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Moxifloxacin
drug data and news
Moxifloxacin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Moxifloxacin | ||
| Brand Names/Synonyms | Avelox; Avelox I.V.; CHEMBANK1636; Moxifloxacin; Moxifloxacin Hcl; Moxifloxacin Hydrochloride; Vigamox | ||
| Indication | For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species* Acinetobacter lwoffii* Micrococcus luteus* Haemophilus influenzae Staphylococcus aureus Haemophilus parainfluenzae* Staphylococcus epidermidis Staphylococcus haemolyticus Staphylococcus hominis Chlamydia trachomatis Staphylococcus warneri* Streptococcus pneumoniae | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Moxifloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. | ||
| Mechanism Of Action | The bactericidal action of Moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. | ||
| Moxifloxacin News (When available) |
European govts give $14 mln to find new TB drugs 07 Mar 2006 Antibiotic Tequin risky to diabetes patients Mar 5, 2006 Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults Mar 1, 2006 A Reduction In Tuberculosis Incidence, Prevalence And Death Rate ... Mar 4, 2006 Tequin Linked to High Risk of Dangerous Glucose Changes Mar 1, 2006 Clostridium difficile: Old Scourge Becomes Far Worse Feb 9, 2006 CAPRIE study: Moxifloxacin more effective in elders pneumonia Jan 24, 2006 SA study cites drug's role Jan 25, 2006 Newer Antibiotic more Effective at Treating Pneumonia in Senior ... Jan 24, 2006 Head-To-Head Study Shows More Elderly Patients With Community ... Jan 24, 2006 The University of Texas Study: Newer Antibiotic More Effective at ... Jan 24, 2006 Researchers find improved treatment for pneumonia in elderly Jan 24, 2006 Newer antibiotic battles pneumonia better Jan 24, 2006 Bayer Drug Better Than Leading Pneumonia Treatment Jan 28, 2006 Head-To-Head Study Shows More Elderly Patients With Community ... Jan 24, 2006 New combination treatment that could dramatically shorten the ... Jan 10, 2006 (PRN) - Emerging Market for Omega-3 Fatty Acids Gains Ground ... ... Jan 24, 2006 New Drug Combination May Shorten TB Treatment Jan 17, 2006 E. Coli Defense Mechanism May Provide Key to Disrupting Bacteria ... Jan 16, 2006 Shionogi Launches New Quinolone Antibacterial "Avelox(R) Tablet ... Dec 9, 2005 Shionogi Launches New Quinolone Antibacterial “Avelox Tablet ... Dec 9, 2005 Shionogi Launches New Quinolone Antibacterial Avelox(R) Tablet ... Dec 9, 2005 FDA approves AVELOX (moxifloxacin HCl) for treatment of ... Nov 29, 2005 FDA Approves New Indication for Avelox (moxifloxacin HCl) for ... Nov 30, 2005 TB treatment and diagnostics pipeline: once empty, suddenly offers ... Dec 2, 2005 FDA Approvals: Avelox, Avandaryl, Trileptal Dec 1, 2005 New Epidemic Strain of C. difficile Seen Emerging in North America Dec 2, 2005 FDA has approved new indication for Avelox: treatment of ... Dec 6, 2005 Deadly Bacterial Illness May Be Spreading Dec 1, 2005 New intestinal bug emerging in North America Dec 2, 2005 Euronext Brussels) - Bayer : Avelox ® Approved in US to Treat ... Nov 30, 2005 (PRN) - Armor Holdings, Inc. Receives $20.2 Million Order for ... Nov 30, 2005 Deadly bacterial illness spreading Dec 2, 2005 Deadly Bacterial Illness May Be Spreading Dec 2, 2005 Avelox approved for stomach problems Dec 1, 2005 CDC: Deadly bacterial illness appears to be spreading Dec 1, 2005 When public health outweighs profits Nov 10, 2005 Big firms join drug program Nov 15, 2005 Experts promote earlier use of more potent antibiotics for ... Sep 20, 2005 Legionnaires' disease - Legionellosis Oct 6, 2005 Many meds don't mix with the sun Sep 21, 2005 Ortho-McNeil: less is more with Levaquin Aug 9, 2005 FDA Approvals: Rozerem, Synera, Avelox IV Jul 28, 2005 International Approvals: Avalox IV, Pegasys, Influvac Jul 25, 2005 Avelox® IV Approved in Europe to Treat Complicated Skin and Skin ... Jul 30, 2005 FDA Bans Poultry Antibiotic to Prevent Resistant Human Infections Jul 29, 2005 Avelox IV Approved in Europe to Treat Complicated Skin and Skin ... Jul 18, 2005 | ||
| Dosage Forms | SOLUTION; TABLET | ||
| Drug_Category | Anti-bacterial Agents; Quinolones; ATC:J01MA14 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Moxifloxacin: Drug-drug interaction studies have not been conducted with VIGAMOX™ solution. In vitro studies indicate that moxifloxacin does not inhibit CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2 indicating that moxifloxacin is unlikely to alter the pharmacokinetics of drugs metabolized by these cytochrome P450 isozymes. | ||
| Toxicity | Convulsions, decreased activity, diarrhea, sleepiness, tremors, vomiting | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 1-cyclopropyl-7-(5,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1H-quinoline-3-carboxylicacid | ||
| Chemical Formula | C21H24FN3O4 | ||
| Molecular Weight | 401.431 g/mol | ||
| Smiles String | COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O | ||
| Melting Point | 238-242 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 2.033 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 13 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Moxifloxacin.html http://www.rxlist.com/cgi/generic3/vigamox.htm http://www.pharmgkb.org/views/index.jsp?objId= | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00281 | ||
| CAS Registry Number | 151096-09-2 | ||
| KEGG Compound ID | C07663 | ||
| PubChem ID | SID:65432 | ||
| PharmGKB ID | PA450555 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2246414 |
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