Naltrexone drug data and news

Naltrexone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Naltrexone
Brand Names/Synonyms CCRIS 3506; Celupan; HSDB 6750; N-Cyclopropylmethylnoroxymorphone; Naltrexona [Inn-Spanish]; Naltrexone; Naltrexone Hcl; Naltrexone [Usan:Ban:Inn]; Naltrexonum [Inn-Latin]; Revia; UM-792; Vivitrex
Indication For treatment of opioid type drug dependence.
Sponsored links
Description Not Available
Pharmacology Naltrexone, a pure opioid antagonist, is a synthetic congener of oxymorphone with no opioid agonist properties. Naltrexone is indicated in the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids. It markedly attenuates or completely blocks, reversibly, the subjective effects of intravenously administered opioids. When co-administered with morphine, on a chronic basis, Naltrexone blocks the physical dependence to morphine, heroin and other opioids. In subjects physically dependent on opioids, Naltrexone will precipitate withdrawal symptomatology.
Mechanism Of Action Naltrexone binds to the opioid mu receptor antagonistically, thereby preventing conventional opiate (heroin, morphine) drugs from binding and inducing opioid neural responses. The mechanism of action of Naltrexone in alcoholism is not understood; however, involvement of the endogenous opioid system is suggested by preclinical data. Naltrexone competitively binds to such receptors and may block the effects of endogenous opioids.
Naltrexone News
(When available)

Amgen drug settlement called close  Mar 4, 2006
...and the hospital's president, Peter Slavin, declined to disclose the size of the lump sum the hospital would receive for helping invent Enbrel, a rheumatoid ... - Los Angeles Daily News,

Enbrel May Help Patients With Refractory Asthma  Feb 15, 2006
LEICESTER, England - Asthma that is refractory to standard treatment with inhaled corticosteroids may respond to Enbrel (etanercept), a drug for rheumatoid ... - MedPage Today,

The Recent Launch of Enbrel and Forecast Launch of Humira in the ...  Feb 14, 2006
However, the recent launch of Enbrel and forecast launch of Humira in this market is expected to push the biologic class above traditional DMARDs by 2010 in ... - Genetic Engineering News,

Health Canada Approves Enbrel (Etanercept) for Psoriasis treatment  Feb 9, 2006
...painful skin lesions have improved prospects for symptom-free remission, following the announcement that Health Canada has approved Enbrel® (etanercept), an ... - DG News

Amgen close to settling with Boston hospital over drug royalties  Mar 3, 2006
...royalties. At issue are Amgen's payments to the Boston hospital for its role in developing Enbrel, a top selling arthritis drug. ... - Eyewitness News,

Cancer drug may double as an arthritis treatment  Mar 3, 2006
...class of rheumatoid arthritis drugs called tumor necrosis factor, or TNF, blockers. Those drugs include Enbrel, Remicade and Humira. - Deseret News,

'An extraordinary impact'  Feb 27, 2006
He prescribed shots of Enbrel to be administered twice a week. ... Since the Enbrel shots began, Crissa has enjoyed marked improvement. ... - Quincy Herald Whig,

Integrity matters, says Amgen CEO  Mar 3, 2006
Appointed in 2000, he successfully purchased Immunex -- maker of the rheumatoid arthritis drug Enbrel -- and poured more than $1 billion into two Enbrel ... - TMCnet

Cancer drug to remedy arthritis  Mar 3, 2006
...tumor necrosis factor, or TNF, blockers. Those drugs include Enbrel, Remicade and Humira. In rheumatoid arthritis, the body's immune ... - Albuquerque Tribune,

Senate passes bill to meet Amgen's water needs  Mar 3, 2006
Amgen Incorporated has said it will soon require 800-thousand gallons of water a day to continue manufacturing Enbrel, a rheumatoid arthritis drug, at its West ... - Eyewitness News,

Severe Arthritis Linked to Increased Cancer Risk  Feb 27, 2006
In fact, researchers suggest that the drugs Enbrel, Remicade, and Humira and other new and old treatments for RA may actually reduce the chances of developing ... - FOX News

Feds OK Cancer Drug For Rheumatoid Arthritis  Mar 1, 2006
...drugs called TNF blockers, the firms said. Those drugs include Enbrel, Remicade and Humira. Rituxan is already the nation's best ... - KETV.com,

Cancer drug receives federal approval for rheumatoid arthritis  Mar 1, 2006
...rheumatoid arthritis drugs called TNF blockers. Those drugs include Enbrel, Remicade and Humira. Rituxan is already the nation's ... - KESQ,

Rituxan OK'd for Rheumatoid Arthritis  Mar 1, 2006
...intended for people who have not improved with treatments called tumor necrosis factor (TNF) antagonists, such medications include Enbrel and Remicade. ... - WebMD

FDA Approves Rituxan for Refractory Rheumatoid Arthritis  Mar 1, 2006
...was indicated for use in combination with methotrexate in patients with moderate-to-severe RA that has been refractory to treatment with Enbrel (etanercept) or ... - MedPage Today,

Cancer Drug Approved for Arthritis Sufferers  Mar 2, 2006
...haven't had success with a class of rheumatoid arthritis drugs called TNF blockers. Those drugs include Enbrel, Remicade and Humira. - WLNS,

Arthritis Blog Archives  Mar 2, 2006
...and symptoms in adult patients who have moderately-to-severely active rheumatoid arthritis and have failed one or more anti-TNF drugs (Enbrel, Remicade, Humira ... - About - News & Issues,

Genentech/Biogen Idec: Rituxan further expands its options  Mar 2, 2006
...prescribed one or two traditional disease-modifying treatments (DMARDs), followed by the more expensive biologics such as Amgen's Enbrel (etanercept) or ... - Pharmaceutical Business Review

Cancer drug OK for type of arthritis; other uses studied  Mar 2, 2006
...work. Those other drugs include a class of RA drugs called tumor necrosis factor blockers, including Enbrel, Remicade and Humira. ... - Akron Beacon Journal,

Reserch Finds Those with Most Severe Form of Rheumatoid Arthritis ...  Feb 28, 2006
Drugs like Enbrel, Remicade, Humira and others may, in fact, reduce the chances of developing lymphoma in high-risk patients because they reduce inflammation. ... - Newsinferno.com,

Old News!  Feb 28, 2006
My wife is on a Rheumatoid Arthritis medication which is a TNF receptor blocker called etanercept, trade name ENBREL, made by AMGEN, a division of Wyeth. ... - Joplin Independent,

European Medicines Agency: Committee for Medicinal Products for ...  Feb 23, 2006
Enbrel (etanercept), from Wyeth Europe Ltd, to include an alternative dosing regimen of 50 mg once weekly, which will allow treatment of ankylosing spondylitis ... - PharmaLive.com (press release),

Cancer Drug OK'd As Arthritis Treatment  Mar 3, 2006
...t work. Those include a class of RA drugs called tumor necrosis factor blockers, including Enbrel, Remicade and Humira. The FDA ... - W*USA 9,

New Use for Cancer Drug OK‘d  Mar 3, 2006
...t work. Those include a class of RA drugs called tumor necrosis factor blockers, including Enbrel, Remicade and Humira. Shares of ... - Herald News Daily,

Amgen to expand east coast facility  Mar 3, 2006
The Immunex deal allowed it to acquire Enbrel, a popular drug used to treat rheumatoid arthritis and psoriasis that it manufactures at a plant in East Greenwich ... - Ventura County Star (subscription),

Wyeth seeks sales boost from biotech  Feb 21, 2006
Wyeth is already well known for its antibody-based rheumatoid arthritis treatment Enbrel and Prevnar, a vaccine to prevent pneumococcal infections, but Robert ... - MSN Money

IMS Health Reports 5.4 Percent Dollar Growth in 2005 US ...  Feb 22, 2006
Contributors to this growth included Aranesp(r), Enbrel(r), and Neulasta(r), all from Amgen, as well as Genentech's RituxanOLE_LINK2OLE_LINK1(r). ... - PharmaLive.com (press release),

IMS Health Reports 5.4 Percent Dollar Growth in 2005 US ...  Feb 22, 2006
Contributors to this growth included Aranesp(R), Enbrel(R), and Neulasta(R), all from Amgen, as well as Genentech's Rituxan(R). ... - Business Wire (press release),

Rheumatoid Arthritis Drug Is Approved  Feb 28, 2006
...will challenge three older biotechnology drugs that work in much the same way and have combined annual sales of more than $6 billion — Enbrel from Amgen ... - New York Times,

Genentech gets FDA OK for Rituxan for arthritis  Feb 28, 2006
...active rheumatoid arthritis who failed to get adequate relief from previous treatments of at least one other medicine such as Amgen Inc.'s Enbrel or Johnson & ... - ABC News

UPDATE 2-Genentech gets FDA OK for Rituxan for arthritis  Feb 28, 2006
...failed to get adequate relief from previous treatments of at least one other medicine such as Amgen Inc.'s(AMGN.O: Quote, Profile, Research) Enbrel or Johnson ... - Reuters

FDA Approves New Rituxan Use  Mar 1, 2006
...approved for patients who showed inadequate response to other tumor necrosis factor (TNF) therapies such as Johnson & Johnson’s Remicade or Amgen’s Enbrel. ... - Red Herring,

Amgen plans expansion  Mar 1, 2006
About 1,300 workers are employed by Amgen at its Greenwich plants, which are used to produce its rheumatoid arthritis drug Enbrel, according to Sharer. ... - MarketWatch

Amgen will add jobs in Cambridge, CEO says  Mar 1, 2006
Sharer said. The company recently opened a second factory in Rhode Island to produce its rheumatoid arthritis drug Enbrel. It has ... - Boston Herald,

Cancer Drug Approved for Rheumatoid Arthritis  Mar 1, 2006
...manufacturers said Rituxan should be used by people whose RA hasn't responded to a class of drugs called TNF blockers, which include Enbrel, Remicade, and ... - Forbes

The Best-Selling Drugs In America  Feb 27, 2006
According to IMS Health's data, Pfizer makes 3 of the top 20 drugs in the US Amgen makes four of them, including Aranesp, Epogen, Neulasta and Enbrel. ... - Forbes

Roche poised to exploit new arthritis opportunity  Mar 1, 2006
Injectable anti-TNF drugs include Amgen Inc's (AMGN.O: Quote, Profile, Research) Enbrel, Johnson & Johnson's (JNJ.N: Quote, Profile, Research) Remicade and ... - Reuters

UPDATE 1-UCB files Cimzia drug for US approval in Crohn's  Mar 2, 2006
Johnson & Johnson's (JNJ.N: Quote, Profile, Research) Remicade in the Crohn's market and against Amgen's (AMGN.O: Quote, Profile, Research) Enbrel and Abbott ... - Reuters

'This was amazing'  Feb 9, 2006
Three new drugs are now available in Canada - Raptiva, Amevive and Enbrel - which can be injected and have minimal side-effects. ... - Edmonton Sun,

Roche Drug Approved for Rheumatoid Arthritis  Mar 1, 2006
These drugs block the action of the proteins that trigger inflammation during the body's immune system reaction. Enbrel from Amgen Inc. ... - Smartmoney.com

Genentech gets FDA OK for Rituxan for arthritis  Mar 1, 2006
...treatment for rheumatoid arthritis. The drug w - ) Enbrel or Johnson & Johnson‘s (NYSE: - ) Remicade. Those medicines belong to ... - Brocktown News,

Genentech, Biogen cancer drug approved for new indication  Mar 2, 2006
Rituxan can also be prescribed to patients who have not responded to a class of drugs known as the TNF blockers, such as Enbrel, Remicade and Humira. ... - New Ratings

Cancer drug gets US OK to treat rheumatoid arthritis  Mar 2, 2006
The two companies said Rituxan should be used by patients who haven't had success with a class of rheumatoid arthritis drugs including Enbrel, Remicade and ... - Salem News,

Biotechs take a stronghold on sales  Mar 1, 2006
...related anemia; Epogen, for anemia from chronic kidney disease; Neulasta, a white blood cell booster for chemotherapy patients; and Enbrel, a treatment for ... - Newark Star Ledger,

Today's Business  Mar 2, 2006
...necrosis factor, or TNF, blockers. Those include Enbrel, Remicade and Humira. Omaha, Neb. | Berkshire Hathaway Inc., billionaire ... - Myrtle Beach Sun News,

Wyeth Reports Earnings Results for the 2005 Fourth Quarter and ...  Jan 31, 2006
..."With strong growth from biotechnology products such as Enbrel(R) and our vaccine, Prevnar(R ... ENBREL(R) continued to post strong global revenue growth in 2005. ... - PR Newswire (press release),

FDA clears Rituxan for rheumatoid arthritis  Mar 1, 2006
...have not responded to biologic therapy based on tumour necrosis factor blockers, namely Centocor's Remicade (infliximab), Amgen/Wyeth's Enbrel (etanercept) and ... - Pharma Times (subscription),

Business digest  Mar 2, 2006
Those include a class of RA drugs called tumor necrosis factor blockers, which includes Abbott Laboratories’ Enbrel, Remicade and Humira. ... - Worcester Telegram (subscription),

Dosage Forms TABLET
Drug_Category Anti-craving Agents; Depressants; Alcohol Antagonists; Opiate Antagonists; ATC:N07BB04
Absorption Not Available
Interactions Interactions for Naltrexone:

Studies to evaluate possible interactions between REVIA and drugs other than opiates have not been performed. Consequently, caution is advised if the concomitant administration of REVIA and other drugs is required.

The safety and efficacy of concomitant use of REVIA and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.

Lethargy and somnolence have been reported following doses of REVIA and thioridazine.

Patients taking REVIA may not benefit from opioid containing medicines, such as cough and cold preparations, antidiarrheal preparations, and opioid analgesics. In an emergency situation when opioid analgesia must be administered to a patient receiving REVIA, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged.

Toxicity LD50 = 1450 mg/kg (rat)
Organisms Affected Humans and other mammals
Chemical IUPAC Name Not Available
Chemical Formula C20H23NO4
Molecular Weight 341.401 g/mol
Smiles String C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O
Melting Point 169-170 oC (274-276 oC for hydrochloride salt)
Water Solubility 100 mg/mL
State Solid
LogP/Hphobicity 1.692 (1.92 by expt)
Isoelectric Point Not Available
Biotransformation When administered orally, naltrexone undergoes extensive biotransformation and is metabolized to 6 beta-naltrexol and other minor metabolites.
Half Life 4 hours
Protein Binding [%] 21%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Naltrexone.html
http://www.rxlist.com/cgi/generic2/naltrexone.htm
Drug Type Approved Drug
Accession No APRD00005
CAS Registry Number 16590-41-3
KEGG Compound ID C07253
PubChem ID SID:9462
PharmGKB ID PA450588
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2213826

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