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Methylphenidate
drug data and news
Methylphenidate drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Methylphenidate | ||
| Brand Names/Synonyms | 4311/B Ciba; C 4311; CHEMBANK1663; Calocain; Centedein; Centedrin; Centedrine; Centredin; Concerta; Dea No. 1724; Focalin; Focalin Xr; HSDB 3126; METHYLPHEN; Meridil; Metadate; Metadate Cd; Metadate Er; Methyl Phenidyl Acetate; Methylin; Methylin Er; Methylofenidan; Methylphenidan; Methylphenidate; Methylphenidate Hcl; Methylphenidate Hydrochloride; Methylphenidatum [Inn-Latin]; Methylphenidylacetate Hydrochloride; Methypatch; Metilfenidat Hydrochloride; Metilfenidato [Inn-Spanish]; Metilfenidato [Italian]; Phenidylate; Plimasine; Pms-Methylphenidate; Riphenidate; Ritalin; Ritalin Hydrochloride; Ritalin La; Ritalin Sr; Ritalin-Sr; Ritaline; Ritcher Works | ||
| Indication | Children with attention deficit disorders | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Methylphenidate, a central nervous system stimulant chemically similar to the amphetamines, is used to treat narcolepsy, attention-deficit hyperactivity disorder (ADHD) in children, post-stroke depression or other depressive disorders. | ||
| Mechanism Of Action | Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result. | ||
| Methylphenidate News (When available) |
Gozo tabloid falls off the edge 07 Mar 2006 Commentary by Mark Creech 07 Mar 2006 TABLOID TALK Mar 5, 2006 Tabloid Shocker! Mar 3, 2006 Tabloid off streets Mar 4, 2006 Just one thing wrong with tabloid stories - the facts Mar 4, 2006 Tabloid collection includes writer’s best, ‘worst’ Feb 28, 2006 The Tabloid Challenge Feb 27, 2006 Tuesday's Tabloid Tales Feb 28, 2006 Tabloid approach Mar 2, 2006 Daily Tabloid Feb 28, 2006 Lay on some of that tabloid religion Feb 24, 2006 Saudi tabloid shut down for cartoons Feb 21, 2006 Tabloid goes feral over stadium Feb 23, 2006 Kaumudi to launch Kochi edition of tabloid Feb 21, 2006 Tabloid Tuesday: Jessica Simpson Has Loud Sex With Someone, More Feb 21, 2006 Saudi Tabloid Shut Down for Cartoons Feb 21, 2006 "Tampa Tribune' Sues "St. Petersburg Times" Over New Tabloid's ... Feb 20, 2006 Saudi tabloid closed for printing cartoons Feb 21, 2006 Saudi tabloid closed for printing Prophet cartoons Feb 21, 2006 Daily Exploits Of Angelina Jolie, Brad Pitt Drive Tabloid Sales Feb 20, 2006 Tom Cruise May Sue Tabloid Over Break-Up Story Feb 20, 2006 Tuesday's Tabloid Tales Feb 21, 2006 TABLOID TALES Feb 20, 2006 Monday's Tabloid Tales Feb 20, 2006 Monday's Tabloid Tales Feb 27, 2006 Watch Out, Broadsheet: Tabloid Power is Gonna Get Your Mama Feb 19, 2006 Tabloid format is hardly the big cure Feb 24, 2006 Volksblad goes Tabloid! Feb 21, 2006 Tabloid Catches Tony Danza's Daughter Smoking Pot Feb 23, 2006 Union, tabloid media take aim at trucking Feb 21, 2006 The Tabloid Challenge Feb 22, 2006 Saudi tabloid closed Feb 20, 2006 Writer knows true story behind tabloid headlines Feb 25, 2006 Ex-Saratoga publisher to launch new tabloid Feb 23, 2006 Trash talk: Tabloid roundup Feb 28, 2006 | ||
| Dosage Forms | Tablets, SR tablets | ||
| Drug_Category | Adrenergic Agents; Dopamine Agents; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:N06BA04 | ||
| Absorption | readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. bioavailability is low (approx. 30%) | ||
| Interactions |
-->Interactions for Methylphenidate: Ritalin may decrease the hypotensive effect of guanethidine. Use cautiously with pressor agents. Human pharmacologic studies have shown that Ritalin may inhibit the metabolism of coumarin anticoagulants, anticonvulsants (phenobarbital, diphenylhydantoin, primidone), phenylbutazone, and tricyclic drugs (imipramine, clomipramine, desipramine). Downward dosage adjustments of these drugs may be required when given concomitantly with Ritalin. Serious adverse events have been reported in concomitant use with clonidine, although no causality for the combination has been established. The safety of using methylphenidate in combination with clonidine or other centrally acting alpha-2 agonists has not been systemically evaluated. | ||
| Toxicity | vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | methyl2-phenyl-2-(2-piperidyl)ethanoate | ||
| Chemical Formula | C14H19NO2 | ||
| Molecular Weight | 233.306 g/mol | ||
| Smiles String | COC(=O)C(C1CCCCN1)C2=CC=CC=C2 | ||
| Melting Point | 224-226°C | ||
| Water Solubility | 1255mg/L | ||
| State | white, odorless, fine crystalline powder | ||
| LogP/Hphobicity | 3.192 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 2.4 hours in children and 2.1 hours in adults | ||
| Protein Binding [%] | low approx 15 % | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Methylphenidate.html http://www.rxlist.com/cgi/generic/methphen.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00657 | ||
| CAS Registry Number | 113-45-1 | ||
| KEGG Compound ID | C07196 | ||
| PubChem ID | SID:288739 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2249332 |
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