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Muromonab
drug data and news
Muromonab drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Muromonab
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| Brand Names/Synonyms |
Orthoclone OKT3; antiCD3; Orthoclone OKT3 (Ortho Biotech) |
| Indication |
For treatment of organ transplant recipients, prevention of organ rejection |
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Description |
Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a). |
| Pharmacology |
Used in organ transplant prophylaxis, Muromonab or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD- 3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients. |
| Mechanism Of Action |
Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity. |
Muromonab News
(When available) |
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| Dosage Forms |
SOLUTION |
| Drug_Category |
Immunosuppressants; Immunomodulatory Agents; unclassified therapeutic agents (92:00.00) |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Murine anti-CD3 antibody |
| Chemical Formula |
C6460H9946N1720O2043S56 >1SY6:L OKT3 Light Chain 1 >1SY6:H OKT3 Heavy Chain 2 >1SY6:L OKT3 Light Chain 2 |
| Molecular Weight |
146189.7 |
| Smiles String |
Not Available |
| Melting Point |
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.513 |
| Isoelectric Point |
8.31 |
| Biotransformation |
Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production |
| Half Life |
0.8 hours (mammalian reticulocytes, in vitro) |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00005 |
| CAS Registry Number |
Not Available |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2015978
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