Metronidazole drug data and news

Metronidazole drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Metronidazole
Brand Names/Synonyms Acromona; Anagiardil; Apo-Metronidazole; Arilin; Atrivyl; Bayer 5360; Benzoylmetronildazole; Bexon; Clont; Cont; Danizol; Deflamon; Deflamon-Wirkstoff; Efloran; Elyzol; Entizol; Eumin; Flagemona; Flagesol; Flagil; Flagyl; Flagyl Er; Flagyl I.V.; Flagyl I.V. Rtu; Flegyl; Fossyol; Giatricol; Gineflavir; Helidac; Klion; Klont; Meronidal; Methronidazole; Metric 21; Metro Cream &Amp; Gel; Metro I.V.; Metro I.V. In Plastic Container; Metrocream; Metrogel; Metrogel-Vaginal; Metrolag; Metrolotion; Metrolyl; Metromidol; Metronidaz; Metronidazol; Metronidazole; Metronidazole Benzoate; Metronidazole Hcl; Metronidazole in Plastic Container; Metronidazolo; Metrotop; Mexibol; Monagyl; Monasin; Nalox; Neo-Tric; Nida; Nidagel; Noritate; Novonidazol; Orvagil; Protostat; RP 8823; Rathimed; Sanatrichom; Satric; Takimetol; Trichazol; Trichex; Tricho Cordes; Tricho-Gynaedron; Trichocide; Trichomol; Trichomonacid 'Pharmachim'; Trichopal; Trichopol; Tricocet; Tricom; Tricowas B; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Trivazol; Vagilen; Vagimid; Vertisal; Wagitran; Zadstat
Indication Treatment of acute acne rosacea
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Description Not Available
Pharmacology Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Mechanism Of Action Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then disrupts DNA's helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.
Metronidazole News
(When available)

A New Product Star Born Every 3 Minutes in 2005; Graceful Aging ...  07 Mar 2006
...formula. Even toilet paper is catering to individual preferences, with the Renova debut of black toilet paper in Europe. Outside ... - Business Wire (press release),

Consortium of Russian private and institutional investors headed ...  Mar 3, 2006
Consortium of Russian private and institutional investors headed by direct investment fund Renova Capital has purchased 100 percent equity stake in Corbina ... - Analytical Information Agency,

Goldman, Sistema, Renova form Russia property fund  Feb 24, 2006
Sachs (GS.N: Quote, Profile, Research) has joined forces with Russian holding companies AFK Sistema (SSAq.L: Quote, Profile, Research) and Renova to create a ... - Reuters

Business in Brief  Mar 5, 2006
Renova, the holding company controlled by billionaire Viktor Vekselberg, has acquired Moscow-based Corbina Telecom for $146 million from US phone company IDT. ... - The Moscow Times,

Investor consortium buys Corbina Telecom  Mar 3, 2006
RBC, 03.03.2006, Moscow 17:36:20.A consortium of Russian private and institutional investors headed by direct investment fund Renova Capital has acquired a 100 ... - RosBusinessConsulting,

Corbina Telecom ZAO /Consortium/ agreed to acquire Corbina Telecom ...  Mar 3, 2006
March 3, 2006 - Moscow, MK, Russian Federation — A consortium of institutional and private investors headed by Renova Capital acquired Corbina Telecom ZAO ... - Baystreet.ca,

IDT Corporation Announces Completion of Sale of Corbina Telecom ...  Mar 6, 2006
IDT, IDT.C) today announced that it has sold its Corbina Telecom business to a consortium of institutional and private investors headed by Renova Capital, for ... - dBusinessNews Newark (press release),

IDT Closes Sale of Russian Telecom Business  Mar 3, 2006
...in Newark has completed the sale of its Corbina Telecom business for $146 million to a group of private and institutional investors led by Renova Capital in ... - Business New Jersey (subscription),

IDT Corporation Announces Completion of Sale of Corbina Telecom ...  Mar 3, 2006
...today announced thatit has sold its Corbina Telecom business to a consortium ofinstitutional and private investors headed by Renova Capital, forapproximately ... - Finanzen.net,

No half measures -- Vekselberg sells out of Russia  Feb 23, 2006
Vekselberg cannot float SUAL or Renova abroad, because Fleming cannot find a strategic investor, or a share market, which wants to buy the assets. ... - Mineweb,

Yekaterinburg nonferrous plant to reorganize into ...  Mar 2, 2006
March 1 (Interfax) - Shareholders of the Yekaterinburg Nonferrous Metals Processing Plant, a division of the Renova group, will set up a new company called ... - TMCnet

DJ Barrick Gold In Talks For Russian Assets-Report  Feb 20, 2006
...(ABX) is in talks to buy the Russian and Kazakh gold assets of Russia's ZAO Renova Group, Russian newspaper Vedomosti reported Monday. ... - TMCnet

Business news in brief from around New Jersey  Mar 3, 2006
...said it has sold its Russia-based Corbina Telecom business for about $146 million to a group of institutional and private investors headed by Renova Capital. ... - Newsday,

Business briefs  Mar 4, 2006
...announced Friday that it has sold its Corbina Telecom business for $146 million to a consortium of institutional and private investors headed by Renova Capital ... - NorthJersey.com,

GDP Rose 4.7% in January  Feb 19, 2006
Renova, the holding company controlled by billionaire Viktor Vekselberg, is in talks to sell its gold assets to Barrick Gold, Interfax reported, citing an ... - The Moscow Times,

Ethanol ­ now is a good time  Feb 5, 2006
...that’s now underway will double production capacity, said Dan Schwartzkopf, senior vice president of Wyoming Ethanol’s parent company Renova Energy. ... - Upper Valley Free Press,

Russian Firms Urged to Invest in Third World  Mar 1, 2006
...signal a comeback to some of the Soviet Union's former spheres of influence, ranging from the CIS to Latin America and Africa, said Renova chairman Viktor ... - The Moscow Times,

Shakers: Pfizer reduces bonus for McKinnell by 7%  Feb 26, 2006
AFK Sistema, a holding company controlled by Yevtushenkov, and Renova Industries, owned by Vekselberg, signed the agreement with Whitehall Street Real Estate ... - International Herald Tribune,

Business in Brief  Mar 1, 2006
Interfax said. Vekselberg controls SUAL through his Renova holding, which also owns about one-eighth of TNK-BP. (Bloomberg). Sistema ... - The Moscow Times,

News of the Weird  Feb 9, 2006
The Portuguese paper producer Renova introduced black toilet paper in France last fall (and expect to introduce it in the US soon). ... - Duluth News Tribune,

Options for Adult Acne  Feb 7, 2006
If your acne doesn’t respond, you may want to see your care provider for a stronger prescription acne lotion such a tretinoin (Retin-A, Renova) or adapaline ... - Fashion Monitor Toronto,

news of the weird  Feb 1, 2006
...(2) The Portuguese paper producer Renova introduced black toilet paper in France last fall (and expect to introduce it in the US soon). ... - Wilkes Barre Times-Leader,

Lucky lieutenant escapes serious injury in Iraq bombing  Feb 22, 2006
...protected. A native of Renova, Pa., Kurt is a graduate of Bucktail High School there and frequently visits his grandparents in Parrish. ... - Sarasota Herald-Tribune,

Depot, bridge designer wins awards  Feb 23, 2006
LIMA — The firm that designed and built the North Street bridge and handled the renova-tion of the former Lima train depot won a pair of awards for its work ... - LimaOhio.com,

Chuck Shepherd: News of the Weird  Feb 8, 2006
...(2) Renova, a Portuguese paper producer, introduced black toilet paper in France last fall and expects to introduce it in the United States soon. ... - Arizona Daily Star,

Highveld honey-pot attracts Russian high-flies  Feb 3, 2006
On the ground, at the Kalahari manganese field, locals tell stories of helicopter landings of men from Vekselberg’s Renova group, who drop in to sniff their ... - Mineweb,

Market Report: Merger chatter sends Northern Rock on a roll  Feb 17, 2006
...offers. Renova Energy succumbed to a bout of profit-taking after rising more than 280 per cent since listing at 69p in June. The ... - Independent,

Market Report: Bidders circle rudderless Cable & Wireless  Feb 9, 2006
The AIM-listed Renova Energy was also in favour as the company reported record monthly production of ethanol in December of 477 million barrels. ... - Independent,

TNK-BP offers Gazprom control of Kovykta field-paper  Feb 6, 2006
Russian conglomerate Alfa Group has a 25 percent stake in TNK-BP, Russia's second-largest oil company set up in 2003, while Renova and Access, companies owned ... - Reuters

Developer buys land near spot for park  Feb 9, 2006
..."A single building by itself won't do that.". Downtown housing, in general, has consisted mostly of building renova- tions. Several ... - Houston Chronicle,

Africa a hot topic at mining indaba  Feb 8, 2006
We saw the Rand Merchant Bank talking with Renova, which is a Russian company, which we know is very keen to invest in South Africa, but is going about it in a ... - iAfrica.com,

UPDATE 1-BP denies TNK-BP offered Kovykta field to Gazprom  Feb 7, 2006
Russian conglomerate Alfa Group has a 25 percent stake in TNK-BP, which is Russia's second-largest oil company, while Renova and Access, companies owned by ... - Reuters

Paper: TNK-BP Eyes Deal on Siberia Field  Feb 7, 2006
Conglomerate Alfa Group has a 25 percent stake in TNK-BP, which is Russia's second-largest oil company and was set up in 2003, while Renova and Access ... - The Moscow Times,

SUAL, Fleming Family Drift Apart  Feb 15, 2006
...in SUAL International have been bought out by the company itself and paid off,� specified Vladimir Kuznetsov, investment director at Renova Group (which ... - Kommersant,

London close: Footsie through 5  Feb 9, 2006
...expectations. Among the minnows, Renova did well as the ethanol producer announced record monthly production in December 2005. Network ... - Life Style Extra,

Berlusconi Meets Russian Businessmen  Feb 13, 2006
Russian business at the meeting was represented by the Russian president’s aide Sergey Yastrzhembsky, Renova’s head Viktor Vekselberg, Sistema’ chair of ... - Kommersant,

Chatwin, White honored  Feb 14, 2006
He also led Alcorn in wins (5). White, a 5-foot-9, 170-pounder from Renova, Miss., tied for the SWAC lead in triples in 2005 with six. ... - Alcorn State Sports,

Addo added to Vardar side  Feb 11, 2006
Pance Ristevski have made the step up from the Vtora Liga to sign for FK Pobeda, who have also signed Obilic’s Marko Jovanovic, while FK Renova have turned ... - uefa.com,

Bank Giants Hold Key to Footsie Winning Streak  Feb 10, 2006
...one year. Renova Energy, an independent producer of ethanol, jumped 181/2p to 227p on a bullish 9-month update. Biofuels Corporation ... - International News Service,

Heineken to produce Zlaty Bazant beer in Russia.  Feb 10, 2006
Patra" (Ekaterinburg) and "Stapan Razin" (Saint Petersburg) as well has signed an agreement on the acquisition of Baikal Brewery Company from Renova and Ivan ... - Analytical Information Agency,

Small Talk: Oil explorer's investors excited over good news in the ...  Feb 5, 2006
For example, the ethanol producer Renova Energy and the recruitment group Multi both trade at less than three times forecast earnings. ... - Independent,

Vitaliy Nedelskiy appointed GD of turbine works of Yekaterinburg  Feb 5, 2006
Yekaterinburg. Former GD Sergei Zyryanov was appointed Chair of the Board, as had been suggested by Renova Group, one of the shareholders. ... - Ural Business Consulting,

Dosage Forms Tablets, IV injection
Drug_Category Radiation-Sensitizing Agents; Antiprotozoals; Anti-Infectives; Antiprotozoals; ATC:A01AB17; ATC:D06BX01; ATC:G01AF01; ATC:J01XD01; ATC:P01AB01
Absorption well absorbed
Interactions -->Interactions for Metronidazole:

Oral metronidazole has been reported to potentiate the anticoagulant effect of coumarin and warfarin, resulting in a prolongation of prothrombin time. Drug interactions should be kept in mind when METROGELÒ (metronidazole gel), 1% is prescribed for patients who are receiving anticoagulant treatment, although they are less likely to occur with topical metronidazole administration because of low absorption.

 

Toxicity Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Organisms Affected Not Available
Chemical IUPAC Name 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
Chemical Formula C6H9N3O3
Molecular Weight 171.154 g/mol
Smiles String CC1=NC=C(N1CCO)[N+](=O)[O-]
Melting Point 160 °C
Water Solubility <0.1g/100mL
State Solid
LogP/Hphobicity -0.262
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 8 hours
Protein Binding [%] Less than 20%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Metronidazole.html
http://www.rxlist.com/cgi/generic2/metron.htm
Drug Type Approved Drug
Accession No APRD00631
CAS Registry Number 443-48-1
KEGG Compound ID C07203
PubChem ID SID:286613
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 649074

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