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Mimosine
drug data and news
Mimosine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Mimosine
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| Brand Names/Synonyms |
L-Mimosine; Leucaenine; Leucaenol; Leucenine; Leucenol; Mimosin; Mimosine |
| Indication |
Not Available |
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Description |
Not Available |
| Pharmacology |
Mimosine inhibits DNA synthesis at the level of elongation of nascent chains by altering deoxyribonucleotide metabolism. It arrests the cell cycle in the late G(1) phase. |
| Mechanism Of Action |
Mimosine causes inhibition of DNA replication, changes in the progression of the cells in the cell cycle, and apoptosis. Mimosine appears to introduce breaks into DNA. Mimosine is an iron/zinc chelator. Iron depletion induces DNA double-strand breaks in treated cells, and activates a DNA damage response that results in focal phosphorylation of histones. This leads to inhibition of DNA replication and/or DNA elongation. Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT). Inhibition of serine hydroxymethyltransferase is moderated by a zinc responsive unit located in front of the SHMT gene. |
Mimosine News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Antineoplastic Agents; |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-amino-3-(3-hydroxy-4-oxo-1H-pyridin-1-yl)-propanoicacid |
| Chemical Formula |
C8H10N2O4 |
| Molecular Weight |
198.176 g/mol |
| Smiles String |
C1=CN(C=C(C1=O)O)CC(C(=O)O)N |
| Melting Point |
228 °C |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
-3.668 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
>99.5% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00647 |
| CAS Registry Number |
500-44-7 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:7336 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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