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Nicergoline
drug data and news
Nicergoline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Nicergoline
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| Brand Names/Synonyms |
FI 6714; MNE; Nargoline; Nicergolin [German]; Nicergolina [Dcit]; Nicergoline; Nicergoline [Usan:Ban:Inn:Jan]; Nicergolinum [Inn-Latin]; Nicotergoline; Nimergoline; Nimergoline Base; Sermion; Vasospan |
| Indication |
Used to treat senile dementia;Migraines of vascular origin;Transient ischemia;Platelet hyper-aggregability;Macular degeneration |
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Description |
Not Available |
| Pharmacology |
Nicergoline is a potent vasodilator (improving brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation. |
| Mechanism Of Action |
Nicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergoline is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter. |
Nicergoline News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Nootropic Agents; Vasodilator Agents; ATC:C04AE02 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Not Available |
| Chemical Formula |
C24H26BrN3O3 |
| Molecular Weight |
484.386 g/mol |
| Smiles String |
CN1CC(CC2(C1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
Not Available |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00617 |
| CAS Registry Number |
27848-84-6 |
| KEGG Compound ID |
C12720 |
| PubChem ID |
SID:175827 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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