|
|
|
|
|
Methysergide
drug data and news
Methysergide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Methysergide | ||
| Brand Names/Synonyms | Sansert; Deseril; Desernil; Desernyl; Deseryl; Methyllysergic acid butanolamide; Methysergid; Methysergide [USAN:BAN:INN]; Methysergidum [INN-Latin]; Metisergide [DCIT]; Metisergido [INN-Spanish]; N-(1-(Hydroxymethyl)propyl)-1-methyl-dextro-(+)-lysergamide; N-(alpha-(Hydroxymethyl)propyl)-1-methyl-dextro-lysergamide | ||
| Indication | For the treatment of vascular headache | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Methysergide has been shown, in vitro and in vivo, to inhibit or block the effects of serotonin, a substance which may be involved in the mechanism of vascular headaches. Serotonin has been variously described as a central neurohumoral agent or chemical mediator, as a "headache substance" acting directly or indirectly to lower pain threshold, as an intrinsic "motor hormone" of the gastrointestinal tract, and as a "hormone" involved in connective tissue reparative processes. | ||
| Mechanism Of Action | Methysergide is serotonin antagonists acts on central nervous system (CNS), which directly stimulates the smooth muscle leading to vasoconstriction. Some alpha-adrenergic blocking activity has been reported. Suggestions have been made by investigators as to the mechanism whereby Methysergide produces its clinical effects, but this has not been finally established, although it may be related to the antiserotonin effect. . | ||
| Methysergide News (When available) |
Times Online, ...at night. Methysergide is a partial 5HT antagonist but its side-effects, including nausea and dizziness, can be disturbing. These ... | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Vasoconstrictor Agents; Serotonin Antagonists; Sympatholytics; ATC:N02CA04 | ||
| Absorption | Rapid | ||
| Interactions | Interactions for Methysergide: Methysergide may reverse the analgesic activity of narcotic analgesics. Concurrent use with vasoconstrictor agents including ergot alkaloids, sumatriptan, and nicotine (e.g. smoking) may result in enhanced vasoconstriction. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | C21H27N3O2 | ||
| Molecular Weight | 353.458 g/mol | ||
| Smiles String | CCC(CO)NC(=O)C1CN(C2CC3=CN(C4=CC=CC(=C34)C2=C1)C)C | ||
| Melting Point | 195 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 1.55 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Methysergide.html http://www.rxlist.com/cgi/generic3/sansert.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00463 | ||
| CAS Registry Number | 361-37-5 | ||
| KEGG Compound ID | C07199 | ||
| PubChem ID | 9408 | ||
| PharmGKB ID | PA450471 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 27499 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |