Minoxidil drug data and news

Minoxidil drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Minoxidil
Brand Names/Synonyms Alopexil; Alostil; Apo-Gain; CHEMBANK82; Gen-Minoxidil; HSDB 6538; KC-125; Loniten; Lonolox; M142; Minodyl; Minossidile; Minossidile [Italian]; Minoxidil; Minoxidil [Usan:Ban:Inn]; Minoxidilum [Inn-Latin]; Minoxigaine; Minoximen; Normoxidil; PDP; Pierminox; Prexidil; Regaine; Rogaine; Rogaine Extra Strength for Men; Rogaine for Men; Rogaine for Women; Theroxidil; Triclosan; Tricoxidil; Trocoxidil
Indication Indicated in the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia.
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Description Not Available
Pharmacology Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Minoxidil is also used topically to treat androgenetic alopecia. Microcirculatory blood flow in animals is enhanced or maintained in all systemic vascular beds. In man, forearm and renal vascular resistance decline; forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved. The predominant site of minoxidil action is arterial. Venodilation does not occur with minoxidil; thus, postural hypotension is unusual with its administration. The antihypertensive activity of minoxidil is due to its sulphate metabolite, minoxidil sulfate.
Mechanism Of Action Minoxidil is thought to promote the survival of human dermal papillary cells (DPCs) or hair cells by activating both extracellular signal-regulated kinase (ERK) and Akt and by preventing cell death by increasing the ratio of BCl-2/Bax. Minoxidil may stimulate the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. Minoxidil, when used as a vasodilator, acts by opening adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells. This vasodilation may also improve the viability of hair cells or hair follicles.
Minoxidil News
(When available)

Hair Loss In Women: More Than Meets The Eye  Mar 3, 2006
Topical minoxidil is one treatment for women with female pattern hair loss, but it must be applied to the scalp twice a day for at least four months before the ... - eMaxHealth.com,

Getting the head straight about hair loss  Feb 28, 2006
The other is minoxidil, a topical solution that helps increase the anagen phase of the hair cycle. ... Minoxidil has also been used with some success for women. ... - Globe and Mail,

Have We Won The Fight Against Hair Loss?  Feb 6, 2006
2. Minoxidil and Propecia are the only FDA approved drugs to treat hair loss. 3. Neither Minoxidil or Propecia is 100% guaranteed to work. ... - DailyIndia.com,

New Hair Loss Treatment for Men Finds Answer to Stronger Hair in ...  Feb 15, 2006
...regimen for men that includes dermatologist-strength retinol for the first time without a prescription, in addition to shampoo, FDA-approved Minoxidil 5%, anti ... - PR Web (press release),

New Hair Loss Treatment for Men Finds Answer to Stronger Hair in ...  Feb 13, 2006
The new hair loss treatment system includes FDA-approved 5% Minoxidil solution, Daily Revitalizing Shampoo, and Anti-DHT Hair Regrowth Booster Tablets in ... - WebWire (press release),

CAUSE OF MUSCLE CRAMPS OFTEN NOT FOUND  Feb 19, 2006
...prescription. It costs around $21 a month. It also comes as the generic minoxidil for $15. Both require a lifelong commitment. Hair ... - Charlotte Sun-Herald,

Alopecia Areata Hair Loss  Feb 13, 2006
However, corticosteroid creams are less effective than injections; they work best when combined with other topical treatments, such as minoxidil. ... - The Open Press (press release)

Have We Won The Fight Against Hair Loss?  Feb 6, 2006
2. Minoxidil and Propecia are the only FDA approved drugs to treat hair loss. 3. Neither Minoxidil or Propecia is 100% guaranteed to work. ... - DailyIndia.com,

The bald truth about Healey's misleading ad  Jan 24, 2006
...were unproven. The only proven element of the treatment was hair growth drug Minoxidil (Gav the Chav's fave, we believe). The Advertising ... - Unison.ie,

Questions and Answers About Alopecia Areata  Jan 23, 2006
...ointments and creams alone are less effective than injections; they work best when combined with other topical treatments, such as minoxidil or anthralin. ... - Community Dispatch (press release)

Connetics Reports Fourth Quarter Revenues of $41.3 Million and EPS ...  Jan 31, 2006
In January 2006, Pfizer received FDA approval for Men's Rogaine(R) (minoxidil, 5%) foam using Connetics' VersaFoam(R) technology. Connetics owns US Patent No. ... - Genetic Engineering News,

From treating blemishes to heart disease, the ins and outs of 'off ...  Jan 30, 2006
...profitable for drug companies. Minoxidil, the hair-loss remedy, for instance, started out as a high blood pressure drug. And Botox, the ... - Charleston Post Courier (subscription),

Umpire raises finger to laser hair ad  Jan 12, 2006
They said the drug used to stimulate growth - Minoxidil - would work by itself anyway, and that continuous treatment was needed, which the advertisements did ... - New Zealand Herald,

AUSTIN AD BANNED  Jan 11, 2006
...or stop its loss were unproven. The only proven element of the treatment was hair growth drug Minoxidil. The ASA also ruled that ... - Mirror.co.uk,

Boca hair loss clinic treating large number of women  Jan 14, 2006
On the non-surgical side, such FDA-approved lotions as Minoxidil are used to add thickness to hair and stimulate growth among hair follicles. ... - Boca Raton News,

Health Tip: Will I Go Bald?  Jan 30, 2006
Treatments to help baldness include medications such as minoxidil, as well as hair transplants, which remove hair from places where it is still growing and ... - Forbes

Spruiking the lush regrowth OK for Warnie, but not in Britain  Jan 11, 2006
...there. They complained it was the drug Minoxidil, used at the same time as the laser, that was the real reason hair came back. The ... - Sydney Morning Herald,

Fighting Baldness, and Now an Olympic Ban  Jan 18, 2006
Had Mr. Lund used Rogaine, whose active ingredient is minoxidil, he would have been home free and potentially with just as much new hair, since that anti ... - New York Times,

Shane Warne ads 'untrue'  Jan 10, 2006
...told the ASA it was not accepted infrared radiation could reverse hair loss — or that it was more effective than the over-the-counter medication Minoxidil. - The Sun,

Humor the best baldness defense  12 Dec 2005
...number of scientific or pseudoscientific attempts to stave off the Grim Reaper, not the least of which are Rogaine, the brand name of minoxidil, and Propecia ... - Fort Wayne Journal Gazette,

Medical cure for male-pattern baldness  Dec 4, 2005
At present, two drugs for the treatment of male pattern baldness, minoxidil and finasteride, are available. The first, minoxidil ... - Manila Bulletin,

Curing male-pattern baldness  Dec 8, 2005
Sure, some men say bald is beautiful. And others can smear on minoxidil (Rogaine), take Propecia pills or get hair transplants. ... - Grand Forks Herald,

`Hair cure of the human' may harm cats  Nov 30, 2005
Topical solutions containing minoxidil (like Rogaine) are used to safely promote hair growth in humans, but pose serious health risks to cats. ... - Fort Wayne News Sentinel,

Science devising new approaches for treating baldness  Dec 3, 2005
...inroads from the front. And others can smear on minoxidil (Rogaine) or take Propecia pills, or get hair transplants. In fact, right ... - Newstarget.com,

Move over Rogaine, hair clones close  Nov 15, 2005
...front. Sure, some men say bald is beautiful. Others smear on minoxidil (Rogaine), take Propecia pills, or get hair transplants. In ... - TheNewsTribune.com (subscription),

A thin line  Nov 21, 2005
The only treatment proven to slow hair loss for women is minoxidil, or Rogaine, and it's possible the product might be more effective for women than for men ... - Daily Breeze,

More on PlanetOut  Nov 17, 2005
...out there? One treatment that has been proven to really make a difference is Minoxidil, which has the brand name Rogaine. It's been ... - PlanetOut,

Scientists Study How to Make a Bald Head Hairy Again  Nov 15, 2005
Sure, some men say bald is beautiful. And others can smear on minoxidil (Rogaine) or take Propecia pills or get hair transplants. ... - The Ledger,

A Pate Worse than Death  Oct 5, 2005
Minoxidil (sold as Rogaine) began life as a blood pressure medication, and finasteride (sold as Propecia) was developed as a prostate drug. ... - Boise Weekly,

Women seek hair-loss remedies, too  Sep 26, 2005
...women.". Rogaine (the brand name of the drug minoxidil) is the only medicine known to slow hair loss in both men and women. Women's ... - Los Angeles Daily News,

Full-On Gorgeous Hair: The Solution Women Have Been Waiting For  Sep 29, 2005
What's the scoop? Regaine(R) for Women Regular Strength contains an active ingredient, minoxidil, which can stimulate hair growth. ... - PR Newswire UK (press release),

Changes in diet can sometimes lead to hair loss  Sep 13, 2005
Minoxidil, the active ingredient in the topical treatment Rogaine, is often recommended for chronic hair loss, although it doesn't work for everyone and has to ... - Pittsburgh Post Gazette,

Alopecia: What you need to know  Sep 13, 2005
...and diarrhoea. Topical Minoxidil solution, marketed as Regaine, can be useful for some patients with mild alopecia areata. It is ... - Daily Mail - UK,

Baldness cure or scam?  Sep 21, 2005
An over-the-counter medication called minoxidil can promote new hair growth in a small percentage of people, but the drug eventually loses its effectiveness ... - Health24.com,

Roundup: Cats And Minoxidil; Olives And Bacteria; Toothbrush ...  Aug 19, 2005
Topical solutions, like Rogaine, that contain the drug Minoxidil have helped many people prevent thinning hair, but Minoxodil can also pose a health risk to ... - NBC 10.com,

Hair treatment poses feline danger  Aug 24, 2005
Here it is. "Topical solutions containing minoxidil, used to promote hair growth in humans, have become increasingly popular in recent years. ... - Casa Grande Valley Newspapers,

Hair loss webchat  Sep 6, 2005
Carol Michaelides: The clinic I practice in rarely uses more than 3% minoxidil on women as all the clinical data shows that it is just as effective at 3 ... - GMTV,

Legitimate remedies for balding are improving  Sep 6, 2005
He recommends a combination therapy of minoxidil (Rogaine) applied to the scalp and the pill finasteride (Propecia), even for men who have transplants. ... - Press-Enterprise (subscription),

GPs warned on hair clinic scripts  Aug 2, 2005
...a letter from a patient who had attended the Institute of Hair Regrowth and Beauty asking him to prescribe two topical medications — minoxidil (Rogaine) and ... - AustralianDoctor.com (subscription)

ASK THE DOCTOR: Drink water to compensate for loss in sweating ...  Jul 22, 2005
I once read your doctor suggest Minoxidil lotion. ... Minoxidil is one of the treatments used for this condition along with other drugs. ... - Peninsula On-line

LaserComb brings hair-loss solutions  Jul 30, 2005
Twice a day for about four years I've been spraying minoxidil on the crown of my head, which is the only place on the skull where the substance works. ... - Press-Enterprise (subscription)

Keep your hair on  Jul 9, 2005
...potions that they claim can cure baldness, when in fact there are really only two treatments that are clinically proven.� These are minoxidil, marketed by ... - The Statesman

If you're hairless, don't be careless  Jul 19, 2005
You’ve gone chrome dome. There are immediate benefits: no more shampoo, detanglers, sprays, minoxidil or fancy boar hairbrushes. The only worry now? ... - Kansas City Star

Aging Is Getting Old  Jul 6, 2005
People smeared various appalling concoctions on their heads to no effect before minoxidil appeared, but though they were ripped off, it was proof that there ... - Tech Central Station

Dosage Forms LIQUID, TABLET
Drug_Category Vasodilator Agents; Antihypertensive Agents; Skin and Mucous Membrane Agents (84:92.00); ATC:C02DC01; ATC:D11AX01
Absorption Minoxidil is at least 90% absorbed from the GI tract in experimental animals and man.
Interactions Interactions for Minoxidil: Interaction with Guanethidine: Although minoxidil does not itself cause orthostatic hypotension, its administration to patients already receiving guanethidine can result in profound orthostatic effects. If at all possible guanethidine should be discontinued well before minoxidil is begun. Where this is not possible, minoxidil therapy should be started in the hospital and the patient should remain institutionalized until severe orthostatic effects are no longer present or the patient has learned to avoid activities that provoke them.
Toxicity Cardiovascular effects associated with hypotension, sudden weight gain, rapid heart beat, faintness or dizziness.
Organisms Affected Humans and other mammals
Chemical IUPAC Name 3-hydroxy-2-imino-6-(1-piperidyl)-3H-pyrimidin-4-amine
Chemical Formula C9H15N5O
Molecular Weight 209.248 g/mol
Smiles String C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
Melting Point 248 °C
Water Solubility 2200 mg/L
State Solid
LogP/Hphobicity 0.762
Isoelectric Point 4.61
Biotransformation Approximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products. Known metabolites exert much less pharmacologic effect than minoxidil itself.
Half Life 4.2 hours
Protein Binding [%] Minoxidil does not bind to plasma proteins.
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Minoxidil.html
http://www.rxlist.com/cgi/generic3/minoxidil.htm
Drug Type Approved Drug
Accession No APRD00086
CAS Registry Number 38304-91-5
KEGG Compound ID C07226
PubChem ID SID:9435
PharmGKB ID PA450521
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2065800

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