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Metronidazole
drug data and news
Metronidazole drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Metronidazole | ||
| Brand Names/Synonyms | Acromona; Anagiardil; Apo-Metronidazole; Arilin; Atrivyl; Bayer 5360; Benzoylmetronildazole; Bexon; Clont; Cont; Danizol; Deflamon; Deflamon-Wirkstoff; Efloran; Elyzol; Entizol; Eumin; Flagemona; Flagesol; Flagil; Flagyl; Flagyl Er; Flagyl I.V.; Flagyl I.V. Rtu; Flegyl; Fossyol; Giatricol; Gineflavir; Helidac; Klion; Klont; Meronidal; Methronidazole; Metric 21; Metro Cream &Amp; Gel; Metro I.V.; Metro I.V. In Plastic Container; Metrocream; Metrogel; Metrogel-Vaginal; Metrolag; Metrolotion; Metrolyl; Metromidol; Metronidaz; Metronidazol; Metronidazole; Metronidazole Benzoate; Metronidazole Hcl; Metronidazole in Plastic Container; Metronidazolo; Metrotop; Mexibol; Monagyl; Monasin; Nalox; Neo-Tric; Nida; Nidagel; Noritate; Novonidazol; Orvagil; Protostat; RP 8823; Rathimed; Sanatrichom; Satric; Takimetol; Trichazol; Trichex; Tricho Cordes; Tricho-Gynaedron; Trichocide; Trichomol; Trichomonacid 'Pharmachim'; Trichopal; Trichopol; Tricocet; Tricom; Tricowas B; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Trivazol; Vagilen; Vagimid; Vertisal; Wagitran; Zadstat | ||
| Indication | Treatment of acute acne rosacea | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea. | ||
| Mechanism Of Action | Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then disrupts DNA's helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death. | ||
| Metronidazole News (When available) |
A New Product Star Born Every 3 Minutes in 2005; Graceful Aging ... 07 Mar 2006 Consortium of Russian private and institutional investors headed ... Mar 3, 2006 Goldman, Sistema, Renova form Russia property fund Feb 24, 2006 Business in Brief Mar 5, 2006 Investor consortium buys Corbina Telecom Mar 3, 2006 Corbina Telecom ZAO /Consortium/ agreed to acquire Corbina Telecom ... Mar 3, 2006 IDT Corporation Announces Completion of Sale of Corbina Telecom ... Mar 6, 2006 IDT Closes Sale of Russian Telecom Business Mar 3, 2006 IDT Corporation Announces Completion of Sale of Corbina Telecom ... Mar 3, 2006 No half measures -- Vekselberg sells out of Russia Feb 23, 2006 Yekaterinburg nonferrous plant to reorganize into ... Mar 2, 2006 DJ Barrick Gold In Talks For Russian Assets-Report Feb 20, 2006 Business news in brief from around New Jersey Mar 3, 2006 Business briefs Mar 4, 2006 GDP Rose 4.7% in January Feb 19, 2006 Ethanol  now is a good time Feb 5, 2006 Russian Firms Urged to Invest in Third World Mar 1, 2006 Shakers: Pfizer reduces bonus for McKinnell by 7% Feb 26, 2006 Business in Brief Mar 1, 2006 News of the Weird Feb 9, 2006 Options for Adult Acne Feb 7, 2006 news of the weird Feb 1, 2006 Lucky lieutenant escapes serious injury in Iraq bombing Feb 22, 2006 Depot, bridge designer wins awards Feb 23, 2006 Chuck Shepherd: News of the Weird Feb 8, 2006 Highveld honey-pot attracts Russian high-flies Feb 3, 2006 Market Report: Merger chatter sends Northern Rock on a roll Feb 17, 2006 Market Report: Bidders circle rudderless Cable & Wireless Feb 9, 2006 TNK-BP offers Gazprom control of Kovykta field-paper Feb 6, 2006 Developer buys land near spot for park Feb 9, 2006 Africa a hot topic at mining indaba Feb 8, 2006 UPDATE 1-BP denies TNK-BP offered Kovykta field to Gazprom Feb 7, 2006 Paper: TNK-BP Eyes Deal on Siberia Field Feb 7, 2006 SUAL, Fleming Family Drift Apart Feb 15, 2006 London close: Footsie through 5 Feb 9, 2006 Berlusconi Meets Russian Businessmen Feb 13, 2006 Chatwin, White honored Feb 14, 2006 Addo added to Vardar side Feb 11, 2006 Bank Giants Hold Key to Footsie Winning Streak Feb 10, 2006 Heineken to produce Zlaty Bazant beer in Russia. Feb 10, 2006 Small Talk: Oil explorer's investors excited over good news in the ... Feb 5, 2006 Vitaliy Nedelskiy appointed GD of turbine works of Yekaterinburg Feb 5, 2006 | ||
| Dosage Forms | Tablets, IV injection | ||
| Drug_Category | Radiation-Sensitizing Agents; Antiprotozoals; Anti-Infectives; Antiprotozoals; ATC:A01AB17; ATC:D06BX01; ATC:G01AF01; ATC:J01XD01; ATC:P01AB01 | ||
| Absorption | well absorbed | ||
| Interactions |
-->Interactions for Metronidazole: Oral metronidazole has been reported to potentiate the anticoagulant effect of coumarin and warfarin, resulting in a prolongation of prothrombin time. Drug interactions should be kept in mind when METROGELÒ (metronidazole gel), 1% is prescribed for patients who are receiving anticoagulant treatment, although they are less likely to occur with topical metronidazole administration because of low absorption. | ||
| Toxicity | Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat) | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol | ||
| Chemical Formula | C6H9N3O3 | ||
| Molecular Weight | 171.154 g/mol | ||
| Smiles String | CC1=NC=C(N1CCO)[N+](=O)[O-] | ||
| Melting Point | 160 °C | ||
| Water Solubility | <0.1g/100mL | ||
| State | Solid | ||
| LogP/Hphobicity | -0.262 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 8 hours | ||
| Protein Binding [%] | Less than 20% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Metronidazole.html http://www.rxlist.com/cgi/generic2/metron.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00631 | ||
| CAS Registry Number | 443-48-1 | ||
| KEGG Compound ID | C07203 | ||
| PubChem ID | SID:286613 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 649074 |
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