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Minocycline
drug data and news
Minocycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Minocycline | ||
| Brand Names/Synonyms | Alti-Minocycline; Apo-Minocycline; Arestin; BRN 3077644; CL 59806; DYNACIN; Dynacin; Gen-Minocycline; HSDB 3130; Klinomycin; MINOCYCLINE; Minociclina [Inn-Spanish]; Minocin; Minocyclin; Minocycline; Minocycline Hcl; Minocycline [Usan:Ban:Inn]; Minocyclinum [Inn-Latin]; Minocyn; Minomycin; Novo-Minocycline; Vectrin | ||
| Indication | For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by Rickettsiae, Upper respiratory tract infections caused by Streptococcus pneumoniee; For the treatment of asymptomatic carriers of Neisseria meningitidis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Minocycline, the most lipid soluble and most active tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. Minocycline is used to treat nongonococcal urethritis, mucopurulent cervicitis, acne vulgaris, and rheumatoid arthritis and some othet infections. Because of its lipid solubility, minocycline is able to eradicate the meningococcal carrier state in tears and saliva. | ||
| Mechanism Of Action | Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30 S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. | ||
| Minocycline News (When available) |
Individualized treatment options for rosacea 07 Mar 2006 Preliminary Study Shows Creatine and Minocycline May Warrant ... Feb 24, 2006 Preliminary Study Shows Creatine and Minocycline May Warrant ... Feb 23, 2006 Keep sick kids at home Feb 28, 2006 Pilot study suggests antibiotic, creatine may aid Parkinson’s Mar 2, 2006 Parkinson's Disease Clinical Trials will Include Co-Enzyme Q10 ... Feb 26, 2006 Compounds Could Slow Parkinson's Disease Feb 23, 2006 Substances to be probed for potential in slowing Parkinson's Feb 24, 2006 Compounds May Slow Parkinson's Disease Feb 23, 2006 (PZ) Medicis Announces FDA Approval of Broader Indication for ... Mar 2, 2006 New Leads in Slowing Parkinson's Feb 24, 2006 Health News - Compounds could slow Parkinson's disease Feb 24, 2006 Families struggle with ALS Mar 2, 2006 Compounds May Help in Treating Parkinson's Feb 25, 2006 Help for Parkinson's? Feb 23, 2006 Parkinson's studies test diet supplements Feb 24, 2006 Parkinson's research presents treatment options Feb 23, 2006 New Survey Reveals Common, Low-Cost Antibiotic Therapy May Have ... Feb 15, 2006 Medicis to Present at Merrill Lynch 17th Annual Global ... Feb 3, 2006 Cooler heads studied as treatment for strokes Jan 26, 2006 IRDF awards announced Jan 26, 2006 The ALS Association Awards TREAT ALS Funding to Three Clinical ... Jan 16, 2006 A 2-Week-On, 2-Week-Off Schedule Appears Optimal for BIBW 2992 in ... Nov 21, 2005 A Brief Honeymoon Nov 12, 2005 New Beauty: Coping with life in rosacea's red zone Nov 28, 2005 Medicis Board Unanimously Rejects Mentor Proposal Nov 20, 2005 Dermatologists discuss myths surrounding -- and treatments for ... Nov 10, 2005 Fresh from the pipeline: Tigecycline Oct 5, 2005 Medicis to Present at UBS Global Life Sciences Conference Sep 26, 2005 Cook's Spectrum Antibiotic-Impregnated Pediatric Catheter Approved ... Sep 26, 2005 Lyme disease symptoms still affect local resident Sep 25, 2005 Taking Antibiotics for Acne May Increase Risk of Upper Respiratory ... Sep 20, 2005 Many meds don't mix with the sun Sep 21, 2005 Medicis to Present at Thomas Weisel Partners Healthcare Tailwinds ... Sep 6, 2005 $3.4 million directed to key UW-Madison MS study Aug 10, 2005 ONLINE EXTRA: Forensic psychiatric evaluation for Jason McLaughlin Jul 23, 2005 Medicis to Present at Banc of America Securities 2005 Specialty ... Jul 25, 2005 | ||
| Dosage Forms | Capsules; Subgingival (sustained-release); IV Injection; | ||
| Drug_Category | Anti-bacterial Agents; Tetracyclines; ATC:A01AB23; ATC:J01AA08 | ||
| Absorption | rapidly absorbed from the gastrointestinal tract | ||
| Interactions |
Interactions for Minocycline: Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and iron-containing preparations. The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity. Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. | ||
| Toxicity | LD50=2380 mg/kg (rat, oral); LD50=3600 mg/kg (mouse, oral) | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 2-(amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione | ||
| Chemical Formula | C23H27N3O7 | ||
| Molecular Weight | 457.477 g/mol | ||
| Smiles String | CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=O)C(=C(N)O)C1=O)O)O)O)N(C)C | ||
| Melting Point | Not Available | ||
| Water Solubility | 5.2E+004 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | -0.508 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 11.1-22.1 hours | ||
| Protein Binding [%] | 55% and 76% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Minocycline.html http://www.rxlist.com/cgi/generic/minocycline.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00547 | ||
| CAS Registry Number | 10118-90-8 | ||
| KEGG Compound ID | C07225 | ||
| PubChem ID | SID:167749 | ||
| PharmGKB ID | PA450519 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2242080 |
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