Methylphenidate drug data and news

Methylphenidate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Methylphenidate
Brand Names/Synonyms 4311/B Ciba; C 4311; CHEMBANK1663; Calocain; Centedein; Centedrin; Centedrine; Centredin; Concerta; Dea No. 1724; Focalin; Focalin Xr; HSDB 3126; METHYLPHEN; Meridil; Metadate; Metadate Cd; Metadate Er; Methyl Phenidyl Acetate; Methylin; Methylin Er; Methylofenidan; Methylphenidan; Methylphenidate; Methylphenidate Hcl; Methylphenidate Hydrochloride; Methylphenidatum [Inn-Latin]; Methylphenidylacetate Hydrochloride; Methypatch; Metilfenidat Hydrochloride; Metilfenidato [Inn-Spanish]; Metilfenidato [Italian]; Phenidylate; Plimasine; Pms-Methylphenidate; Riphenidate; Ritalin; Ritalin Hydrochloride; Ritalin La; Ritalin Sr; Ritalin-Sr; Ritaline; Ritcher Works
Indication Children with attention deficit disorders
Sponsored links
Description Not Available
Pharmacology Methylphenidate, a central nervous system stimulant chemically similar to the amphetamines, is used to treat narcolepsy, attention-deficit hyperactivity disorder (ADHD) in children, post-stroke depression or other depressive disorders.
Mechanism Of Action Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result.
Methylphenidate News
(When available)

Gozo tabloid falls off the edge  07 Mar 2006
Ever heard of The Edge? Probably not. But for the last couple of months it has been a Gozitan mouthpiece of sorts, an uncontroversial ... - Malta Today,

Commentary by Mark Creech  07 Mar 2006
A former writer for a British tabloid now spends his time informing the world about Christians, including those being persecuted for their faith. ... - Agape Press,

TABLOID TALK  Mar 5, 2006
...* The Sunday Express: 'Sir Alex Ferguson has entered the scramble to sign Atletico Madrid's Fernando Torres.'. * The Mirror say that ... - Redissue,

Tabloid Shocker!  Mar 3, 2006
And so Altman, Pecker, and Fuller seem to be trapped in tabloid hell. ... In 1999, Timothy Noah covered Roger Altman's entry into the tabloid business. ... - Slate

Tabloid off streets  Mar 4, 2006
The tabloid Al Usbouyia is temporarily off the streets for "internal reasons", editor-in-chief Nada Mohammed said last night. "We ... - Gulf Daily News,

Just one thing wrong with tabloid stories - the facts  Mar 4, 2006
The amount of creativity in base-level tabloid reporting would make a Year 3 English teacher proud - and there's only so long you can sit back and take it. ... - The Observer,

Tabloid collection includes writer’s best, ‘worst’  Feb 28, 2006
...made it all up. But that didn’t bother the Florida-based tabloid the Sun, which bought his work in the mid-1980s. Some of his ... - El Paso Times,

The Tabloid Challenge  Feb 27, 2006
IAJ invites media workers, editors and journalists for an open panel discussion on tabloid journalism. ... Is there such a thing as ethical tabloid journalism? ... - Bizcommunity.com,

Tuesday's Tabloid Tales  Feb 28, 2006
Newcastle United striker Michael Owen does not think he will be fit enough to play in the FA Cup quarter-final against Chelsea next month. ... - MegaStar.co.uk,

Tabloid approach  Mar 2, 2006
...finding doesn't derail efforts to make Chapel Hill roads safer." The headline was sensational, more like what one would find in a tabloid rather than in your ... - News & Observer,

Daily Tabloid  Feb 28, 2006
Reading Daily Pundit is sort of like reading The National Enquirer - addictive if only for the unbelievably, shockingly sloppy reasoning behind gross political ... - Blogcritics.org,

Lay on some of that tabloid religion  Feb 24, 2006
I walked into the boss's office with a copy of the paper, slapped the page with the back of my hand and said, "Now this is religion fit for a tabloid.". ... - Winnipeg Sun,

Saudi tabloid shut down for cartoons  Feb 21, 2006
RIYADH, Saudi Arabia -- An editor at a Saudi tabloid newspaper that was closed down for republishing cartoons of the Prophet Muhammad defended the paper's ... - Seattle Post Intelligencer

Tabloid goes feral over stadium  Feb 23, 2006
By Joel Gibson and Tim Dick. Rebuilding Wembley Stadium has turned into a nightmare of delays, scandals and bad Aussie jokes for ... - Sydney Morning Herald,

Kaumudi to launch Kochi edition of tabloid  Feb 21, 2006
Kochi, Feb 21: The Malayalam newspaper Kerala Kaumudi will launch the Kochi edition of its mid-day tabloid 'Kerala Kaumudi Flash' on February 28. ... - Chennai Online,

Tabloid Tuesday: Jessica Simpson Has Loud Sex With Someone, More  Feb 21, 2006
...according to a hotel insider, security paid the couple a visit after a guest complained of loud, amorous noises coming from the room.� (TABLOID TUESDAY is ... - National Ledger,

Saudi Tabloid Shut Down for Cartoons  Feb 21, 2006
RIYADH, Saudi Arabia - An editor at a Saudi tabloid newspaper that was closed down for republishing cartoons of the Prophet Muhammad defended the paper‘s ... - Pierceland Herald,

"Tampa Tribune' Sues "St. Petersburg Times" Over New Tabloid's ...  Feb 20, 2006
Petersburg Times, over the name of a weekly tabloid that has published since 2004, and will be launched as a daily on March 6, The Times reported. ... - Editor & Publisher

Saudi tabloid closed for printing cartoons  Feb 21, 2006
The tabloid Shams (Sun) aimed at a youth audience in the Kingdom had printed the cartoons three weeks ago alongside an interview with Saudi cleric Salman Al ... - Judeoscope.ca,

Saudi tabloid closed for printing Prophet cartoons  Feb 21, 2006
RIYADH -- A Saudi tabloid was shut down on Monday after it printed cartoons of Prophet Mohammed as part of a campaign for more action against Denmark, where ... - Middle East Times,

Daily Exploits Of Angelina Jolie, Brad Pitt Drive Tabloid Sales  Feb 20, 2006
...by Jack Ryan. When the world's most important couple (Brad Pitt & Jennifer Aniston) broke up, part of us did too. Brad and Jen were ... - Post Chronicle

Tom Cruise May Sue Tabloid Over Break-Up Story  Feb 20, 2006
Tom Cruise is considering suing Life & Style for claiming the actor had ended his high-profile relationship with Katie Holmes, according to his lawyer Bert ... - Starpulse.com,

Tuesday's Tabloid Tales  Feb 21, 2006
Arsene Wenger has admitted that Arsenal's hopes of overcoming Real Madrid in the last 16 of the Champions League rest largely on the shoulders of captain ... - MegaStar.co.uk,

TABLOID TALES  Feb 20, 2006
Mirror: Juventus are ready to test the financial strength of Manchester United by reviving their interest in Cristiano Ronaldo. ... - the Blues Independent Everton Mad,

Monday's Tabloid Tales  Feb 20, 2006
Birmingham City boss Steve Bruce was relieved he made his peace with Nicky Butt last week as the midfielder played a key role in Sunday's 1-0 FA Cup victory at ... - MegaStar.co.uk,

Monday's Tabloid Tales  Feb 27, 2006
England striker Wayne Rooney was relieved to finally claim the first winner's medal of his senior football career after helping Manchester United secure the ... - MegaStar.co.uk,

Watch Out, Broadsheet: Tabloid Power is Gonna Get Your Mama  Feb 19, 2006
...to the 50-inch web; from broadsheet to what in Europe they call "compact" sizes: from the "super tab," known as the Berliner, down to the traditional tabloid. ... - Poynter.org,

Tabloid format is hardly the big cure  Feb 24, 2006
That’s been the notion in the newspaper industry over the last few years as one paper after another has gone tabloid in a bid to arrest circulation declines ... - Media Life Magazine

Volksblad goes Tabloid!  Feb 21, 2006
...message came through it all: The Volksblad's Saturday edition was being read by a younger audience than the Monday to Friday, and they were wanting tabloid! ... - Bizcommunity.com,

Tabloid Catches Tony Danza's Daughter Smoking Pot  Feb 23, 2006
The actor-turned-chat-show-host was horrified when he learned of tabloid plans to print pictures of his daughter Katie looking high in the back of a car and ... - Starpulse.com,

Union, tabloid media take aim at trucking  Feb 21, 2006
The TWU has also leaked driver statements to Sydney's Daily Telegraph tabloid, detailing their "impossibly punishing work schedules, which are fuelled by fear ... - Australasian Transport News (subscription),

The Tabloid Challenge  Feb 22, 2006
IIJ). South African journalists will get together with German colleagues to talk about issues related to tabloid journalism. This ... - International Journalist's Network

Saudi tabloid closed  Feb 20, 2006
RIYADH: A Saudi tabloid was shut down yesterday after it printed cartoons of Prophet Mohammed as part of a campaign for more action against Denmark, where the ... - Gulf Daily News,

Writer knows true story behind tabloid headlines  Feb 25, 2006
...he made up everything. That didn't bother the Florida-based tabloid the Sun, which bought his work in the mid-1980s. Some of his ... - Washington Times,

Ex-Saratoga publisher to launch new tabloid  Feb 23, 2006
SARATOGA SPRINGS -- A former publisher of The Saratogian plans to launch a new tabloid this spring, covering the city and surrounding areas. ... - Albany Times Union,

Trash talk: Tabloid roundup  Feb 28, 2006
...• "Break-in stuns Scotland Yard ... Spies steal [Princess] Di murder evidence ... Top British cop's computer missing!" (National Examiner). • "Exclusive ... ... - Dallas Morning News (subscription),

Dosage Forms Tablets, SR tablets
Drug_Category Adrenergic Agents; Dopamine Agents; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:N06BA04
Absorption readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. bioavailability is low (approx. 30%)
Interactions -->Interactions for Methylphenidate:

Ritalin may decrease the hypotensive effect of guanethidine. Use cautiously with pressor agents.

Human pharmacologic studies have shown that Ritalin may inhibit the metabolism of coumarin anticoagulants, anticonvulsants (phenobarbital, diphenylhydantoin, primidone), phenylbutazone, and tricyclic drugs (imipramine, clomipramine, desipramine). Downward dosage adjustments of these drugs may be required when given concomitantly with Ritalin.

Serious adverse events have been reported in concomitant use with clonidine, although no causality for the combination has been established. The safety of using methylphenidate in combination with clonidine or other centrally acting alpha-2 agonists has not been systemically evaluated.

 

Toxicity vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name methyl2-phenyl-2-(2-piperidyl)ethanoate
Chemical Formula C14H19NO2
Molecular Weight 233.306 g/mol
Smiles String COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Melting Point 224-226°C
Water Solubility 1255mg/L
State white, odorless, fine crystalline powder
LogP/Hphobicity 3.192
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 2.4 hours in children and 2.1 hours in adults
Protein Binding [%] low approx 15 %
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Methylphenidate.html
http://www.rxlist.com/cgi/generic/methphen.htm
Drug Type Approved Drug
Accession No APRD00657
CAS Registry Number 113-45-1
KEGG Compound ID C07196
PubChem ID SID:288739
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2249332

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