Mupirocin drug data and news

Mupirocin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Mupirocin

Brand Names/Synonyms

Bactoderm; Bactroban; Bactroban Nasal; Centany; MRC; Mupirocin; Mupirocine; PSEUDOMONIC ACID; Turixin

Indication

For the treatment of staphylococci nasal carriers

Sponsored links

Description

Not Available

Pharmacology

Mupirocin, an antibiotic produced from Pseudomonas fluorescens, is structurally unrelated to any other topical or systemic antibiotics. Mupirocin is used to treat infection caused by Staphylococcus aureus and beta-hemolytic streptococci including Streptococcus pyogenes. This antibiotic has little, if any, potential for cross-resistance with other antibiotics.

Mechanism Of Action

Mupirocin reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA, resulting in the inhibition of bacterial protein and RNA synthesis.

Mupirocin News
(When available)

New treatments subsidised for acne, pain Feb 27, 2006
..."There is a risk that the use of topical antibiotics such as fusidic acid and mupirocin can lead to bacterial resistance, and this can limit the effectiveness ... - Scoop.co.nz (press release),

GlaxoSmithKline's Topical Antibacterial Retapamulin Accepted for ... Feb 14, 2006
...heritage in the development of novel anti-infectives to meet clinical needs, including the topical antibacterial agent Bactroban® (mupirocin) as well as the ... - Yahoo! News (press release)

Retapamulin demonstrates promising activity against pathogens ... Jan 10, 2006
...growth of 90 percent of bacteria tested was lowest for retapamulin, when compared to thirteen other agents tested, including Mupirocin, Amoxicillin/Clavulanic ... - Xagena.it,

Hospital "super super bug" stronger than MRSA 12 Dec 2005
As well as gentamicin, a frontline antibiotic in the treatment of MRSA, the strain is also resistant to mupirocin, fucidin, rifampicin. ... - News-Medical.net,

Fougera Introduces the First Unit-of-Use Delivery System for ... Dec 1, 2005
Today, specialty pharmaceutical manufacturer Fougera, a division of ALTANA Inc announced that it is first-to- market with FDA- approved Mupirocin Ointment USP 2 ... - PR Newswire (press release),

Superbug worse than MRSA claims 11 hospital victims Dec 9, 2005
Coventry hospital. This strain of MRSA is also resistant to other frontline antibiotics mupirocin, fuicidin and rifampicin. The ... - ic Birmingham.co.uk,

(PRN) - ESCO to Post Updated Presentation on Web Site ... [+] Dec 1, 2005
Subsidiary ... [+. PRN) - Fougera Introduces the First Unit-of-Use Delivery System for Mupirocin Ointment USP 2% (Rx) ... [. PRN ... - Bolsamania.com,

Taro Receives Approval For Mupirocin Ointment USP, 2% ANDA Sep 23, 2005
...has received approval from the US Food and Drug Administration for its Abbreviated New Drug Application for Mupirocin Ointment USP, 2% ("mupirocin ointment"). ... - PrimeZone (press release),

Taro Gets FDA OK for Generic Bactroban Sep 23, 2005
Taro's Mupirocin ointment is a prescription antibiotic product used for the topical treatment of impetigo, a bacterial skin infection characterized by pus ... - Forbes

Taro gets FDA OK for generic impetigo ointment Sep 23, 2005
The drugmaker said it received approval from the Food and Drug Administration to market its product, known generically as mupirocin ointment. ... - Reuters

Helix BioMedix Invited to Present at SRI's Peptides and ... Oct 3, 2005
HB50 is a broad spectrum topical anti-infective that effectively prevents S. aureus wound infection including infections caused by mupirocin resistant MRSA. ... - Yahoo! News (press release)

Burbs: IBM unveils online job site Sep 24, 2005
...said yesterday that it has received approval from the US Food and Drug Administration on its application for Mupirocin ointment. ... - The Journal News.com,

Honey used as an antibiotic Aug 25, 2005
Kidney specialist David Johnson said honey also had an advantage over the commonly used antibiotic ointment, mupirocin, in that hospital "superbugs" such as ... - NEWS.com.au,

Intertrigo and Common Secondary Skin Infections Aug 30, 2005
...intertrigo patients (adults and children) with GABHS may be a concomitant or independent regimen of topical therapies (eg, mupirocin [Bactroban], erythromycin ... - American Family Physician <**results**>

Picking nose likely resulted in infection ASK DR. H MITCHELL HECHT Jul 5, 2005
The good news is that Mupirocin (Bactroban) nasal ointment applied three times a day for a period of 5-7 days should that care of your infection. ... - Wilkes Barre Times-Leader,

Foamix Selected to Present at the Bio Business Forum at Bio ... Jun 8, 2005
Wednesday, June 22, from 0900-1200 Innovative Antifungal Terbinafine Foam Pharmaceuticals, Wednesday, June 22, from 0900-1200 Novel Mupirocin Foam for Skin ... - PR Newswire (press release)

Local news briefs Apr 10, 2005
...as many complications. The hospital reduced infections by changing the way it administers a drug called mupirocin. The "Spirt of ... - Cincinnati Enquirer,

Impetigo : Skin disorder causing skin problems Feb 23, 2005
Antibiotics, such as cephalexin, dicloxacillin, or mupirocin, may be taken as pills or used as an ointment on the skin lesions. ... - Express Newsline,

Dosage Forms

Topical ointment, nasal spray

Drug_Category

Anti-bacterial Agents; Antibiotics; ATC:D06AX09; ATC:R01AX06

Absorption

no measurable systemic absorption

Interactions

Interactions for Mupirocin:

No information provided.

Toxicity

Not Available

Organisms Affected

Enteric bacteria and other eubacteria

Chemical IUPAC Name

13-[3,4-dihydroxy-5-[[3-(2-hydroxy-1-methyl-propyl)oxiran-2-yl]methyl]tetrahydropyran-2-yl]-12-methyl-10-oxo-tridec-11-enoicacid

Chemical Formula

C26H44O8

Molecular Weight

484.623 g/mol

Smiles String

CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)CCCCCCCCC(=O)O)C)C(C)O

Melting Point

77-78°C

Water Solubility

mg/mL

State

Solid

LogP/Hphobicity

2.611

Isoelectric Point

Not Available

Biotransformation

Hepatic

Half Life

20 to 40 minutes

Protein Binding [%]

97%

RxList Link

RXlist

Sponsored links

Drug Reference

http://www.drugs.com/cons/Mupirocin.html
http://www.rxlist.com/cgi/generic/mupi.htm

Drug Type

Approved Drug

Accession No

APRD00162

CAS Registry Number

12650-69-0

KEGG Compound ID

Not Available

PubChem ID

SID:645318

PharmGKB ID

Not Available

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

2239757