very minor degree in managing the symptoms of ... - bipolar.about.com

Mercury is not a concern in fish oils  Apr 14, 2005
Mercury appears to accumulate more in fish meat than in fish oils. Q: I take nifedipine, a calcium channel blocker, for high blood pressure. ... - SunHerald.com

Extended release has advantages  Apr 18, 2005
BY RICHARD HARKNESS. Question: I take nifedipine, a calcium channel blocker, for high blood pressure. My blood pressure usually is ... - Detroit Free Press

Base Camp Ho!  Mar 31, 2005
...from both HACE and HAPE and the staff quickly got to work treating her with oxygen, simulated descent (Gamow bag,) nifedipine, acetazolamide, dexamethasone ... - Mounteverest

Reminder: Keep medicines away from children  Apr 5, 2005
Special caution is needed with antipsychotics (chlorpromazine, thioridazine), calcium channel blockers (nifedipine, verapamil), opioids (methadone, morphine ... - Staten Island Advance,

ACTION trial : addition of Nifedipine GITS to conventional ...  Mar 7, 2005
Calcium antagonists such as Nifedipine are used to relieve the symptoms of angina, but there have been doubts about their long-term safety. ... - Xagena.it,

Signal-Transduction Pathways that Regulate Smooth Muscle Function ...  Mar 11, 2005
Interestingly, these contractions required extracellular Ca 2+ and were blocked by the L-type Ca 2+ channel blocker nifedipine. ... - AJP-Gastrointestinal & Liver Physiology (subscription)

Management of Hypertension in Older Persons  Feb 21, 2005
...the metabolism of cyclosporine (Sandimmune) in transplant patients leading to cyclosporine toxicity.22,23 The dihydropyridines, especially nifedipine (Adalat CC ... - RedNova.com,

Dosage Forms CAPSULE; TABLET; TABLET (EXTENDED-RELEASE)
Drug_Category Tocolytic Agents; Vasodilator Agents; Calcium Channel Blockers; Dihydropyridines; ATC:C08CA05
Absorption rapidly and fully absorbed
Interactions Interactions for Nifedipine:

Beta-adrenergic Blocking Agents: Experience in over 1400 patients in a non-comparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension or exacerbation of angina.

Long Acting Nitrates: Nifedipine may be safely co-administered with nitrates, but there have been no controlled studies to evaluate the antianginal effectiveness of this combination.

Digitalis: Immediate Release Capsules: Since there have been isolated reports of patients with elevated digoxin levels, and there is a possible interaction between digoxin and nifedipine, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization. Extended Release Tablets: Administration of nifedipine with digoxin increased digoxin levels in 9 of 12 normal volunteers. The average increase was 45%. Another investigator found no increase in digoxin levels in 13 patients with coronary artery disease. In an uncontrolled study of over 200 patients with congestive heart failure during which digoxin blood levels were not measured, digitalis toxicity was not observed. Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.

Quinidine: Immediate Release Capsules: There have been rare reports of an interaction between quinidine and nifedipine (with a decreased plasma level of quinidine).

Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered. However, the relationship to nifedipine therapy is uncertain.

Cimetidine: A study in 6 healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%) after a 1 week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day. Ranitidine produced smaller, non-significant increases. The effect may be mediated by the known inhibition of cimetidine on hepatic cytochrome P-450, the enzyme system probably responsible for the first-pass metabolism of nifedipine. If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.

Toxicity Dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, weakness; LD50=494 mg/kg(orally in mice); LD50=1022 mg/kg(orally in rats)
Organisms Affected Humans and other mammals
Chemical IUPAC Name dimethyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Chemical Formula C17H18N2O6
Molecular Weight 346.335 g/mol
Smiles String CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Melting Point 172 - 174 °C
Water Solubility Insoluble
State Solid
LogP/Hphobicity 2.343
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 2 hours
Protein Binding [%] 92-98%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Nifedipine.html
http://www.rxlist.com/cgi/generic2/nifedip.htm
Drug Type Approved Drug
Accession No APRD00590
CAS Registry Number 21829-25-4
KEGG Compound ID C07266
PubChem ID SID:172894
PharmGKB ID PA450631
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2235898

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