Minocycline drug data and news

Minocycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Minocycline
Brand Names/Synonyms Alti-Minocycline; Apo-Minocycline; Arestin; BRN 3077644; CL 59806; DYNACIN; Dynacin; Gen-Minocycline; HSDB 3130; Klinomycin; MINOCYCLINE; Minociclina [Inn-Spanish]; Minocin; Minocyclin; Minocycline; Minocycline Hcl; Minocycline [Usan:Ban:Inn]; Minocyclinum [Inn-Latin]; Minocyn; Minomycin; Novo-Minocycline; Vectrin
Indication For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers caused by Rickettsiae, Upper respiratory tract infections caused by Streptococcus pneumoniee; For the treatment of asymptomatic carriers of Neisseria meningitidis
Sponsored links
Description Not Available
Pharmacology Minocycline, the most lipid soluble and most active tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. Minocycline is used to treat nongonococcal urethritis, mucopurulent cervicitis, acne vulgaris, and rheumatoid arthritis and some othet infections. Because of its lipid solubility, minocycline is able to eradicate the meningococcal carrier state in tears and saliva.
Mechanism Of Action Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30 S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
Minocycline News
(When available)

Individualized treatment options for rosacea  07 Mar 2006
...improvement. Oral tetracycline antibiotics, such as doxycycline or minocycline, are the most common oral medications used to treat rosacea. ... - News-Medical.net,

Preliminary Study Shows Creatine and Minocycline May Warrant ...  Feb 24, 2006
24, 2006 -- A National Institutes of Health-sponsored clinical trial with 200 Parkinson's disease patients has shown that creatine and minocycline may warrant ... - DG News

Preliminary Study Shows Creatine and Minocycline May Warrant ...  Feb 23, 2006
26, 2006— A National Institutes of Health sponsored clinical trial with 200 Parkinsons disease patients has shown that creatine and minocycline may warrant ... - PharmaLive.com (press release),

Keep sick kids at home  Feb 28, 2006
Minocycline, a prescription-only antibiotic that fights inflammation, and creatine, a muscle-enhancing dietary supplement also offer potential therapeutic ... - Hattiesburg American,

Pilot study suggests antibiotic, creatine may aid Parkinson’s  Mar 2, 2006
A pilot study, unveiled Thursday, suggests the two - the antibiotic minocycline and creatine, a substance produced in muscle tissue - may have some benefit. ... - Montreal Gazette,

Parkinson's Disease Clinical Trials will Include Co-Enzyme Q10 ...  Feb 26, 2006
...the symptoms. Various compounds will be tested including Co-Enzyme Q-10 (CoQ10), creatine, minocycline and GPI-1485. The National ... - Best Syndication,

Compounds Could Slow Parkinson's Disease  Feb 23, 2006
Also under consideration are Minocycline, a prescription-only antibiotic that fights inflammation and is thought to play a role in Parkinson's; and the dietary ... - Houston Chronicle,

Substances to be probed for potential in slowing Parkinson's  Feb 24, 2006
An antibiotic called Minocycline and a supplement called creatine often used by bodybuilders are the next two candidates for similar studies. ... - Seattle Times,

Compounds May Slow Parkinson's Disease  Feb 23, 2006
The antibiotic minocycline and the muscle-related compound creatine may slow the progression of Parkinson's disease, suggests a pilot study funded by the US ... - WWAY NewsChannel 3,

(PZ) Medicis Announces FDA Approval of Broader Indication for ...  Mar 2, 2006
The Company's products include the prescription brands RESTYLANE(R), DYNACIN(R) (minocycline HCl), LOPROX(R) (ciclopirox), OMNICEF(R) (cefdinir), PLEXION(R ... - Houston Chronicle,

New Leads in Slowing Parkinson's  Feb 24, 2006
Feb. 24, 2006 -- A new study shows that two compounds -- creatine and minocycline -- might deserve more research to see if they slow down Parkinson's disease. ... - WebMD

Health News - Compounds could slow Parkinson's disease  Feb 24, 2006
...study of whether certain compounds could slow the worsening of Parkinson's disease.A pilot study suggests the two - the antibiotic minocycline and creatine, a ... - Washington Examiner,

Families struggle with ALS  Mar 2, 2006
...quality of life. Peter Demmerle has also taken CoEnzyme Q10 (CoQ10), Minocycline, and Celebrex to help slow progression. “ALS stinks ... - New Canaan Advertiser,

Compounds May Help in Treating Parkinson's  Feb 25, 2006
The antibiotic minocycline and the amino acid creatine may have some benefit in treating Parkinson's disease, researchers reported at a Washington conference. ... - Los Angeles Times,

Help for Parkinson's?  Feb 23, 2006
An antibiotic (minocycline) and a muscle-related compound (creatine) are leading candidates for the major government research into whether certain compounds ... - KWWL,

Parkinson's studies test diet supplements  Feb 24, 2006
Minocycline, a prescription-only antibiotic that fights inflammation, and the dietary supplement creatine would be involved in later studies. ... - Kentucky.com,

Parkinson's research presents treatment options  Feb 23, 2006
A more recent study didn't show whether the compounds creatine and minocycline can protect brain cells, but it found they're not useless, and are worth further ... - WIS,

New Survey Reveals Common, Low-Cost Antibiotic Therapy May Have ...  Feb 15, 2006
..."As the survey results suggest, antibiotics such as minocycline, a low- cost and commonly prescribed antibiotic with minimal side-effects, may offer an ... - Yahoo! News (press release)

Medicis to Present at Merrill Lynch 17th Annual Global ...  Feb 3, 2006
The Company's products include the prescription brands RESTYLANE(R), DYNACIN(R) (minocycline HCl), LOPROX(R) (ciclopirox), OMNICEF(R) (cefdinir), PLEXION(R ... - Genetic Engineering News,

Cooler heads studied as treatment for strokes  Jan 26, 2006
24 hours of intravenous magnesium sulfate along with a widely used protein (Albumin), anticholesterol medication (Atorvastatin) and antibiotic (Minocycline). ... - Edmonton Journal,

IRDF awards announced  Jan 26, 2006
The goal of the study is to determine whether minocycline, a common antibiotic that has shown to reduce the loss of sensory hair cells that detect sounds in ... - University at Buffalo Reporter,

The ALS Association Awards TREAT ALS Funding to Three Clinical ...  Jan 16, 2006
120 patients. Celecoxib and minocycline will each be tested in combination with creatine, in separate groups of ALS patients. If ... - Genetic Engineering News,

A 2-Week-On, 2-Week-Off Schedule Appears Optimal for BIBW 2992 in ...  Nov 21, 2005
...at a dose of 70 mg appears safe in patients with solid tumors and the adverse effects can be easily controlled with loperamide and minocycline, according to a ... - DG News

A Brief Honeymoon  Nov 12, 2005
...time to start. She made an appointment with a local dermatologist, who gave her a medicine called minocycline. It's an antibiotic ... - New York Times,

New Beauty: Coping with life in rosacea's red zone  Nov 28, 2005
If these medications fail, your dermatologist may prescribe oral antibiotics, perhaps tetracycline or its derivatives minocycline and doxcycline. ... - Naples Daily News (subscription),

Medicis Board Unanimously Rejects Mentor Proposal  Nov 20, 2005
The Company's products include the prescription brands RESTYLANE(R), DYNACIN(R) (minocycline HCl), LOPROX(R) (ciclopirox), OMNICEF(R) (cefdinir), PLEXION(R ... - Business Wire (press release),

Dermatologists discuss myths surrounding -- and treatments for ...  Nov 10, 2005
...ointments have failed to clear the complexion, a dermatologist may prescribe an oral antibiotic, such as tetracycline, doxycycline, minocycline or erythromycin ... - Victorville Daily Press,

Fresh from the pipeline: Tigecycline  Oct 5, 2005
In the 1990s, it was discovered that introducing substituents at position 9 of minocycline resulted in compounds that not only had activity typical of earlier ... - Nature.com (subscription),

Medicis to Present at UBS Global Life Sciences Conference  Sep 26, 2005
The Company's products include the prescription brands RESTYLANE(R), DYNACIN(R) (minocycline HCl), LOPROX(R) (ciclopirox), OMNICEF(R) (cefdinir), PLEXION(R ... - PharmaLive.com (press release),

Cook's Spectrum Antibiotic-Impregnated Pediatric Catheter Approved ...  Sep 26, 2005
...of children acquiring life-threatening infections during intensive care unit stays, Cook Critical Care's Spectrum(R) Minocycline/Rifampin Impregnated catheter ... - Business Wire (press release),

Lyme disease symptoms still affect local resident  Sep 25, 2005
...day since May. "I'm currently on 1,000 mg of Ceftin and 200 mg. of minocycline, which are antibiotics," she said. "I have a B12 ... - Keyser Mineral Daily News Tribune,

Taking Antibiotics for Acne May Increase Risk of Upper Respiratory ...  Sep 20, 2005
...colleagues. "Topical erythromycin and clindamycin and oral minocycline, doxycycline, and tetracycline are frequently used to treat acne. ... - Medscape (subscription)

Many meds don't mix with the sun  Sep 21, 2005
Fulvicin, Gris-PEG), isoniazid (Nydrazid), levofloxacin (Levaquin), lomefloxacin (Maxaquin), metronidazole (Flagyl), minocycline (Minocin), moxifloxacin (Ave ... - Pioneer Press,

Medicis to Present at Thomas Weisel Partners Healthcare Tailwinds ...  Sep 6, 2005
The Company's products include the prescription brands RESTYLANE(R), DYNACIN(R) (minocycline HCl), LOPROX(R) (ciclopirox), OMNICEF(R) (cefdinir), PLEXION(R ... - Business Wire (press release),

$3.4 million directed to key UW-Madison MS study  Aug 10, 2005
The project, Duncan adds, will also expand studies of the antibiotic minocycline, a drug that has shown potential for protecting nerve fibers and mitigating ... - University of Wisconsin-Madison University Communications,

ONLINE EXTRA: Forensic psychiatric evaluation for Jason McLaughlin  Jul 23, 2005
He has severe acne on his face chest and back. His current medications for acne are minocycline and lotions. He is allergic to cats. ... - Grand Forks Herald

Medicis to Present at Banc of America Securities 2005 Specialty ...  Jul 25, 2005
The Company's products include the prescription brands RESTYLANE(R), DYNACIN(R) (minocycline HCl), LOPROX(R) (ciclopirox), OMNICEF(R) (cefdinir), PLEXION(R ... - Business Wire (press release)

Dosage Forms Capsules; Subgingival (sustained-release); IV Injection;
Drug_Category Anti-bacterial Agents; Tetracyclines; ATC:A01AB23; ATC:J01AA08
Absorption rapidly absorbed from the gastrointestinal tract
Interactions Interactions for Minocycline:

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, and iron-containing preparations.

The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.

Toxicity LD50=2380 mg/kg (rat, oral); LD50=3600 mg/kg (mouse, oral)
Organisms Affected Enteric bacteria and other eubacteria
Chemical IUPAC Name 2-(amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione
Chemical Formula C23H27N3O7
Molecular Weight 457.477 g/mol
Smiles String CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=O)C(=C(N)O)C1=O)O)O)O)N(C)C
Melting Point Not Available
Water Solubility 5.2E+004 mg/L
State Solid
LogP/Hphobicity -0.508
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 11.1-22.1 hours
Protein Binding [%] 55% and 76%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Minocycline.html
http://www.rxlist.com/cgi/generic/minocycline.htm
Drug Type Approved Drug
Accession No APRD00547
CAS Registry Number 10118-90-8
KEGG Compound ID C07225
PubChem ID SID:167749
PharmGKB ID PA450519
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2242080

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org