Naloxone drug data and news

Naloxone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Naloxone

Brand Names/Synonyms

En 1530 Base; HSDB 3279; L-Naloxone; N-Allylnoroxymorphone; Nalone; Nalossone [Dcit]; Naloxona [Inn-Spanish]; Naloxone; Naloxone Hcl; Naloxonum [Inn-Latin]; Narcan; Narcanti; Narcon; Narcotic Antagonist;

Indication

Naloxone is indicated for the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol.

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Description

Not Available

Pharmacology

Naloxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; Naloxone does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity.

Mechanism Of Action

While the mechanism of action of Naloxone is not fully understood, the preponderance of evidence suggests that Naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.

Naloxone News
(When available)

Mass. Docs Tout Habit Buster; Drug AIDS Opioid Users Mar 5, 2006
Suboxone, which is manufactured by the British company Reckitt Benckiser Pharmaceuticals Inc., is a combination of buprenorphine and naloxone. ... - International News Service,

Ultrasonic Rat Vocalizations During the Formalin Test: A Measure ... Feb 21, 2006
...to establish the formalin concentration to induce USV and the relationship of USV emission with motor behaviors and the effects of morphine and naloxone on USV ... - Anesthesia & Analgesia (subscription),

Public Citizen Petitions FDA to Ban Darvon Products Feb 28, 2006
These events are not reversed by opiate antagonists such as naloxone and up to 76% of deaths from propoxyphene overdose are a result of cardiac toxicity.[22 ... - PharmaLive.com (press release),

Heroin Detoxification Feb 22, 2006
...the introduction of either ultrarapid opiate detoxification (using general anesthesia along with an opioid antagonist, such as intravenous naloxone) or rapid ... - Journal of American Medical Association (subscription),

Javelin Presents Intranasal Morphine Safety and Efficacy Data at ... Feb 23, 2006
Oxygen desaturation was mostly mild-to-moderate and was resolved spontaneously or with nasal oxygen, but in no instance required intervention with naloxone. ... - PR Newswire (press release),

Detoxification and Treating Opioid Dependence Feb 21, 2006
Major cardiopulmonary complications are rare but recognized consequences of administering opioid antagonists, including naloxone. ... - Journal of American Medical Association (subscription),

Heroin ODs in overdrive Feb 6, 2006
All overdosed in a four-hour stretch but were revived with naloxone, a liquid that reverses the fatal effects of opiate drugs, said Scott, who studies ... - Chicago Tribune,

NIDA ADDICTION RESEARCH NEWS Feb 1, 2006
Results of a study performed in mice show that naloxone was able to block activation of the brain's molecular pathways that reinforce smoking behaviors and ... - Nieuwsbank (persbericht),

CEAQ.OB Announces Signing of Letter of Intent Feb 14, 2006
Aoxing has developed a patented manufacturing process for a variety of generic analgesic drugs including oxycodone, pholcodine, naloxone, and tilidine. ... - Market Wire (press release)

National Survey Finds Nearly Half of Public Unaware Prescription ... Feb 1, 2006
Painkiller/Heroin Addiction and Treatment, a separate, parallel survey of 57 people being treated with Suboxone(R) (buprenorphine HCl/naloxone HCl dihydrate) C ... - PR Newswire (press release),

Dosage Forms

LIQUID

Drug_Category

Antinarcotic Agents; Depressants; Opiate Antagonists; ATC:V03AB15

Absorption

Not Available

Interactions

Interactions for Naloxone:

No information provided.

Toxicity

Not Available

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

Not Available

Chemical Formula

C19H21NO4

Molecular Weight

327.374 g/mol

Smiles String

C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O

Melting Point

200 - 205 °C

Water Solubility

Soluble in water.

State

Solid

LogP/Hphobicity

1.464

Isoelectric Point

Not Available

Biotransformation

Hepatic.

Half Life

30-81 minutes

Protein Binding [%]

Not Available

RxList Link

RXlist

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Drug Reference

http://www.rxlist.com/cgi/generic3/naloxone.htm

Drug Type

Approved Drug

Accession No

APRD00025

CAS Registry Number

465-65-6

KEGG Compound ID

C07252

PubChem ID

SID:9461

PharmGKB ID

PA450586

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

2148706