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Metoprolol
drug data and news
Metoprolol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Metoprolol | ||
| Brand Names/Synonyms | Beloc; Betaloc; CGP 2175; H 93/26; H-23/96; LOPRESSOR HCT; Lopresor; Lopresoretic; Lopressor; Metoprolol; Metoprolol Tartrate; Metroprolol; Prelis; Selo-Zok; Seloken; Selopral; Toprol; Toprol-Xl | ||
| Indication | For the treatment of hypertension and angina pectoris | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA). | ||
| Mechanism Of Action | Like betaxolol and atenolol, metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure. | ||
| Metoprolol News (When available) |
Recruitment Temporarily Suspended In An International Phase III ... Feb 20, 2006 Chemotherapy and Radiation Therapy May Replace Surgery in Early ... Mar 3, 2006 Single hit chemo guides therapy for larynx cancer Feb 27, 2006 Chemotherapy Given Directly to Liver Improves Survival for ... Feb 27, 2006 Merck KGaA Receives EMEA Positive Opinion for Erbitux in Head and ... Feb 23, 2006 Pro-Pharmaceuticals to Present Abstract & Poster at Mass ... Mar 2, 2006 Oxaliplatin Safely Stopped with FOLFOX Regimen for Colorectal ... Feb 21, 2006 SKIN CANCER Mar 2, 2006 Subcutaneous Amifostine Feasible During Radiotherapy for Head and ... Mar 1, 2006 Patients Of UK's Second Biggest Killer To Gain Access To ... Feb 28, 2006 Avastin May Cause Leukoencephalopathy Syndrome Mar 2, 2006 Merck KGaA Receives EMEA Positive Opinion for Erbituxin Head and ... Feb 23, 2006 Visualization of Telomerase Reverse Transcriptase (hTERT) Promoter ... Feb 14, 2006 Patients Prefer Xeloda® to 5-Flurouracil in Treatment of ... Feb 15, 2006 Xeloda Shows Benefits as First Choice for Metastatic Breast Cancer ... Feb 22, 2006 Adjuvant Docetaxel More Effective Than Vinorelbine for Early ... Feb 23, 2006 Mangafodipir appears to increase the cancer-killing ability of ... Feb 20, 2006 Xaliproden Reduces Occurrence Of Severe Peripheral Sensory ... Feb 23, 2006 Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for ... Feb 22, 2006 Recurrence-Free Survival Improved with Taxotere® Compared to ... Feb 23, 2006 CoFactor™ (5,10-methylenetetrahydrofolate) May Enhance Activity ... Feb 3, 2006 ADVENTRX CoFactor Phase IIb Trial Surpasses 50% Enrollment ... Feb 14, 2006 Roche Stops Recruiting Patients for Avastin Test (Update3) Feb 13, 2006 Roche Stops Recruiting Patients for Avastin Study (Update7) Feb 13, 2006 Roche Stops Recruiting Patients for Avastin Study (Update8) Feb 13, 2006 Common MRI Drug May Help Fight Cancer Feb 14, 2006 Genentech/Roche: trial delay won't choke Avastin's growth Feb 13, 2006 Study Sets Treatment Standard for Elderly With Colon Cancer Feb 10, 2006 Colon cancer chemotherapies OK for elderly Feb 10, 2006 Drugs Increase Chemotherapy's Cancer-Killing Abilities Feb 14, 2006 MRI Contrast Agent Enhances Chemotherapy's Cancer Killing Feb 15, 2006 Roche halts enrollment in Avastin trial Feb 13, 2006 ADVENTRX to Present at BIO CEO on February 14 Feb 3, 2006 Xaliproden May Reduce Side Effect Caused by Eloxatin® in ... Feb 6, 2006 CoFactor™ Plus 5-FU Provides Large Response in Metastatic ... Feb 1, 2006 Xaliproden May Reduce Side Effect Caused by Eloxatin® in ... Feb 2, 2006 Meta-Analysis Indicates Improved Survival with Addition of ... Feb 1, 2006 | ||
| Dosage Forms | Tablets | ||
| Drug_Category | Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; Adrenergic Agents; ATC:C07AB02; ATC:C07AB52 | ||
| Absorption | rapid and complete, 50% | ||
| Interactions |
Interactions for Metoprolol: Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with extended release metoprolol succinate plus a catecholamine depletor should therefore be closely observed for evidence of hypotension or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. | ||
| Toxicity | LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090mg/kg (orally in mice) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 1-[4-(2-methoxyethyl)phenoxy]-3-(1-methylethylamino)propan-2-ol | ||
| Chemical Formula | C15H25NO3 | ||
| Molecular Weight | 267.364 g/mol | ||
| Smiles String | CC(C)NCC(COC1=CC=C(C=C1)CCOC)O | ||
| Melting Point | 120 oC (tartarate salt) | ||
| Water Solubility | 16.9 mg/mL | ||
| State | white, practically odorless, crystalline powder | ||
| LogP/Hphobicity | 2.477 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Primarily hepatic | ||
| Half Life | 3-7 hours | ||
| Protein Binding [%] | 12% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Metoprolol.html http://www.rxlist.com/cgi/generic/metopxl.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00208 | ||
| CAS Registry Number | 37350-58-6 | ||
| KEGG Compound ID | C07202 | ||
| PubChem ID | SID:205122 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2253518 |
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